The Oncogenomics Handbook (Hb)

ISBN 10: 1588294250 / ISBN 13: 9781588294258

Editore: Humana, 2005

Brand New Original US Edition. Customer service! Satisfaction Guaranteed. Codice articolo ASNNN-74800

Riassunto:

The Oncogenomics Handbook provides a comprehensive update of a variety of perspectives and the consequential approaches toward advancing cancer therapy. The handbook discusses genomic databases and presents examples of elegant approaches to discover oncology targets, expands the understanding of the tractable genome from the gene and transcript to the realm of proteomics that provide an understanding at the level of protein biochemistry, as well as providing an overview of clinical diagnostics, bioanalytics and biomarkers as well as the importance of these molecules to therapeutic outcome.

Dalla quarta di copertina: Bioinformatic integration of the findings from recent genomic and proteomic research has made possible the development of highly selective therapeutics that can target specific cellular pathways controlling cell proliferation, differentiation, metastasis, evasion of immune surveillance, angiogenesis, and apoptosis. In The Oncogenomics Handbook, a panel of internationally recognized researchers and clinicians provides an integrated overview of cancer drug discovery and development from the bench to the clinic, showing with broad strokes and representative examples the drug development process as a network of linked components leading from the discovered target to the ultimate therapeutic product. Following that path, the authors explain genomic databases and how to discover oncological targets from them, how then to advance from the gene and transcript to the level of protein biochemistry, how next to move from the chemical realm to that of the living cell and, ultimately, pursue animal modeling and clinical development. Emerging cancer therapeutics including rituximab, Herceptin®, Avastin™, ABGX-EGF, Velcade®, Iressa®, and Zevalin® are addressed. Additional chapters review clinical diagnostics, bioanalytics, and biomarkers and their importance to therapeutic outcome; detail antiangiogenic, supportive, immunomodulatory, and tumor-targeted approaches to cancer therapy; and provide a systems biology-bioinformatics overview of strategies and initiatives for the postgenomic era. Highlights include cancer genomics, transcriptomics, gene expression analysis, proteomic and enzymatic cancer profiling technologies, and cellular and animal approaches to cancer target validation.
Authoritative and state-of-the-art, The Oncogenomics Handbook offers cancer researchers and drug developers a comprehensive update on the contribution of the genomic revolution to cancer drug discovery and development.

Dati bibliografici

Titolo: The Oncogenomics Handbook (Hb)
Casa editrice: Humana
Data di pubblicazione: 2005
Legatura: Rilegato
Condizione: New