Multiscale Approaches To Protein Modeling: Structure Prediction, Dynamics, Thermodynamics And Macromolecular Assemblies

ISBN 10: 1441968881 / ISBN 13: 9781441968883

Editore: Springer, 2010

Riguardo questo articolo

This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Codice articolo ABBB-158486

Dati bibliografici

• Titolo: Multiscale Approaches To Protein Modeling: Structure Prediction, Dynamics, Thermodynamics And Macromolecular Assemblies
• Editore: Springer
• Data di pubblicazione: 2010
• Lingua: Inglese
• ISBN 10: 1441968881
• ISBN 13: 9781441968883
• Rilegatura: Rilegato
• Condizione: New

Descrizione articolo

Riassunto

The book gives a comprehensive review of the most advanced multiscale methods for protein structure prediction, computational studies of protein dynamics, folding mechanisms and macromolecular interactions. It approaches span a wide range of the levels of coarse-grained representations, various sampling techniques and variety of applications to biomedical and biophysical problems. This book is intended to be used as a reference book for those who are just beginning their adventure with biomacromolecular modeling but also as a valuable source of detailed information for those who are already experts in the field of biomacromolecular modeling and in related areas of computational biology or biophysics.

Dalla quarta di copertina

Multiscale Approaches to Protein Modeling is a comprehensive review of the most advanced multiscale methods for protein structure prediction, computational studies of protein dynamics, folding mechanisms and macromolecular interactions. The approaches span a wide range of the levels of coarse-grained representations, various sampling techniques and variety of applications to biomedical and biophysical problems. Thanks to enormous progress in sequencing of genomic data, we presently know millions of protein sequences. At the same time, the number of experimentally solved protein structures is much smaller, ca. 60,000. This is because of the large cost of structure determination. Thus, theoretical, in silico, prediction of protein structures and dynamics is essential for understanding the molecular basis of drug action, metabolic and signaling pathways in living cells, designing new technologies in the life science and material sciences. Unfortunately, a brute force approach remains impractical. Folding of a typical protein (in vivo or in vitro) takes milliseconds to minutes, while state-of-the-art all-atom molecular mechanics simulations of protein systems can cover only a time period range of nanosecond to microseconds. This is the reason for the enormous progress in development of various mutiscale modeling techniques, applied to protein structure prediction, modeling of protein dynamics and folding pathways, in silico protein engineering, model-aided interpretation of experimental data, modeling of macromolecular assemblies and theoretical studies of protein thermodynamics. Coarse-graining of the proteins conformational space is a common feature of all these approaches, although the details and the underlying physical models span a very broad spectrum.