Principles and Practice of Pediatric Infectious Diseases

Authoritative, comprehensive, and practical, this second edition covers the infectious diseases of childhood and is organized by syndrome as well as organism. Written by the premier authorities on the subject, it contains a wealth of pertinent information and has been called the best, most useful textbook in the field today. Clinically and therapeutically oriented, it includes sections on understanding, controlling, and preventing infectious disease; clinical syndromes and cardinal features; etiologic agents of disease; and lab diagnosis and therapy.

• Comprehensive information is authoritative and readily accessible.
• Content is offered for diagnosis, management, and prevention of any infectious disease - not in multiple volumes, but in a single source.
• Specific content is included on infection control, immunizations, understanding biostatistics, testing and using antimicrobial agents.
• Content is clinically and therapeutically oriented with three problem - solving approaches and three goals ¯ understanding the problem, diagnosing correctly, and providing appropriate management.
• The textbook outline and content provide excellent curriculum for study and match content specifications for the ABP subspecialty certifying examination.
• The generous use of tables, graphics, and pictorials delivers major points, offers quick review, and facilitates slide making for lectures.
• The editors and authors of each content area are highly recognizable experts from recommending bodies ¯ resulting in consistency and standard - of - care approaches throughout the text.
• Carefully written and edited, it offers a uniform focus, with minimum redundancy or extraneous information.

• Content has been thoroughly reviewed and extensively updated throughout.
• New insights are offered into the global perspective on emergence and control of infectious diseases and antimicrobial resistance.
• Other new or expanded information includes the use of immunoglobulin products, a primer in biostatistics, inflammatory mediators, the latest schedule of immunizations, spongiform encephalopathies, recently discovered viruses, new antiviral therapies, new vaccine, fungal pathogens, and anti-infective agents.
• A pictorial compendium of arthropods and associated diseases has been added.
• Websites and telephone numbers are included for key resources.
• Tables, figures, slide - ready graphics, clinical photographs, and the latest imaging pictorials have been maximized to improve their usefulness.

PART I
Understanding, Controlling, and Preventing Infectious Diseases

SECTION A. EPIDEMIOLOGY AND CONTROL OF INFECTIOUS DISEASES

1. Perspectives on Emergence and Control of Infectious Diseases Worldwide
2. Principles of Epidemiology and Public Health
3. Pediatric Infection Control
4. Infectious Diseases Associated with Out-of-Home Childcare
5. Infectious Diseases in Immigrant and Internationally Adopted Children

SECTION B. PREVENTION OF INFECTIOUS DISEASES

6. Passive Immunization
7. Active Immunization
8. Chemoprophylaxis
9. Protection of Travelers
10. Human Milk and Infectious Diseases

PART II
Clinical Syndromes and Cardinal Features of Infectious Diseases: Approach to Diagnosis and Initial Management

SECTION A. FEVER, BACTEREMIA, AND SEPTICEMIA

11. Genesis of Fever and the Inflammatory Response
12. The Systemic Inflammatory Response Syndrome, Sepsis, and Septic Shock
13. Toxic Shock Syndrome

SECTION B. CARDINAL SYMPTOM COMPLEXES

14. Mucocutaneous Symptom Complexes
15. Fever without Localizing Signs
16. Fever of Unknown Origin and Periodic Fever
17. Lymphatic System and Generalized Lymphadenopathy
18. Respiratory Tract Symptom Complexes
19. Abdominal Symptom Complexes
20. Neurologic Symptom Complexes
21. Musculoskeletal Symptom Complexes

SECTION C. UPPER RESPIRATORY TRACT AND ORAL INFECTIONS

22. Infections of the Oral Cavity
23. Cervical Lymphadenitis and Neck Infections
24. The Common Cold
25. Pharyngitis
26. Supraglottic Infections
27. Otitis Media
28. Otitis Externa and Malignant Otitis Externa
29. Mastoiditis
30. Sinusitis
31. Laryngeal and Subglottic Infections

SECTION D. LOWER RESPIRATORY TRACT INFECTIONS

32. Bronchiolitis
33. Acute Uncomplicated Pneumonia
34. Complications of Acute Pneumonia
35. Persistent and Recurrent Pneumonia
36. Pneumonia in the Immunocompromised Host
37. Mediastinal and Hilar Lymphadenopathy

SECTION E. CARDIAC AND VASCULAR INFECTIONS

38. Endocarditis and Intravascular Infections
39. Myocarditis
40. Pericarditis

SECTION F. CENTRAL NERVOUS SYSTEM INFECTIONS

41. Acute Bacterial Meningitis Beyond the Neonatal Period
42. Chronic Meningitis
43. Recurrent Meningitis
44. Aseptic and Viral Meningitis
45. Encephalitis, Meningoencephalitis, and Postinfectious Encephalomyelitis
46. Cerebellar Ataxia, Transverse Myelitis and Myelopathy, Guillain-Barré Syndrome, Neuritis, and Neuropathy
47. Focal Suppurative Infections of the Central Nervous System
48. Eosinophilic Meningitis
49. Spongiform Encephalopathies: Slow Infections of the Nervous System
50. Reye Syndrome

SECTION G. GENITOURINARY TRACT INFECTIONS

KIDNEY AND URINARY TRACT

51. Urinary Tract InfectionsDowns,
52. Renal (Intrarenal and Perinephric) Abscess

REPRODUCTIVE ORGANS AND GENITAL TRACT

53. Sexually Transmitted Disease Syndromes
54. Skin and Mucous Membrane Infections and Inguinal Lymphadenopathy
55. Urethritis, Vulvovaginitis, and Cervicitis
56. Pelvic Inflammatory Disease
57. Epididymitis, Orchitis, and Prostatitis
58. Infectious Diseases of Child Abuse

SECTION H. GASTROINTESTINAL TRACT INFECTIONS AND INTOXICATIONS

59. Approach to Diagnosis and Management of Gastrointestinal Tract Infections
60. Viral Gastroenteritis
61. Inflammatory Enteritis
62. Milk Intolerance, Eosinophilic Enteritis, and Chronic Diarrhea
63. Necrotizing Enterocolitis
64. Foodborne and Waterborne Disease

SECTION I. INTRA-ABDOMINAL INFECTIONS

65. Acute Hepatitis
66. Chronic Hepatitis
67. Granulomatous Hepatitis
68. Acute Pancreatitis
69. Cholecystitis and Cholangitis
70. Peritonitis
71. Appendicitis and Mesenteric Lymphadenitis
72. Intra-Abdominal, Visceral, and Retroperitoneal Abscesses
73. Abdominal and Retroperitoneal Lymphadenopathy

SECTION J. SKIN AND SOFT TISSUE INFECTIONS

74. Cellulitis and Superficial Skin Infections
75. Erythematous Macules and Papules
76. Vesicles and Bullae
77. Purpura
78. Urticaria and Erythema Multiforme
79. Papules, Nodules, and Ulcers
80. Subcutaneous Tissue Infections and Abscesses
81. Myositis and Pyomyositis
82. Localized Lymphadenitis, Lymphadenopathy, and Lymphangitis

SECTION K. BONE AND JOINT INFECTION

83. Osteomyelitis
84. Infectious and Inflammatory Arthritis
85. Diskitis
86. Transient Synovitis

SECTION L. EYE INFECTIONS

87. Conjunctivitis in the Neonatal Period (Ophthalmia Neonatorum
88. Conjunctivitis Beyond the Neonatal Period
89. Infective Keratitis
90. Uveitis and Chorioretinitis
91. Endophthalmitis
92. Periorbital and Orbital Infections

SECTION M. INFECTIONS RELATED TO TRAUMA

93. Infection Following Trauma
94. Infection Following Burns
95. Infection Following Bites

SECTION N. INFECTIONS OF THE FETUS AND NEWBORN

96. Immunologic Development and Susceptibility to Infection
97. Clinical Approach to the Infected Neonate
98. Bacterial Infections in the Neonate
99. Viral Infections in the Fetus and Neonate
100. Nosocomial Infections in the Neonate

SECTION O. INFECTIONS AND TRANSPLANTATION

101. Infections in Solid Organ Transplant Recipients
102. Infections in Hematopoietic Stem Cell Transplant Recipients

SECTION P. INFECTIONS AND CANCER

103. Fever and Granulocytopenia
104. Infections in Children with Cancer

SECTION Q. INFECTIONS ASSOCIATED WITH HOSPITALIZATION

105. Clinical Syndromes of Hospital-Associated

SECTION R. INFECTIONS ASSOCIATED WITH MEDICAL DEVICES

106. Clinical Syndromes of Device-Associated Infections

SECTION S. INFECTIONS IN PATIENTS WITH DEFICIENT DEFENSES

107. Evaluation of the Child with Suspected Immunodeficiency
108. Infectious Complications of Antibody Deficiency
109. Infectious Complications of Complement Deficiencies
110. Infectious Complications of Dysfunction or Deficiency of Polymorphonuclear and Mononuclear Phagocytes
111. Infectious Complications of Cell-Mediated Immunity: Primary Immunodeficiencies
112. Infectious Complications in Special Hosts

SECTION T. HUMAN IMMUNODIFICIENCY VIRUS AND THE ACQUIRED IMMUNODEFICIENCY SYNDROME

113. Epidemiology of HIV Infection in Children and Adolescents
114. Immunopathogenesis of HIV-l Infection
115. Clinical Manifestations of HIV Infection
116. Infectious Complications of HIV Infection
117. Detection of HIV-l Infection.
118. Management of HIV Infection
119. Prevention of HIV Infection
120. HIV in the Health Care Setting

Part III
Etiologic Agents of Infectious Diseases

SECTION A. BACTERIA

121. Classification of Bacteria

GRAM-POSITIVE COCCI

122. Staphylococcus aureus
123. Staphylococcus epidermidis and Other Coagulase-Negative Staphylococci
124. Classification of Streptococci
125. Streptococcus pyogenes (Group A Streptococcus
126. Nonsuppurative Post-Streptococcal Diseases: Rheumatic Fever and Acute Glomerulonephritis
127. Streptococcus agalactiae (Group B Streptococcus
128. Enterococcus Species
129. Viridans Streptococci, Streptococcus bovis, and Abiotrophia Species
130. Groups C and G Streptococci
131. Streptococcus pneumoniae
132. Other Gram-Positive, Catalase-Negative Cocci: Leuconostocs and Pediococci

GRAM-NEGATIVE COCCI

133. Neisseria meningitidis
134. Neisseria gonorrhoeae
135. Other Neisseria Species
136. Moraxella catarrhalis

GRAM-POSITIVE BACILLI

137. Arcanobacterium haemolyticum
138. Bacillus Species (Anthrax
139. Corynebacterium diphtheriae
140. Other Corynebacteria
141. Erysipelothrix rhusiopathiae
142. Gardnerella vaginalis
143. Listeria monocytogenes
144. Other Gram-Positive Bacilli
145. Mycobacterium tuberculosis
146. Non - Tuberculosis Mycobacterium Species
147. Nocardia Species Enterrobacteriaceae: Gram - Negative Bacilli
148. Citrobacter Species
149. Edwardsiella tarda
150. Enterobacter and Pantoea SpeciesMarcon
151. Escherichia coli
152. Klebsiella Species
153. Proteus, Providencia, and Morganella Species
154. Serratia Species
155. Salmonella Species
156. Shigella Species
157. Yersinia Species
158. Less Common Enterobacteriaceae

NONENTEROBACTERIACEAE: GRAM-NEGATIVE BACILLI

159. Acinetobacter Species
160. Aeromonas Species
161. Less Common Nonenterobacteriaceae
162. Eikenella corrodens J. Marcon
163. Flavobacteriaceae
164. Moraxella and Psychrobacter Species
165. Pasteurella Species
166. Plesiomonas shigelloides Cleary
167. Pseudomonas Species and Related Organisms
168. Pseudomonas aeruginosa
169. Burkholderia cepacia Complex and Other Burkholderia Species
170. Stenotrophomonas maltophilia
171. Vibrio cholerae(CholeraTauxe)
172. Other Vibrio Species
173. Other Nonenterobacteriaceae

GRAM-NEGATIVE COCCOBACILLI

174. Bartonella Species (Cat-Scratch Disease, Bacillary Angiomatosis, Bacillary Peliosis)
175. Brucella Species (Brucellosis)
176. Bordetella pertussis (Pertussis) and Other Species
177. Calymmatobacterium granulomatsis (Granuloma Inguinale
178. Campylobacter jejuni
179. Other Campylobacter Species
180. Capnocytophaga Species
181. Chlamydophila (Chlamydia) pneumoniae
182. Chlamydia trachomatis
183. Chlamydophila (Chlamydia) psittaci (Psittacosis)
184. Coxiella burnetti (Q Fever)
185. Ehrlichia Species (the Ehrlich...