An Overview of Genetic Factors and Environmental Triggers in the Pathogenesis of Tourette's Syndrome

Miao Zhimin Liu Shi-guo Dong Qian Yang Ping Wang Cong-yi

ISBN 10: 1616687487 / ISBN 13: 9781616687489

Editore: Nova Science Publishers, Incorporated, 2010

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pp. xii + 59 Acknowledgement. Codice articolo 181297521

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Titolo: An Overview of Genetic Factors and ...

Casa editrice: Nova Science Publishers, Incorporated

Data di pubblicazione: 2010

Legatura: Brossura

Condizione: Used

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Riassunto:

Tourette's syndrome (TS) is an inheritable, childhood-onset neuropsychiatric disorder characterised by the presence of motor and phonic tics. Despite decades of extensive studies, the exact disease aetiology remains poorly understood. It is believed that susceptibility to TS is determined by the interactions of multiple genetic loci with unknown environmental factors. As a result, a great deal of research has been focused on identifying TS susceptibility genes. Thus far, at least 12 susceptibility loci have been suggested by genome-wide screenings, but none of them has been replicated probably due to genetic heterogeneity. Candidate gene approach has also suggested evidence for several genes relevant to neuronal signalling such as dopamine receptor and serotonin receptor. This book discusses the current state of genetic studies in TS susceptibility.