Orotic Acid: Synthesis, Biochemical Aspects and Physiological Role (Paperback or Softback)

Cih�k, A.

ISBN 10: 9400980450 / ISBN 13: 9789400980457

Editore: Springer 10/5/2011, 2011

Riguardo questo articolo

Orotic Acid: Synthesis, Biochemical Aspects and Physiological Role 0.43.

Codice articolo BBS-9789400980457

Dati bibliografici

• Titolo: Orotic Acid: Synthesis, Biochemical Aspects and Physiological Role (Paperback or Softback)
• Editore: Springer 10/5/2011
• Data di pubblicazione: 2011
• Lingua: Inglese
• ISBN 10: 9400980450
• ISBN 13: 9789400980457
• Rilegatura: Paperback or Softback
• Condizione: New
• Tipo di libro: Book

Descrizione articolo

Riassunto

This volume reviews a series of different publications dealing with orotic acid. Orotic acid was isolated from cow's milk 75 years ago by Biscaro and Belloni in Italy. Fifty years later again Italian scientists described the growth-promoting activity of orotic acid in vitamin B -deficient animals. 12 Orotic acid is the precursor of pyrimidine nucleotides which are involved in many biochemical reactions: UTP and CTP, as substrates for RNA polymerase, and UDP sugars, as substrates for carbohydrate containing macromolecules, e.g. glycogen, glycoproteins and glycolipids. The biosynthesis of these pyrimidines is well regulated. Disturbance of the biosynthetic pathway or trapping of individual pyrimidine nucleotides may lead to severe metabolic and structural alterations of cells. Synthesis, biochemical aspects and physiological role are reviewed in nine chapters. In the last two decades increasing interest in orotic acid came from several studies showing protective or therapeutic or beneficial effects of this compound in different kinds of organ injuries: various forms of hepatic insufficiency, myocardial infarction, encephalopathy, memorization pro­ cesses, mentioned in Chapters 8 and 9. At the end of this overview a Bibliography in an alphabetical order with 673 references may give further insight in this topic.

Contenuti

1. New growth factor?.- 2. Pathway of pyrimidine synthesis de novo.- 3. Aggregation of enzymes of the orotate pathway.- 4. Efficiency and regulation of pyrimidine synthesis.- 5. Alterations in orotic acid excretion.- 6. Inhibitors of the orotate pathway.- 7. Induction of fatty liver in rats.- 8. Physiological effects.- 9. Orotic acid in human therapy.