Mouse Models of Disease

ISBN 10: 0123744547 / ISBN 13: 9780123744548

Editore: Academic Press, 2008

This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide. Codice articolo ABBB-33461

Riassunto:

Like humans, mice naturally develop diseases that affect their immune, endocrine, nervous, cardiovascular, skeletal, and other physiological systems. As such mouse has become the premier mammalian model system for studying such diseases as cancer, atherosclerosis, hypertension, diabetes, osteoporosis, and glaucoma; moreover, certain diseases that occur in humans but not normally in mouse—CF, ALS, Huntingdon’s disease, for example—can be induced by manipulating the mouse genome and environment. This volume reviews current research findings and thought on mouse models for such human diseases as diabetes, cancer, Alzheimer’s, coronary disease, and hypertension, to name a few.

* Provides busy clinical and basic science researchers a one-stop overview and synthesis of the latest research findings and contemporary thought in the area.

* Allows researchers to compare and contrast disease models and also to learn about what models have been developed for large-scale distribution.

* Allows researchers to evaluate basic differences in mouse and human biology and propose alternate pathways and possible gene interactions of the disease.

Informazioni sull'autore: Robert S. Krauss is Mount Sinai Chair in Cell Biology; Professor of Cell, Developmental, and Regenerative Biology at the Icahn School of Medicine at Mount Sinai; and a member of The Black Family Stem Cell Institute and Mindich Child Health and Development Institute. His work focuses on the mechanisms of early embryonic development and adult tissue regeneration. His laboratory uses a wide combination of approaches to gain insight into how genes and the environment interact in the causation of common birth defects, and how adult stem cells are called into action to repair injury to tissues. His lab has constructed accurate animal models for holoprosencephaly, a common and often devastating birth defect, leading to identification of genetic and environmental risk factors. In other work, his lab has identified factors critical to regulation of adult stem cells and muscle regeneration.

Dati bibliografici

Titolo: Mouse Models of Disease
Casa editrice: Academic Press
Data di pubblicazione: 2008
Legatura: Rilegato
Condizione: New