Modern Trends in Human Leukemia VI

In June 1984 a total of 169 physicians, scientists and students assembled in the now familiar and much-loved lair in the Wilsede Luneberg Heath near Hamburg, Germany, for the sixth biennial conference on Modern Trends in Human Leukaemia. This meeting, conducted by Prof. Rolf Neth in his own inimitable style, has established itself as one ofthe major events in the all too crowded programme of international conferences on leukaemia, cancer and related topics. Some may ponder why, with its "rustic" setting - flies, equine deposits, and lack of easy exit -, Wilsede has such an irresistible and persistent lure for so many of the world's top practitioners ofleukaemia research? The an­ swer is, I suspect, a cocktail of Rolfs extraordinary charm, the pleasure of meeting friends and colleagues in a uniquely informal and relaxed atmo­ sphere and the special style of the proceedings themselves, which focus on the evaluation of ideas and hypotheses rather than the cataloguing of data.

Frederick Stohlman Jr.: Memorial Lecture.- for N. A. Mitchison.- Repertoire Purging by Medium Concentration Self-Macromolecules is the Major Factor Determining Helper and Suppressor Repertoire Differences. (With 2 Figures).- for P. H. Duesberg.- Are Activated Proto-onc Genes Cancer Genes? (With 4 Figures).- New Strategies in Leukemia Diagnostic and Therapy.- Allogeneic Marrow Transplantation from HLA-Identical Siblings in the Acute Leukemias: Baltimore Experience.- Monoclonal Antibodies and Immunotoxins in Bone Marrow Transplantation: Purging Marrow of ALL or GVHD Cells with Preservation of Stem Cells.- Bone Marrow Transplantation for Acute Leukemia (With 1 Figure).- T Cell Depletion of Donor Marrow for Prevention of Acute Graft-Versus-Host Disease.- Long-Term Survivors of Adult Acute Nonlymphocytic Leukemia: Fact or Fiction? (With 2 Figures).- Risk Groups in a Multicenter Pilot Study for Treatment of Acute Lymphoblastic and Acute Undifferentiated Leukemia in Adults.- New Approaches to the Treatment of Chronic Myelogenous Leukemia.- The Feasibility of Opal/High Dose Ara-C Treatment for Adult Acute Lymphoblastic Leukaemia. (With 1 Figure).- Treatment of Leukemia with Low Dose Ara-C: A Study of 159 Cases.- Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndrome by Low Dose Cytosine Arabinoside.- The Results of High Risk Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphoma Total Therapy. (With 5 Figures).- Adult Acute Lymphoblastic Leukaemia at University Hospital, Malaysia.- The Epipodophyllotoxin VP16-213 in Combination Chemotherapy for Adults with Acute Nonlymphoblastic Leukaemia.- Treatment of Acute Lymphoblastic Leukemia in Childhood: A Report for the ALL 77-02 Group. (With 4 Figures).- Recent Results from Total Therapy Study X for Standard and High Risk Acute Lymphoblastic Leukemia in Children: Recognition of New Clinical and Biologic Risk Features.- Improved Treatment Results in Childhood Acute Myelogenous Leukemia: An Update of the German Cooperative Study AML-BFM-78.- Clinical Experiences with a Modified BFM Protocol in Childhood Acute Lymphoblastic Leukemia. (With 8 Figures).- Mechanisms of Drug Resistance in Human Leukemia.- Summary Overview of Clinical Session.- Red Cell Transfusions for Polytransfused Patients.- Gram-Negative Bacteraemia: New Therapeutic Possibilities with Anti-Endotoxin Antibodies.- Empirie Antimicrobial Therapy in Cancer Patients.- Prophylaxis of Infection in Granulocytopenic Patients.- Are Granulocyte Transfusions Helpful in Treating and Preventing Infections?.- Single Donor Platelet Transfusion.- Advances in Parenteral Nutrition Support of Children with Neoplastic Diseases.- Antiemetics in Cancer Chemotherapy.- Chromosome Abnormalities in Malignant Lymphoma: Biologie and Clinical Correlations. (With 2 Figures).- Oncogenetic Aspects of Chronic Myelocytic Leukemia. (With 4 Figures).- Association Between the Philadelphia Chromosome and a Unique abl Transcript. (With 3 Figures).- Somatic N-ras Oncogene Activation in a Patient with Acute Myeloblastic Leukemia. (With 2 Figures).- Behavior of Human Leukemic Progenitor Populations in Long-Term Marrow Culture.- Stromal Progenitor Cells in Bone Marrow of Patients with Aplastic Anemia. (With 5 Figures).- Dyserythropoiesis in Acute Lymphoblastic Leukemia of Childhood. (With 2 Figures).- Ultrastructural Analysis of Normal and Leukaemic Cells by the Immunogold Method and Monoclonal Antibodies. (With 6 Figures).- Immunocytochemical Labelling of Haematological Samples Using Monoclonal Antibodies. (With 1 Figure).- Myelolactoferrin Index (MLF) and Myelopoiesis During Bacterial Infections and Malignant Diseases. (With 5 Figures).- ?-Hexosaminidase Isoenzyme I: An Early Marker of Hematopoietic Malignancy. (With 1 Figure).- Analysis of Leukemic Cells with Monoclonal Antibodies in Acute Myelomonocytic Leukemia Suggests Abnormality at an Early Differentiation Stage in Certain Cases.- Nonspecific Cross-Reacting Antigen as a Marker of Myelocytic Leukemias in Individual Stages of Myelocytic Cell Differentiation. (With 2 Figures).- Plasminogen Activator as a Prognostic Factor in Hematological Malignancies.- Immune Status of Leukemia Patients. (With 3 Figures).- Differential Expression of a Glycoprotein (p15ERT) of Retroviral Origin in Patients Suffering from Various Hematological Disorders.- Discrimination of Leukemias, Lymphomas, and Non-Neoplastic Controls by Retroviral Serum Markers. (With 3 Figures).- Mechanism of Malignant Transformation Cellular Human Oncogens, Chromosomes and Viruses, Implication for Leukemia and Lymphoma.- Modulation of Gene Expression Through DNA-Binding Proteins: Is There a Regulatory Code? (With 6 Figures).- Cellular Oncogenes as the Ancestors of Endocrine and Paracrine Growth Factors and Their Evolutionary Relic Status in Vertebrates.- The Genes That Carcinogens Act Upon. (With 21 Figures).- Chromosome Alterations in Oncogenesis. (With 2 Figures).- Chromatin Structure of the Human c-myc Oncogene: Definition of Regulatory Regions and Changes in Burkitt’s Lymphomas. (With 3 Figures).- Identification of the Human Cellular myc Gene Product by Antibody Against the Bacterially Expressed Protein. (With 3 Figures).- Oncogenes of Avian Acute Leukemia Viruses are Subsets of Normal Cellular Genes. (With 1 Figure).- Structure and Function of ras and Blym Oncogenes.- TLym 1, a Stage-Specific Transforming Gene Which Shares Homology to MHCI Genes and Encodes a Secreted Protein.- The mil/raf and myc Oncogenes: Molecular Cloning and In Vitro Mutagenesis. (With 3 Figures).- Characterization of the Number of Carbohydrate Chains on the Avian Erythroblastosis Virus erb B Gene Product and Their Role in Transformation. (With 3 Figures).- Characterization of Hematopoietic Cells Transformed In Vitro by AEV-H, a v-erb B-Containing Avian Erythroblastosis Virus. (With 5 Figures).- Different Cellular Substrates of Abelson Leukemia Virus Transforming Protein Kinase in Murine Fibroblasts and Lymphocytes. (With 2 Figures).- Regulin, a Cytoskeleton-Associated Protein Affecting Phosphorylation-Dephosphorylation. (With 4 Figures).- Viruses as Tumor Initiators and Tumor Promoters.- Endemic and Sporadic Cases of Epstein-Barr Virus-Positive Burkitt’s Lymphoma: Immunological Characterization of Derived Cell Lines.- Herpesvirus HVMA: A New Representative in the Group of the EBV-like B-Lymphotropic Herpesviruses of Primates. (With 1 Figure).- Tumors Induced in Hairless Mice by DNA from Human Malignant Cells. (With 1 Figure).- The Human T-Cell Leukemia Virus Family, Adult T Cell Leukemia, and AIDS. (With 3 Figures).- Molecular Studies of Human T Cell Leukemia/Lymphotropic Retroviruses. (With 1 Figure).- The Molecular Biology of Human T Cell Leukemia Virus and its Roles in Leukemogenesis of Adult T Cell Leukemia. (With 3 Figures).- HTLV-I Antibodies Associated with Cutaneous T Cell Lymphoma in Denmark.- Presence of Antibodies to the Human T-Cell Leukemia Virus HTLV I in German Patients with Symptoms of AIDS. (With 1 Figure).- Roles of HTLV-I p19 and Natural Antibody to HTLV-I in Host Immune Responses.- Antibodies to Human T-Cell Leukemia Virus-Membrane Antigens in Macaques with Malignant Lymphoma.- Cellbiology.- Normal Regulators of Growth and Differentiation and the Reversal of Malignancy in Leukemia. (With 2 Figures).- Self-Renewal of Haemopoietic Stem Cells: The Roles of the Environment, of Growth Factors and of the src Oncogene. (With 2 Figures).- Coordinated Expression of c-myc Gene and a Multigenic Set May Modulate the Malignant Phenotype in Human Haemopoietic Cell Lines. (With 1 Figure).- Proliferation In Vivo and In Vitro of Haemopoietic Progenitor Cells Induced by AF-1, a New ras-Containing Retrovirus.- Cloning and Expression of the Gene for Murine Granulocyte-Macrophage Colony-Stimulating Factor. (With 4 Figures).- Partial Characterization of Murine Haematopoietic Cell Growth Factor mRNA. (With 3 Figures).- Molecular Cloning of cDNA for the Human Interleukin-2 Receptor. (With 5 Figures).- Purification of Normal Human T-Cell Growth Factor to Molecular Homogeneity.- Purification to Apparent Homogeneity and Biochemical Characterization of Human Pluripotent Hematopoietic Colony-Stimulating Factor. (With 1 Figure).- Differentiation in Myelodysplastic, Myeloid Leukaemic and Normal Haemopoietic Cells: A New Approach Exploiting the Synergistic Interaction Between Differentiation Inducers and DNA Synthesis Inhibitors. (With 4 Figures).- Vitamin D: Myeloid Differentiation and Proliferation. (With 4 Figures).- Biological Activities of a Human Pluripotent Hemopoietic Colony-Stimulating Factor.- A T Lymphocyte-Derived Differentiation-Inducing Factor for Myeloid Leukemia Cells: Purification and Characterization.- A Model Scheme of Hematopoietic Cell Differentiation Based on Multiple Marker Analysis of Leukemia-Lymphomas: T Cell Lineage. (With 2 Figures).- Changes in Isoenzyme Patterns Expressed by the Erythroleukemia Cell Lines K-562 and HEL After Induction of Differentiation. (With 1 Figure).- B Cell Lineage: Part of the Differentiation Program of Human Pluripotent Stem Cells.- Differentiation Capacity of Null-AL (L) Cells in Culture.- Evidence of Sternberg-Reed Cells Being Derived from Activated Lymphocytes. (With 1 Figure).- Production and Characterization of Monoclonal Antibodies Against the Human Leukemic Cell Line K562.- Immunological Aspects in Malignancy.- Lymphocyte and Lymphoma Receptors Utilized in Differentiation, in Homing, and in Lymphomagenesis.- Quantitative Expression and Function of Differentiation Antigens on Normal and Malignant Lymphoid Cells. (With 2 Figures).- Development of B Cell Subpopulations in Humans and its Relevance to Malignancy. (With 3 Figures).- Genetic Determination of the Cytolytic T Lymphocyte Receptor Repertoire. (With 5 Figures).- Internal Activity of the Immune System and its Physiologic Significance.- Antigen Presentation by Liposomes. (With 3 Figures).- Thymic Dendritic Cells Present Blood-Borne Antigens to Medullary Thymocytes In Vivo: A Possible Role in the Generation of the T-Cell Repertoire. (With 2 Figures).- Natural Defence and Chemical Carcinogenesis.- Genes and Antigens Controlling Tumor Metastases. (With 4 Figures).- Killer Cells in Leukemia. (With 1 Figure).- Influence of Colchicine and Cytochalasin B on Pinocytosis, Phagocytosis, and Antibody-Dependent Cell-Mediated Cytotoxicity.- In Vivo Studies with Covalent Conjugates of Cobra Venom Factor and Monoclonal Antibodies to Human Tumors. (With 3 Figures).