Neurobiology of Glycoconjugates

R. K. Margolis

ISBN 10: 1475759576 / ISBN 13: 9781475759570

Editore: Springer, Springer New York, 2013

Riguardo questo articolo

Druck auf Anfrage Neuware - Printed after ordering - Ten years ago the general area covered in this volume was comprehensively surveyed for the first time (Complex Carbohydrates of Nervous Tissue. Plenum Press, 1979). The revised title of the present volume reflects a number of important changes in content and emphasis, which have been made possible by the accelerating pace of research in this field. A third of the chapters did not appear in the predecessor volume, and over half of the remainder have new authors. Many advances relating to the functional aspects of nervous tissue glycoconjugates have resulted from the application of sensitive and specific immunocytochemical techniques to studies on their localiza tion and developmental changes. In the past ten years, the importance of various extracellular matrix macromolecules such as laminin, fibronectin, tenascin, and heparan sulfate proteoglycans has also become generally recognized, as has the role of specialized oligosaccharide structures in cell interactions and developmental processes. In certain cases, connecting links have been discovered between seemingly unrelated research areas, such as the finding that a number of nervous tissue glycoproteins with probable roles in cell interactions (e.g., Thy-I, NCAM, and the myelin-associated glycoprotein) all belong to the immunoglobulin superfamily. The next decade of research will undoubtedly prove to be particularly exciting.

Codice articolo 9781475759570

Dati bibliografici

• Titolo: Neurobiology of Glycoconjugates
• Editore: Springer, Springer New York
• Data di pubblicazione: 2013
• Lingua: Inglese
• ISBN 10: 1475759576
• ISBN 13: 9781475759570
• Rilegatura: Taschenbuch
• Condizione: Neu
• Dimensioni: 254 L x 178 A x 26 P (millimetri) 254 millimetri di larghezza per 178 millimetri di altezza per 26 millimetri di profondità
• Peso: 880 grammi

Descrizione articolo

Riassunto

Ten years ago the general area covered in this volume was comprehensively surveyed for the first time (Complex Carbohydrates of Nervous Tissue. Plenum Press, 1979). The revised title of the present volume reflects a number of important changes in content and emphasis, which have been made possible by the accelerating pace of research in this field. A third of the chapters did not appear in the predecessor volume, and over half of the remainder have new authors. Many advances relating to the functional aspects of nervous tissue glycoconjugates have resulted from the application of sensitive and specific immunocytochemical techniques to studies on their localiza­ tion and developmental changes. In the past ten years, the importance of various extracellular matrix macromolecules such as laminin, fibronectin, tenascin, and heparan sulfate proteoglycans has also become generally recognized, as has the role of specialized oligosaccharide structures in cell interactions and developmental processes. In certain cases, connecting links have been discovered between seemingly unrelated research areas, such as the finding that a number of nervous tissue glycoproteins with probable roles in cell interactions (e.g., Thy-I, NCAM, and the myelin-associated glycoprotein) all belong to the immunoglobulin superfamily. The next decade of research will undoubtedly prove to be particularly exciting.

Contenuti

1 Structure and Localization of Gangliosides.- 2 Biosynthesis, Metabolism, and Biological Effects of Gangliosides.- 3 Structure and Localization of Glycoproteins and Proteoglycans.- 4 Biosynthesis of Glycoproteins.- 5 Biosynthesis of Glycosaminoglycans and Proteoglycans.- 6 Lysosomal Degradation of Glycoproteins and Glycosaminoglycans.- 7 Glycoproteins of the Synapse.- 8 Glycoproteins of Myelin and Myelin-Forming Cells.- 9 Axonal Transport and Intracellular Sorting of Glycoconjugates.- 10 Synaptic Vesicle Glycoproteins and Proteoglycans.- 11 Carbohydrate Recognition, Cell Interactions, and Vertebrate Neural Development.- 12 Polysialic Acid as a Regulator of Cell Interactions.- 13 Extracellular Matrix Adhesive Glycoproteins and Their Receptors in the Nervous System.- 14 Hyaluronate and Hyaluronate-Binding Proteins of Brain.- 15 Inborn Errors of Complex Carbohydrate Catabolism.