Neurophenotypes

Lingua: inglese

Editore: Springer, Springer Feb 2017, 2017

1461438454 / 9781461438458

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This item is printed on demand - Print on Demand Titel. Neuware -The interest in 'biomarkers' seen across a spectrum of biomedical disciplines reflects the rise of molecular biology and genetics. A host of 'omics' disciplines in addition to genomics, marked by multidimensional data and complex analyses, and enabled by bioinformatics, have pushed the trajectory of biomarker development even further. They have also made more tractable the complex mappings of genotypes to phenotypes - genome-to-phenome mapping - to which the concept of a biomarker is central.Genomic investigations of the brain are beginning to reveal spectacular associations between genes and neural systems. Neural and cognitive phenomics are considered a necessary complement to genomics of the brain. Other major omics developments such as connectomics, the comprehensive mapping of neurons and neural networks, are heralding brain maps of unprecedented detail. Such developments are defining a new era of brain science. And in this new research environment, neural systems and cognitive operations are pressed for new kinds of definitions - that facilitate brain-behavioral alignment in an omics operating environment.This volume explores the topic of markers framed around the constructs of cognitive and neural systems. 'Neurophenotype' is a term adopted to describe a neural or cognitive marker that can be scientifically described within an associative framework - and while the genome-to-phenome framework is the most recognized of these, epigenetics and non-gene-regulated neural dynamics also suggest other frameworks. In either case, the term neurophenotype defines operational constructs of brain-behavioral domains that serve the integration of these domains with neuroscientific and omics models of the brain. The topic is critically important to psychiatry and neuropsychology: Neurophenotypes offer a 'format' and a 'language' by which psychiatry and neuropsychology can be in step with the brain sciences. They also bring a new challenge to the clinical neurosciences in terms of construct validation and refinement.Topics covered in the volume include:Brain and cognition in the omics eraPhenomics, connectomics, and Research Domain CriteriaCircuit-based neurophenotypes, and complications posed by non-gene regulated factorsThe legacy of the endophenotype concept - its utility and limitationsVarious potential neurophenotypes of relevance to clinical neuroscience, including ResponseInhibition, Fear Conditioning and Extinction, Error Processing, Reward Dependence and Reward Deficiency, Face Perception, and Language PhenotypesDynamic (electrophysiological) and computational neurophenotypesThe challenge of a cultural shift for psychiatry and neuropsychologyThe volume may be especially relevant to researchers and clinical practitioners in psychiatry and neuropsychology and to cognitive neuroscientists interested in the intersection of neuroscience with genomics, phenomics and other omics disciplines.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 328 pp. Englisch.…

Codice articolo 9781461438458

Titolo
Neurophenotypes
Autore
Vinoth Jagaroo
Editore
Springer, Springer Feb 2017
Anno di pubblicazione
2017
Condizione
Neu
Rilegatura
Buch
Lingua
inglese
ISBN 10
1461438454
ISBN 13
9781461438458
Peso dell'articolo
658 grammi
Dimensioni
241x160x24 mm

buchversandmimpf2000

Emtmannsberg, BAYE, Germania

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Tariffe di spedizione da Germania a U.S.A.

ArticoloDa 60 a 60 giorni lavorativiDa 60 a 60 giorni lavorativi
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