Riassunto
Oxidative stress and aging Over the past several years there has been an extraordinarily rapid growth in our knowledge of free radical chemistry and its possible involvement in both normal essential biology and age related disease and dysfunction. Much of this growth in the traditionally separate sciences of chemistry and molecular gerontology occurred independently, with little interaction or communi cation between the scientists working in these two fields. In view of the growing maturity of the two fields and the potential importance of advancing our knowledge in the area of oxidative stress and aging, we perceived a critical need to organize an international conference the "First Inter national Conference on Oxidative Stress and Aging" in Hawaii in 1994 to bring together the world's leading scientists in the fields of reactive oxygen species and molecular gerontology. The objective of this conference was to provide a unique opportunity for scholars working in these two related and rapidly growing fields to participate in the exchange, integration, and synthesis of new concepts and ideas, to engage in constructive criticism and to initiate new collaborative research projects. The conference focused on the molecular and cellular aspects of aging as related to oxidative stress. It was one of the largest and most comprehensive international conferences held in molecular gerontology. At this conference a call was made for submission of papers to be used in the publication of a book covering the major contributions of the meeting.
Contenuti
Introductory papers.- Oxidative stress, antioxidants, aging and disease.- Longevity determinant genes, cellular dysdifferentiation and oxidative stress.- Oxidative stress and cellular senescence.- Oxidative stress and apoptosis.- Superoxide and hydrogen peroxide as cellularly generated life-signals in the balance between proliferation and cell death.- Cellular aging and oxidative stress.- Cellular nitrogen oxide production: Its role in endogeneous mutation and carcinogenesis.- Vascular smooth muscle cell proliferation is controlled by d-?-tocopherol at the level of protein kinase C and of the transcription factor AP-1.- Genetic stability and damage: DNA repair.- DNA damage and epigenetic mechanisms of aging.- Formation of 8-hydroxyguanine in DNA by aging and oxidative stress.- Age-dependent DNA modifications (I-compounds): Effects of carcinogenesis and oxidative stress.- Iron-induced carcinogenesis in experimental animals: A free radical mechanism of DNA damage and carcinogenesis.- DNA repair, oxidative stress and aging.- Genetics and lifespan.- Poly(ADP-ribose) polymerase: Correlation of enzyme activity with the life span of mammalian species and use of a dominant negative version to elucidate biological functions of poly(ADP-ribosyl)ation.- Antioxidant genes and other mechanisms involved in the extended longevity of Drosophila.- Proteins and lipid oxidation.- Novel approaches toward inhibition of the Maillard reaction in vivo: Search, isolation and characterization of prokaryotic enzymes which degrade glycated substrates.- Age-associated changes of oxidative modification and turnover of proteins.- Mitochondria.- Mitochondria, free radicals, neurodegeneration and aging.- Free radicals and muscle damage due to immobilization of old animals: Effect of growth hormone.- PCR analysis of mitochondrial DNA from normal and transgenic glutathione peroxidase mice.- Aging related diseases and cancer.- Free radicals in the pathogenesis of diabetes and its complications.- Oxidative stress and its relationship to carcinogen activation.- The chemoprevention of cancer by dietary carotenoids: Studies in mouse and human cells.- Accumulation of ubiquitinated proteins in aging mouse brains.- Protective action of Bio-normalizer against oxidative stress and brain disorders.- Islet redox state, calcium uptake and insulin secretion: Effects of old age and oxidative stress.- Free radical scavenger properties of EGB 761 on functional disorders induced by experimental diabetic retinopathy.- Aging related diseases: Neurodegeneration.- Oxidative stress in neurobiology: An important role for iron.- Parkinson’s disease, dopamine and free radicals.- Oxidative stress and brain damage as the pathogenesis of epilepsy.- Senile neurodegeneration: Pathogenic role of microglia-derived free radicals.- Nutrition.- Modulation of oxidative stress as a means of life-prolonging action of dietary restriction.- Dietary vitamin E in oxidative stress and aging.- Tea and its components as powerful antioxidants.- Protective role of dietary antioxidants in oxidative stress.- Nitric oxide.- Nitrone spin-traps release nitric oxide reaction with reactive oxygen species: Possible mechanism of biological activity.- Age-related changes in nitric oxide content and nitric oxide synthase activity in senescence-accelerated mouse (SAMP8) brain.
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