Riassunto:
A volume within the Subcellular Biochemistry series is an appropriate setting for the first multi-author book devoted to the new family of antioxidant and cell signalling proteins, the peroxiredoxins. Within the antioxidant and cell signalling fields, even the existence of the peroxiredoxins has yet to be appreciated by many; with this book we aim to rectify this situation. We have tried to select diverse chapter topics to cover relevant aspects of the subject and to persuade knowledgeable authors to contribute a manuscript. As almost inevitable, a few authors let us down by failing to respond, others could not submit a manuscript in time for personal reasons. These unfortunately were two of the pioneers, Earl Stadtman and Sue Goo Rhee, but we appreciate that they communicated a lot of details that helped us to reconstruct the early phase of peroxiredoxin enzymology. We have thus compiled a book that competently covers the peroxiredoxin field from its beginnings through to currently relevant topics. In the introductory Chapter 1 we provide a short historical survey of the subject, based upon the early structural and enzymic studies on peroxiredoxins, and then lead into some of our current personal interests, such as the likely continuing contribution of transmission electron microscopy (TEM) for the study of high molecular mass peroxiredoxin complexes and the association of peroxiredoxins with other proteins, and the targeting of drugs against microbial peroxiredoxins, as future therapeutic approaches.
Contenuti:
Contributing Authors Preface Chapter 1. Introduction: History of the Peroxiredoxins and Topical Perspectives Leopold Flohé and J. Robin Harris Chapter 2. Evolution of the Peroxiredoxins (Taxonomy/Homology/Characterization) Bernard Knoops, Eléonore Loumaye and Valérie Van der Eecken Chapter 3. Structural Survey of the Peroxiredoxins P. Andrew Karplus and Andrea Hall Chapter 4. The Catalytic Mechanism of Peroxiredoxins Leslie B. Poole Chapter 5. Kinetics of Peroxiredoxins and their Role in the Decomposition of Peroxynitrite Madia Trujillo, Gerardo Ferrer-Sueta, Leonor Thomson, Leopold Flohé and Rafael Radi Chapter 6. The Peroxiredoxin Repair Proteins Thomas J. Jönsson and W. Todd Lowther Chapter 7. Peroxiredoxins in Bacterial Antioxidant Defense James M. Dubbs and Skorn Mongkolsuk Chapter 8. The NADH oxidase-Prx system in Amphibacillus xylanus Youichi Niimura Chapter 9. Peroxiredoxin Systems in Mycobacteria Timo Jaeger Chapter 10. Peroxiredoxin systems of protozoal parasites Marcel Deponte, Stefan Rahlfs and Katja Becker Chapter 11. The Trypanaothione System Luise R. Krauth-Siegel, Marcelo A. Comini and Tanja Schlecker Chapter 12. Functions of Typical 2-Cys Peroxiredoxins in Yeast Brian A. Morgan and Elizabeth A. Veal Chapter 13. The Dual Function of Plant Peroxiredoxins in Antioxidant Defence and Redox Signaling Karl-Josef Dietz Chapter 14. Mitochondrial Peroxiredoxins: Structure and Function Zhenbo Cao, J. Gordon Lindsay and Neil W. Isaacs Chapter 15. Peroxiredoxins in the Lung with Emphasis on Peroxiredoxin VI Bruno Schremmer, Yefim Manevich, Sheldon I. Feinstein, and Aron B. Fisher. Chapter 16. Peroxiredoxins in Gametogenesis andEmbryo Development Isabelle Donnay and Bernard Knoops Chapter 17. Peroxiredoxins in the Central Nervous System Fumiyuki Hattori and Shinzo Oikawa Chapter 18. Stress-induced Peroxiredoxins Tetsuro Ishii and Toru Yanagawa Index
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