Post-translational modifications and associations in the IGF system

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ISBN 10: 3659192295 / ISBN 13: 9783659192296

Editore: LAP LAMBERT Academic Publishing Mär 2014, 2014

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Neuware -The incidence of cancer, diabetes mellitus, cardiovascular and some other diseases continues to increase and there are still no sufficiently successive healing and preventive strategies. Insulin-like growth factors (IGFs) play important roles during entire life and, depending on the biochemical pathway in which they are involved, they may be regarded as growth factors, hormones or cytokines. IGFs exert their functions after binding to specific receptors and their availability is regulated by IGF-binding proteins. Altered activity in the IGF signaling pathways is connected with diseases, but data are controversial as both beneficial and harmful effects of IGFs were recorded. Traditional approaches to study biochemical pathways, mostly based on the synthesis and clearance rates, are not sufficient. Post-translational protein modifications and associations with other biomolecules may represent an intermediate level of control, which deserves more attention. This book provides an overview of the post-translational events which affect the IGF system, offering experimental data to document structural and functional changes which, as a final consequence, have altered IGF activity.Books on Demand GmbH, Überseering 33, 22297 Hamburg 156 pp. Englisch. Codice articolo 9783659192296

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Titolo: Post-translational modifications and ...

Casa editrice: LAP LAMBERT Academic Publishing Mär 2014

Data di pubblicazione: 2014

Legatura: Taschenbuch

Condizione: Neu

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Riassunto:

The incidence of cancer, diabetes mellitus, cardiovascular and some other diseases continues to increase and there are still no sufficiently successive healing and preventive strategies. Insulin-like growth factors (IGFs) play important roles during entire life and, depending on the biochemical pathway in which they are involved, they may be regarded as growth factors, hormones or cytokines. IGFs exert their functions after binding to specific receptors and their availability is regulated by IGF-binding proteins. Altered activity in the IGF signaling pathways is connected with diseases, but data are controversial as both beneficial and harmful effects of IGFs were recorded. Traditional approaches to study biochemical pathways, mostly based on the synthesis and clearance rates, are not sufficient. Post-translational protein modifications and associations with other biomolecules may represent an intermediate level of control, which deserves more attention. This book provides an overview of the post-translational events which affect the IGF system, offering experimental data to document structural and functional changes which, as a final consequence, have altered IGF activity.

L'autore:

Principal researcher in the Institute for the Application of Nuclear Energy, University of Belgrade, Serbia. PhD in Biochemistry. Research field: insulin and insulin-like growth factors in metabolic control associated with specific nutritional regime, physical activity, physiological status (ageing, pregnancy) and diseases.