Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics

Lingua: inglese

Editore: ACADEMIC, 2014

0198709021 / 9780198709022

Da: AHA-BUCH GmbH, Einbeck, GermaniaAHA-BUCH GmbH

Venditore con 5 stelle

Venditore AbeBooks dal 14 agosto 2006

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nach der Bestellung gedruckt Neuware - Printed after ordering - Nowadays bioinformaticians and geneticists are faced with myriad high-throughput data usually presenting the characteristics of uncertainty, high dimensionality and large complexity.These data will only allow insights into this wealth of so-called 'omics' data if represented by flexible and scalable models, prior to any further analysis. At the interface between statistics and machine learning, probabilistic graphical models (PGMs) represent a powerful formalism to discover complex networks of relations.These models are also amenable to incorporating a priori biological information. Network reconstruction from gene expression data represents perhaps the most emblematic area of research where PGMs have been successfully applied. However these models have also created renewed interest in genetics in the broad sense, in particular regarding association genetics, causality discovery, prediction of outcomes, detection of copy number variations, and epigenetics. This book provides an overview of theapplications of PGMs to genetics, genomics and postgenomics to meet this increased interest.A salient feature of bioinformatics, interdisciplinarity, reaches its limit when an intricate cooperation between domain specialists is requested. Currently, few people are specialists in the design of advanced methods using probabilistic graphical models for postgenomics or genetics. This book deciphers such models so that their perceived difficulty no longer hinders their use and focuses on fifteen illustrations showing the mechanisms behind the models.Probabilistic Graphical Models for Genetics, Genomics and Postgenomics covers six main themes:(1) Gene network inference(2) Causality discovery(3) Association genetics(4) Epigenetics(5) Detection of copy number variations(6) Prediction of outcomes from high-dimensional genomic data.Written by leading international experts, this is a collection of the most advanced work at the crossroads of probabilistic graphical models and genetics, genomics, and postgenomics. The self-contained chapters provide an enlightened account of the pros and cons of applying these powerful techniques.…

Codice articolo 9780198709022

Titolo
Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics
Autore
Christine Sinoquet
Editore
ACADEMIC
Anno di pubblicazione
2014
Condizione
Neu
Rilegatura
Buch
Lingua
inglese
ISBN 10
0198709021
ISBN 13
9780198709022
Peso dell'articolo
1124 grammi
Dimensioni
252x194x30 mm

AHA-BUCH GmbH

Einbeck, Germania

Venditore con 5 stelle

Venditore AbeBooks dal 14 agosto 2006

Tariffe di spedizione da Germania a U.S.A.

ArticoloDa 7 a 10 giorni lavorativiDa 5 a 7 giorni lavorativi
Primo articoloEUR 42,87EUR 58,49
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