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Titolo: Neurobehavioral Genetics: Methods and ...

Casa editrice: CRC Press

Data di pubblicazione: 1999

Legatura: Hardcover

Condizione: Tr�s bon

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Riassunto:

Neurobehavioral Genetics: Methods and Applications covers classic and contemporary approaches to the study of the brain and behavior, including basic and clinical research. This book is designed as a reference for investigators wishing to incorporate genetic methods into neurobehavioral research. A broad spectrum of methods are integrated, unlike any other publication currently in print.
Neurobehavioral Genetics: Methods and Applications presents different models, from invertebrates to genetically defined mammals.
Introductory chapters demonstrate the scope and power of genetic methods that can be applied to neurobehavioral research from statistical methods and linkage analysis to contemporary molecular genetic approaches to search for candidate genes.
The second half of the book covers the applications of quantitative and molecular genetics in basic and clinical research. Topics covered include animal behavior and neurobiology and human clinical problems including neurodegenerative diseases and psychiatric disorders.

Contenuti:

A Retrospect on Neurobehavioral Genetics
PART 1: BASIC QUANTITATIVE AND STATISTICAL METHODS
An Introduction to Quantitative Genetics
Planning Genetic Experiments: Power and Sample Size
Classical Linkage Analysis
PART 2: MOVING FROM MATHEMATICS TO GENES
Neurogenetics: Mendelian Genetics - Single-Gene Effects and Some of Their Complicating Factors
Quantitative Trait Loci (QTL) Mapping
From QTL Detection to Gene Identification-M. P. Moisan
Knockouts: Constitutive, Inducible, or Tissue Specific. The Example of 5-HT Receptors-R. Grailhe and R. Hen
PART 3: ANIMAL MODELS
Behavioral Phenotyping of Transgenic and Knockout Mice-J. N. Crawley
Animal Models in Neurobehavioral Genetics: Methods for Estimating Genetic Correlation - John C. Crabbe
PART 4: HUMAN METHODS
Human Family Studies-L. M. Karkowski
The Twin Method-M. Carlier and E. Spitz
PART 5: GENE-ENVIRONMENT INTERACTIONS AND MATERNAL EFFECTS
Detecting and Measuring Gene-Environment Interaction in Human Temperament (Aggressivity) and Personality Deviation (Conduct Disorder, Antisocial Personality)-K. Riggins-Caspers and
R. J. Cadoret
Maternal Effects in Behavior Genetic Analysis-
M. Carlier, P. Roubertoux, and D. Wahlsten
PART 6: METHODS AND APPLICATIONS IN NEUROGENETICS
Cerebellar Functions: A Behavioral Neurogenetic Perspective-L. Rondi-Reig, J. Caston, N. Delhaye-Bouchaud, and J. Mariani
Natural Genetic Variation of Hippoccampal Structures and Behavior-H. P. Lipp and D. P. Wolfer
Human Neurogenetics: Neurodegenerative Diseases-A. D. D�rr
PART 7: PSYCHIATRIC GENETICS
Schizophrenia: Study of a Genetically Complex Phenotype-M. F. Pogue-Geile and I. I. Gottesman
Genetics of Autism and Its Place in an Integrated Clinicobiological Approach-S. Tordjman
Genetic Basis of Mental Retardation-L. Colleaux
PART 8: GENETICS OF AGGRESSION AND EMOTIONALITY
Aggression: Concepts and Methods Relevant to Genetic Analyses n Mice and Humans-S. Maxson
Genetics and Emotional Behaviors: Experimental Studies-P. Morm�de and A. Ramos

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