Post Genomic Perspectives in Modeling and Control of Breathing is comprised of the proceedings of the IXth Oxford Conference on Modeling and Control of Breathing, held September 13-16, 2003 in Paris, France. This publication is placed within the general framework of post-genomic neurobiology, pathology, and the precise example of the rhythmic respiratory neural assembly being used to understand how genetic networks have been selected and conserved in the vertebrate brain. Specific topics include: ion channels and synapses responsible for respiratory rhythmogenesis and plasticity; pre- and post-natal development of the respiratory rhythm; chemosensory transduction and chemo-afferent signalling. These valuable insights open new avenues as to why the genetic codes underlying a vital function such as breathing have been selected, conserved, or optimized during evolution – a major issue of post-genomic biology. This critical issue will be considered from both top-down and bottom-up integrative modeling standpoints, with a view to elucidating the functional genomics linking discrete molecules to the integrated system that regulates breathing.
Views on the Human Breathing Behavior.- Different Profile in Ventilatory vs. Respiratory Sensation Responses to CO2 with Varying Po2.- Amygdala and Emotional Breathing in Humans.- Immediate Effects of Bilateral Carotid Body Resection on Total Respiratory Resistance and Compliance in Humans.- Memories of Yoshiyuki Honda, MD, PhD.- Memories of Dr. Yoshiyuki Honda.- Mechanisms of Central and Carotid Bodies Chemoreception.- Chemosensory Control of the Respiratory Function.- Brainstem NHE-3 Expression and Control of Breathing.- Functional Connection From the Surface Chemosensitive Region to the Respiratory Neuronal Network in the Rat Medulla.- Chemosensory Inputs and Neural Remodeling in Carotid Body and Brainstem Catecholaminergic Cells.- Role of Fe2+ in Oxygen Sensing in the Carotid Body.- Ventilatory Responsiveness to CO2 Above & Below Eupnea: Relative Importance of Peripheral Chemoreception.- Carotid Body Tumors in Humans Caused by a Mutation in the Gene for Succinate Dehydrogenase D (SDHD).- A SIDS-Like Phenotype is Associated With Reduced Respiratory Chemoresponses in PACAP Deficient Neonatal Mice.- Selective Alteration of the Ventilatory Response to Hypoxia Results from Mutation in the Myelin Proteolipid Protein Gene.- From Neurons to Neural Assemblies: Brainstem Control of Rhythm Generation.- Organization of Central Pathways Mediating the Hering-Breuer Reflex and Carotid Chemoreflex.- Converging Functional and Anatomical Evidence for Novel Brainstem Respiratory Compartments in the Rat.- Eupneic Respiratory Rhythm in Awake Goats is Dependent on an Intact Pre-Bötzinger Complex.- BDNF Preferentially Targets Membrane Properties of Rhythmically Active Neurons in the pre-Bötzinger Complex in Neonatal Mice.- Ionic Currents and Endogenous Rhythm Generation in the pre-Bötzinger Complex: Modelling and In Vitro Studies.- Modulation of Inspiratory Inhibition of the Bötzinger Complex by Raphe Pallidus and Locus Coeruleus in Rabbits.- Behavioural Control of Breathing in Mammals: Role of the Midbrain Periaqueductal Gray.- Breathing at Birth: Influence of Early Developmental Events.- From Molecular to Integrated Neural Control of Breathing.- A Dual-Role Played by Extracellular ATP in Frequency-Filtering of the Nucleus Tractus Solltarii Network.- Role of GABA in Central Respiratory Control Studied in Mice Lacking GABA-Synthesizing Enzyme 67-kDa Isoform of Glutamic Acid Decarboxylase.- Breathing Without Acetylcholinesterase.- In-Silico Model of NMDA and Non-NMDA Receptor Activities Using Analog Very-Large-Scale Integrated Circuits.- Respiratory Role of Ionotropic Glutamate Receptors in the Rostral Ventral Respiratory Group of the Rabbit.- Serotonergic Receptors and Effects in Hypoglossal and Laryngeal Motoneurons.- Modelling Respiratory Rhythmogenesis: Focus on Phase Switching Mechanisms.- Respiratory Activity During Sleep and Anesthesia.- Ventilatory Instability Induced by Selective Carotid Body Inhibition in the Sleeping Dog.- Stability Analysis of the Respiratory Control System During Sleep.- A Physical Model of Inspiratory Flow Limitation in Awake Healthy Subjects.- Antioxidants Prevent Blunting of Hypoxic Ventilatory Response by Low-Dose Halothane.- Mechanism of Propofol-Induced Central Respiratory Depression in Neonatal Rats.- Interaction of Arousal States with Depression of Acute Hypoxic Ventilatory Response by 0.1 MAC Halothane.- Cardio-Respiratory Regulations and Cerebral Blood Flow.- Relationship Between Ventilatory and Circulatory Responses to Sustained Mild Hypoxia in Humans.- Respiratory, Cerebrovascular and Pressor Responses to Acute Hypoxia: Dependency on Pet Co 2.- Can Cardiogenic Oscillations Provide an Estimate of Chest Wall Mechanics?.- Nonlinear Modeling of the Dynamic Effects of Arterial Pressure and Blood Gas Variations on Cerebral Blood Flow in Healthy Humans.- Ventilatory Response to Exercise.- Mixed Venous CO2 and Ventilation During Exercise and CO2-Rebreathing in Humans.- Effects of Pain and Audiovisual Stimulation on the Hypoxic Ventllatory Response.- Effect of Progressive Hypoxia with Moderate Hypercapnia on Ventilatory vs. Respiratory Sensation Responses in Humans.- Frequency Response of the Input Reaching the Respiratory Centres During Moderate Intensity Exercise.- Variability and Plasticity of Breathing.- Effects of Resistive Loading on Breathing Variability.- Effects of Intermittent Hypoxic Training and Detraining on Ventilatory Chemosensitive Adaptations in Endurance Athletes.- Effects of 5 Consecutive Nocturnal Hypoxic Exposures on Respiratory Control and Hematogenesis in Humans.- Memory, Reconsolidation and Extinction in Lymnaea Require the Soma of RPeD1.- Conclusions and Perspectives.- Modeling and Control of Breathing: Perspectives from Pre- to Post-Genomic Era.- Post-Genomic Perspectives in Modeling and Control of Breathing.
