Protein Phosphorylation

Claude Prigent

ISBN 10: 9535136259 / ISBN 13: 9789535136255

Editore: Intechopen Nov 2017, 2017

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Neuware -Protein phosphorylation reactions are carried out in a cell by protein kinases, which predominantly use ATP as a phosphate donor that is transferred and covalently bound to an amino acid on a substrate protein. Protein phosphorylation was discovered in 1954 by Edmond Fischer who shared the Nobel Prize in Medicine or Physiology in 1992 with Edwin Krebs. There are so many kinases that one was called 'Just Another Kinase' for JAK kinase. Their counterpart is protein phosphatases that remove phosphates from phosphorylated proteins. Kinases and phosphatases act as switches in the cell that activates or inactivates protein functions. These reactions are reversible; the cell can quickly react to a situation but can then go back to its initial state.Books on Demand GmbH, Überseering 33, 22297 Hamburg 204 pp. Englisch.

Codice articolo 9789535136255

Dati bibliografici

• Titolo: Protein Phosphorylation
• Editore: Intechopen Nov 2017
• Data di pubblicazione: 2017
• Lingua: Inglese
• ISBN 10: 9535136259
• ISBN 13: 9789535136255
• Rilegatura: Buch
• Condizione: Neu
• Dimensioni: 266 L x 185 A x 19 P (millimetri) 266 millimetri di larghezza per 185 millimetri di altezza per 19 millimetri di profondità
• Peso: 659 grammi

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Riassunto

Protein phosphorylation reactions are carried out in a cell by protein kinases, which predominantly use ATP as a phosphate donor that is transferred and covalently bound to an amino acid on a substrate protein. Protein phosphorylation was discovered in 1954 by Edmond Fischer who shared the Nobel Prize in Medicine or Physiology in 1992 with Edwin Krebs. There are so many kinases that one was called "Just Another Kinase" for JAK kinase. Their counterpart is protein phosphatases that remove phosphates from phosphorylated proteins. Kinases and phosphatases act as switches in the cell that activates or inactivates protein functions. These reactions are reversible; the cell can quickly react to a situation but can then go back to its initial state.