Nadolol Oral Wafers- Formulation and Optimization by Design Expert

Lingua: inglese

Editore: LAP LAMBERT Academic Publishing Sep 2021, 2021

6204203401 / 9786204203409

Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, GermaniaBuchWeltWeit Ludwig Meier e.K.

Venditore con 5 stelle

Venditore AbeBooks dal 11 gennaio 2012

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EUR 39,90

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Spedito da Germania a U.S.A.

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Descrizione dell’articolo da parte del venditore

This item is printed on demand - it takes 3-4 days longer - Neuware -Nadolol is a BCS Class III drug having low permeability and high solubility. It has low oral bioavailability. Formulation of Nadolol into wafers will help in improving the delivery of the drug. The design of the formulation started with the factorial design to optimize the independent variables like the amount of PEG, SLS and SSA. Formulation batches of wafers were prepared in accordance with Box BehnKen Design and evaluation tests were performed. It was observed that the independent parameters concentration of PEG, SLS and SSA show impact on disintegration time, folding endurance and thickness of the wafers. The data obtained in the factorial experiments was used for plotting response-surface and contour plots and data was analyzed by ANOVA. Optimized formulae were given by the software. The optimized formulations were prepared and evaluated. The formulation having the lowest % relative error of the predicted values given by the software and the experimental values was considered the best. OF1 was found to show better results. The optimized formulation of nadolol loaded wafers was then subjected to in vitro drug release studies. 84 pp. Englisch.…

Codice articolo 9786204203409

Titolo
Nadolol Oral Wafers- Formulation and Optimization by Design Expert
Autore
Harani Avasarala
Editore
LAP LAMBERT Academic Publishing Sep 2021
Anno di pubblicazione
2021
Condizione
Neu
Rilegatura
Taschenbuch
Lingua
inglese
ISBN 10
6204203401
ISBN 13
9786204203409
Peso dell'articolo
143 grammi
Dimensioni
220x150x6 mm

BuchWeltWeit Ludwig Meier e.K.

Bergisch Gladbach, Germania

Venditore con 5 stelle

Venditore AbeBooks dal 11 gennaio 2012

Tariffe di spedizione da Germania a U.S.A.

ArticoloDa 5 a 15 giorni lavorativiDa 5 a 15 giorni lavorativi
Primo articoloEUR 23,00EUR 23,00
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BuchWeltWeit Ludwig Meier e.K.

Germania