Neuropathogenic Viruses and Immunity

Steven Specter

ISBN 10: 1468458884 / ISBN 13: 9781468458886

Editore: Springer US, 2012

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Druck auf Anfrage Neuware - Printed after ordering - There has been a tremendous increase in interest in the neuropathogenicity of viruses during the past decade as we have come to recognize that the human immunodeficiency virus, which causes the acquired immunodeficiency syndrome (AIDS), can infect glial cells and cause neurological disease. Yet this increase has not been limited to AIDS but has extended to viruses that infect either or both the central and peripheral nervous systems. The changes examined here include both neurological and psychological diseases or syndromes. Moreover, the chapters in this volume review the interaction of the host immune system with the viruses examined and how such interactions may increase or decrease the neuropatho genicity of the viruses. Questions regarding viral neuropathogenesis include: (I) What is the mode of transmission of virus to the nervous system (2) What types of cells are infected, and do they contain receptors for the virus (3) What is the extent of damage that results from viral infection (4) What are the immunologic mecha nisms by which damage is mediated or limited Many of these questions remain unanswered, but this volume delves into efforts to provide some answers.

Codice articolo 9781468458886

Dati bibliografici

• Titolo: Neuropathogenic Viruses and Immunity
• Editore: Springer US
• Data di pubblicazione: 2012
• Lingua: Inglese
• ISBN 10: 1468458884
• ISBN 13: 9781468458886
• Rilegatura: Taschenbuch
• Condizione: Neu
• Dimensioni: 229 L x 152 A x 21 P (millimetri) 229 millimetri di larghezza per 152 millimetri di altezza per 21 millimetri di profondità
• Peso: 544 grammi

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Riassunto

There has been a tremendous increase in interest in the neuropathogenicity of viruses during the past decade as we have come to recognize that the human immunodeficiency virus, which causes the acquired immunodeficiency syndrome (AIDS), can infect glial cells and cause neurological disease. Yet this increase has not been limited to AIDS but has extended to viruses that infect either or both the central and peripheral nervous systems. The changes examined here include both neurological and psychological diseases or syndromes. Moreover, the chapters in this volume review the interaction of the host immune system with the viruses examined and how such interactions may increase or decrease the neuropatho­ genicity of the viruses. Questions regarding viral neuropathogenesis include: (I) What is the mode of transmission of virus to the nervous system? (2) What types of cells are infected, and do they contain receptors for the virus? (3) What is the extent of damage that results from viral infection? (4) What are the immunologic mecha­ nisms by which damage is mediated or limited? Many of these questions remain unanswered, but this volume delves into efforts to provide some answers.

Contenuti

Viruses and Neuropsychiatric Disorders; S. Specter, et al. General Information: Immune Responses and the CNS; W.R. Tyor, R.T. Johnson. Virus Infection of Peripheral Nerves; M.C. Graves, H.V. Vinters. Animal Models: Visna, A Lentiviral Disease of Sheep; G. Perursson, et al. Picornavirus Animal Model; H.L. Lipton, C.D. Canto. Unconventional Infectious Agent: Scrapie; R.I. Carp. Human Infections of the CNS: Enteroviruses; J.L. Melnick. Paramyxoviruses; C. Orvell. Neurological Aspects of Human Immunodeficiency Virus Infection; H.E. Gendelman, S. Gendelman. Alphaviruses, Flaviviruses and Bunyaviruses; D.E. Griffin. Perspectives: Possible Viral Etiology of Multiple Sclerosis; H.E. Webb. Viruses and Schizophrenia; J.R. Stevens, L.M. Hallick. The Role of Viruses in Dementia; A.M. Deatly, et al. 4 additional articles. Index.