This volume in the Advances in Experimental Medicine and Biology Series is dedicated to developing an overall view of the "state-of� the-art" of knowledge in the field of phospholipase A2 and to exploring the role and function of this enzyme in various inflammatory diseases. This book grew out of two major symposia on phospholipase A2 held in 1989: I). "Phospholipase A2: Pathophysiological Role of Soluble and Membrane-Bound Enzymes" organized by Dr. Doug Morgan and Dr. Ann Welton of Hoffmann-La Roche and sponsored by the New York Academy of Sciences (January 24, 1989). II). "Release and Function of Phospholipase A2 from Inflammatory Cells" organized by Dr. Patrick Wong and Dr. Edward Dennis at the FASEB meeting in New Orleans (March 22, 1989). Readers will find exciting advances in our understanding of the structure, function and molecular biology of phospholipase A2 research which is presented in this volume. The elucidation of gene structures of phospholipase A2 should lead to new insights and new approches in the control and regulation of the enzyme activity. This is primary to better understanding the function of phospholipase A2 and the determination of its activity in cellular and animal systems. Of great importance is the development of animal models for inflammatory disease in order to evaluate the role of phospholipase A2 and its inhibitors. We are convinced that this volume will be an excellent reference that surveys this field in which numerous investigators are currently actively at work.

Contenuti

A. Phospholipase A2 Characterization and Role.- Macrophage Phospholipase A2 Activity and Eicosanoid Production: Studies with Phospholipase A2 Inhibitors in P388D1 Cells.- Localization and Evolution of Two Human Phospholipase A2 Genes and Two Related Genetic Elements.- Structure and Properties of a Secretable Phospholipase A2 from Human Platelets.- Purification and characterization of Phospholipase A2 from Human Osteoarthritic Synovial Fluid.- B. Phospholipase A2 Function.- Phospholipase A2 Activation is the Pivotal Step in the Effector Pathway of Inflammation.- Mobilization and Function of Extracellular Phospholipase A2 in Inflammation.- G-Proteins and Phospholipase Activation in Endothelial Cells.- The Role of Phospholipase A2 Activating Protein (PLAP) in Regulating Prostanoid Production in Smooth Muscle and Endothelial Cells Following Leukotriene D4 Treatment.- C. Disease Models For Inflammation.- Cellular and Extracellular Phospholipase A2 Activity in Zymosan Pleurisy in Rat.- Extracellular Phospholipase A2 Activity in Two In Vivo Models of Inflammation.- Pharmacological Control of Phospholipase A2 Activity In Vivo and In Vitro.- Phospholipase A2 as Leukotriene B4 Secretagogue for Human Polymorphonuclear Leukocytes.- Contributors.

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