Perspectives in Inflammation : Future Trends and Developments

This report on Future Trends in Inflammation III is the record of what is now firmly established as a series of multidisciplinary meetings organized by the European Biological Research Association. The aim of these meetings is to provide a forum for free exchange of information between basic scien­ tists of many disciplines and clinicians to provide better understanding of problems of common interest. The next major meeting wi1l be held in 1980.* The European Biological Research Association promotes scientific and clinical collaboration among the member countries ofthe EEe. It encourages exchange of information between scientists and clinicians from centres all over the world. In addition to the major international meetings small work­ shops are organized on specific problems of common interest. Once again the Editors have attempted to capture the spirit of the meeting by publishing 'verbatim' the discussion. It can be seen that the discussions were exciting and formed an important part of the meeting. It is possible that inaccuracies have crept into the discussions; if so we apologize. It was decided that the proceedings of such a meeting had maximum value with rapid publication. We would like to thank the participants for the enthusiasm and goodwill which persisted throughout the meeting both scientifically and socially. Above all we wish to thank H.R.H. The Duchess of Kent for acting as Patron of this meeting.

Section I Immunological Aspects of Inflammation.- 1. The rationale of using levamisole in the treatment of rheumatoid arthritis.- 2. Immunostimulation, levamisole and rheumatoid arthritis.- 3. The effect of cytotoxic drugs on the formation of mononuclear phagocytes.- 4. Rheumatoid factor–immunoglobulin G complex precipitation and neutrophil stimulation: an in vitro model for rheumatoid inflammation.- Chairman’s Summing-up and Future Trends—Immunological aspects of inflammation—the network of interactions.- General Discussion.- Perspectives in Inflammation.- Section II Chronic Inflammation: Cellular Events.- 5. A model for assessing effects of drugs on giranulocyte emigration in vivo.- 6. A polymorph abnormality in Crohn’s disease.- 7. The origin and kinetics of liver macrophages during steady state and inflammation (Abstract).- 8. Lymphocyte-mediated eosinophilia in guinea pigs with delayed hypersensitivity to a chemical.- 9. A role for L-lymphocytes in chronic inflammation.- 10. Cartilage degradation by macrophages, fibroblasts and synovial cells in culture. An in vitro model suitable for studies on rheumatoid arthritis.- 11. Adjuvant arthritis: immune responses and effects of Tilorone or interferon in partially suppressing the disease.- General Discussion.- Chairman’s Summing-up and Future Trends—Cellular reactions in inflammation.- Section III Chronic Inflammation: Mechanisms.- 12. The effect of local elevation of leukocyte cyclic AMP content on lysosomal enzyme release during acute inflammation in vivo.- 13. Recent studies on the secretory activity of mononuclear phagocytes with special reference to prostaglandins.- 14. Interactions of macrophages and complement components in the pathogenesis of chronic inflammation.- 15. Matrix vesicles and apatite nodules in arthritic cartilage.- 16. Crystal induced inflammation and osteoarthritis.- 17. Microanalysis of particulate material involved in inflammation.- 18. The influence of chemical composition of plasma membranes on the functional activities of macrophages.- Opening to Discussion—Mechanisms in chronic inflammation.- General Discussion.- Chairman’s Summing-up and Future Trends.- Section IV General Aspects I.- 19. Dual function of E-type prostaglandins in models of chronic inflammation.- 20. Interactions between prostaglandin E and cyclic nucleotides in chronic inflammatory disease.- 21. The time course of the vascular events associated with inflammation due to ultraviolet irradiation of guinea pig ears.- Perspectives in Inflammation.- 22. Role of macrophages in D-penicillamine-induced stimulation of DNA synthesis in lymph node cells in vitro.- 23. Anti-inflammatory effects of tumour bearing.- 24. Role of platelets and of prostaglandin synthetase on hypotensive effects of arachidonic acid and of carrageenan.- 25. Evidence for a pivotal role of the endoperoxide, PGG2, in inflammatory processes.- 26. Thiols and prostaglandin biosynthesis.- 27. Interactions of non-steroidal anti-inflammatory drugs with substance P-like and gastrointestinal hormones-like polypeptides.- 28. Salicylic acid and proquazone: the differences in absorption and biodistribution explain their different profile of side-effects.- 29. Degradation of bovine nasal cartilage by a neutral protease from human leukocyte granules.- 30. Inhibition of experimental ocular inflammation by topical application of non-steroidal anti-inflammatory drugs (NSAID).- 31. Potentiation of acenocoumarin-induced anticoagulation by a new anti-inflammatory agent in man (Abstract).- 32. In vitro methods for assessing anti-inflammatory drug activity (Abstract).- Section V General Aspects II.- 33. Potentiation of antibody formation by proteases in vitro.- 34. Triggers of prostaglandin release from macrophages.- 35. Biological, chemical and pharmacological induction of the properdin-mediated pathway of complement activation in vitro.- 36. Immune reactions of lymphocytes eluted from rheumatoid inflammatory tissue.- 37. Attempts at producing immune complexes in vitro between isolated macroglobulins and purified IgGs.- 38. Behaviour of some inflammation parameters in plasma and synovial fluid in some rheumatic diseases (Abstract).- 39. Some applications of quantitative two-dimensional immunoelectrophoresis in the study of the systemic acute-phase reaction of the rat.- 40. Restoration of the neutrophil chemotactic responsiveness by levamisole treatment in patients with recurrent infections, eczema and hyperimmunoglobulinaemia E.- 41. Rheumatoid-like joint lesions in rabbits injected intravenously with foreign serum.- 42. Anti-inflammatory activity of some bacterial immunostimulants. Relation with macrophage migration.- 43. Inflammatory exudates and mitogenic activity.- 44. Secretory activity of epithelioid cells.- 45. Vascular changes during acute inflammatory responses in rat hindpaws.- Perspectives in Inflammation.- Section VI Pharmacological Aspects: Animal/Man.- 46. Activators and inhibitors of fibrinolysis in rheumatoid joint inflammation.- 47. Relationships between increased vascular permeability, oedema, hyperalgesia and the effect of non-steroid anti-inflammatory drugs.- 48. Two sites of action of steroids on the prostaglandin system.- 49. Studies on the clinical and laboratory pharmacology of drug formulations of bovine Cu—Zn superoxide dismutases (orgotein).- 50. Humoral control of monocytopoiesis (Abstract).- General Discussion.- Chairman’s Summing-up and Future Trends.- Section VII Pharmacological Aspects: Man/Animal.- 51. Difficulties in the clinical evaluation of new anti-inflammatory drugs.- 52. Is the mechanism of action during treatment of rheumatoid arthritis with penicillamine and gold thiomalate the same?.- 53. About immunological anomalies in treated and non-treated rheumatoid arthritis: rosette test and immunofluorescence of B-cells.- 54. Should penicillamine be prescribed for rheumatoid arthritis?.- 55. Long-term evaluation of intermittent levamisole treatment in rheumatoid arthritis.- General Discussion.- Closing Remarks.- Poster Sessions.