Optimization of Nanoparticles composed Pyridostigmine: Preparation, Evaluation & Optimization

Kumar, Niwash; Singh, Nitish Kumar

ISBN 10: 6205517426 / ISBN 13: 9786205517420

Editore: LAP LAMBERT Academic Publishing, 2022

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Dati bibliografici

• Titolo: Optimization of Nanoparticles composed Pyridostigmine: Preparation, Evaluation & Optimization
• Editore: LAP LAMBERT Academic Publishing
• Data di pubblicazione: 2022
• Lingua: Inglese
• ISBN 10: 6205517426
• ISBN 13: 9786205517420
• Rilegatura: Brossura
• Condizione: New

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Riassunto

The purpose of this book will to prepare Pyridostigmine nanoparticles for control release of Pyridostigmine to improve the oral bioavailability, enhance the solubility and dissolution rate by decreasing particle size of drug. Infrared spectroscopic studies confirmed that there was no interaction between drug and polymers. The controlled release Pyridostigmine nanoparticles were prepared by Solvent evaporation by using Ethyl cellulose, Chitosan & HPMC K100 at different ratios. The production yield of the formulated controlled release nanoparticles (F1 to F16) in the range of 76.11 % to 83.58 %. The drug content of the formulated controlled release nanoparticles (F1 to F16) in the range of 82.56 %to 98.20%. The Theoretical loading of the formulated controlled release nanoparticles (F1- F16) in the range of 24.43 % to 64.24%. The entrapment efficiency increased with increasing the concentration of polymers and the formulations containing chitosan nanoparticles F6 (1:2) showed better entrapment (90.94%) among all formulation.