Rheumatology e-dition: Text with Continually Updated Online Reference, 2-Volume Set

This latest edition continues the tradition of excellence of previous editions with comprehensive, authoritative coverage of rheumatic disease from basic scientific principles to practical points of clinical management. Internationally renowned authors deliver essential information on the definition of a disease, epidemiology, pathophysiology, clinical findings, differential diagnosis, and disease management. A consistent style and lavishly illustrated full-color format presents you with comprehensive clinical and scientific information in a lucid, logical, user-friendly manner. This e-dition includes the printed text as well as access to the complete contents online, fully searchable, plus weekly content updates, links to PubMed and CrossRef, outcome measurement tools, classification criteria, self assessment tools, and more. A must have for all practitioners in the field!

• Find complete coverage of all major disorders of the musculoskeletal system in complete, self-contained chapters.

• Get fresh insights and perspectives on rheumatic disease with 30% new contributors.
• Stay ahead of the curve with new chapters addressing principles of innate immunity, signal transduction, pharmacogenetics, and more.
• Incorporate the very latest principles of immunobiology and inflammatory processes into your decision making.
• Use the new section on Imaging in Rheumatic Disease to get the very latest information on the role of various imaging modalities in the diagnosis and management of disease progression.
• Take advantage of unprecedented reference power with this multimedia E-dition with access to the complete contents online, fully searchable, plus weekly content updates, links to PubMed and CrossRef, downloadable illustrations, outcome measurement tools, classification criteria, self assessment tools, and more.

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Section 1: The Scientific Basis of Rheumatic Disease

*Epidemiologic Concepts and Classification of Rheumatology
*Principles of Outcome Assessment
*The Worldwide Economic and Functional Impact of *Rheumatic Disorders and Pharmaconomics
*Principles of Health Economics and Application to Rheumatic Disorders and Pharmaconomics
*The Musculoskeletal System and Joint Physiology
*Anatomy and Biomechanics of the Spine
*Biomechanics of Peripheral Joints
*The Synovium

Articular cartilage

*Bone Structure and Function
*Molecular Biology

Signal Transduction

*Genetic Factors in rheumatic disease
*Principles of adaptive immunity

Principles of Innate Immunity

*Tissue Destruction and Repair
*Neuropeptides, Free Radicals and Inflammation

Scientific Basis of Pain

Pharmacogenomics

Section 2: Evaluation: Signs and Symptoms

*History and Physical Examination
*Pattern Recognition Arthritis
*Laboratory Tests in Rheumatic Disorders
*Synovial Fluid Analysis
*Minimally Invasive Procedures
*Skin and Rheumatic Disease
*The Eye and Rheumatic disease
*The Heart in Rheumatic Disease
*The Lung in Rheumatic Disease
*Gastrointestinal Tract and Rheumatic Disease
*The Kidney and Rheumatic Diseases

Section 3: Evaluation Imaging Techniques

Conventional Radiography and CT

MRI

Ultrasound

*DXA and Measurement of Bone

Section 4: Principles of Management

*Health Promotion and Patient Education for People with Arthritis

Nutrition

*Principles of Opiate Management
*NSAIDS
*Systemic Corticosterioids in Rheumatology
*Aspiration and Injection of Joints
*Antimalarials and Gold
*Sulfasalazine
*Methotrexate

Leflunomide

*Immunosuppressives
*Immunotherapies: T cell, B cell cCmplement

Other drugs in Rheumatic Disease

Cytokine neutralizers: IL1 inhibitors

*Cytokine Neutralizers: TNF alpha
*Emerging Therapeutic Targets; Small Molecules

Emerging Therapeutic Targets; IL6, IL15, IL18, IL23, etc

*Antibiotics
*Drugs and Pregnancy
*Alternative and Complementary Medicine
*Principles of Rehabilitiation
*Principles of Arthritis Surgery

Section 5: Regional and Widespread Pain

*Neck Pain
*Low Back Pain and Lumbar Spinal Stenosis
*The Shoulder
*The Elbow
*The Wrist and Hand
*The Hip
*The Knee
*The Ankle
*Temporomandibular Pain Syndrome
*Fibromyalgia and related Syndromes
*Entrapment neuropathies and Compartment Syndromes
*Algodystrophy/reflex Sympathetic Dystrophy Syndrome
*Sports Medicine: the Clinical Spectrum of Injury

Section 6: Rheumatoid Arthritis and Other Synovial Disorders

*Antiquity of RA
*Classification of RA
*Extra-articular Features of RA and Systemic Involvement
*Adult Stills Disease
*Imaging of RA
*Genetics of the Major Histocompatiablity Complex in RA
*Animal models of RA
*Autoantibodies in RA
*Cellular immunity in RA
*Angiogenesis in RA
*Rheumatoid Synovitis and Pannus
*Evaluation and Management of Early Inflammatory Polyarthritis
*Evaluation and Outcome of the Patient with Established RA
*Management of RA: synovitis
*Management of Extra-articular disease and Complications
*Multidisciplinary Approach to RA

Section 7: Pediatric Rheumatology

*History of Pediatric Rheumatology
*Classification and Epidemiology of Juvenile Inflammatory Arthritis
*Clinical Features, Special problems and Presentations in Children
*Etiology and Pathogenesis of JRA
*Evaluation of Musculoskeletal Complaints in Children
*Management of Juvenile Idiopathic Arthritis
*Connective Tissue Diseases in Children
*Legg-Perthes and other Hip Disease in Children
*Rehabilitation and Psychosocial Issues

Section 8: Infection-related rheumatic diseases

*Septic Arthritis, Osteomyelitis, Gonococcal and Syphilitic Arthritis
*Mycobacterial, Brucella, Fungal and Parasitic Arthritis
*Lyme Disease
*Viral Arthritis
*Rheumatic Aspects of HIV Infection and other Immunodeficient States
*Acute Rheumatic Fever

Reactive Arthritis: Etiology and Pathogenesis

Reactive Arthritis: Clinical Features and Treatment

Section 9: Spondyloarthropathies

*Antiquity of Spondyloarthropathies
*Classification and Epidemiology of Spondylitis
*Clinical features of Ankylosing Spondylitis

Etiology, Pathogenesis and Pathology of Ankylosing Spondylitis

*Seronegative Spondyloarthropathies: Imaging
*Management of Ankylosing Spondylitis
*Psoriatic Arthritis: Clinical Feature
*Psoriatic Arthritis Etiology and Pathogenesis
*Psoriatic Arthritis: Management
*Enteropathic Arthropathies: Diagnosis and Treatment
*Enthesopathy

Section 10: Connective Tissues Disorders

Systemic Lupus Erythematosus

*History
*Epidemiology and classification
*Immunopathology
*Genetics of Lupus
*The Complement System
*Autoantibodies in SLE
*Cellular immunology in SLE
*Clinical features of SLE
*Drug-induced Lupus
*Assessing Disease Activity and Outcome in SLE
*Treatment of Non-Renal Lupus
*Treatment - Renal Involvement

Pregnancy in SLE and Neonatal Lupus

*Sjögrens syndrome
*Antiphospholipid Syndrome: Diagnosis and Management

Systemic Sclerosis

*Epidemiology and Classification of Scleroderma
*Assessing Disease activity and outcome in scleroderma
*Clinical features of scleroderma
*Etiology and pathogenesis of systemic sclerosis
*Management of scleroderma
*Raynaud's Phenomenon
*Localized Scleroderma and Idiopathic and *Environmentally Induced Scleroderma Variants

Inflammatory Muscle Disease

*Clinical Features, Classification and Epidemiology of Inflammatory Disease
*Etiology and Pathogenesis of Inflammatory Disease
*Management of Inflammatory Muscle Disease
*Metabolic and Drug Induced Myopathies
*Overlap Syndromes

Section 11: The Vasculitides

*Classification and Epidemiology of Inflammatory Vascular Diseases

Biology and Immunopathogenesis of Vasculitis

*Polyarteritis Nodosa and Microscopic Polyangiitis
*Polymyalgia Rheumatica and Giant Cell Arteritis
*Wegener's Granulomatosis and Lymphamatoid Granulomatosis
*Churg-Strauss syndrome
*Takayasu's arteritis
*Behçet's syndrome
*Kawasaki Disease
*Henoch-Shönlein Purpura
*Panniculitis and Cutaneous Vasculitis
*Cryoglobulinemia and Franklin Syndrome
*Primary Angiitis of the CNS

SECTION 12: Other Systemic Illnesses

*Cogan's syndrome
*Sarcoidosis
*Relapsing Polychondritis
*Miscellaneous Arthropathies including Synovial tumors and Foreign Body Synovitis
*The Amyloidoses
*Clubbing and Hypertrophic Osteoarthropathy

SECTION 13: Osteoarthritis and Related Disorders

*Epidemiology and Classification of OA
*Clinical features of OA
*Osteoarthritis: Pathology and Pathogenesis
*Genetics of Osteoarthritis
*Imaging of OA
*Evaluation of the Patient with OA and Measurement of Outcomes
*Management of Limb Osteoarthritis
*Diffuse Idiopathic Skeletal Hyperstosis
*Neuropathic Arthropathy
*Osteonecrosis

Rare OA: Ochronosis, Kashanbeck, Castleman's Disease

Section 14: Crystal-related arthropathies

*Epidemiology, Classification and History of Crystal-related Arthropathies
*Etiology and Pathogenesis of Gout
*Clinical Features of Gout
*The Management of Gout
*Calcium Pyrophosphate Dihydrate Crystal-Associated Arthropathy
*Basic Calcium Phosphate Crystal Deposition Disease
*Other Crystal Associated Arthropathies

Section 15: Endocrine and Hemoglobin-related Arthritis and Storage Diseases

Rheumatoid Manifestations of Endocrine Disease

*Dialysis Arthropathy
*Primary Hyperlipidemias and Xanthomas
*Hemophilia and other Bleeding Disorders
*Joint and Bone Lesions in Hemoglobinopathies
*Hemochromatosis

Section 16 Metabolic Bone Diseases

*Epidemiology, Classification and History of Osteoporosis
*Clinical Features of Osteoporosis
*Pathogeneis of Osteoporosis
*Investigations of Bone: biochemical markers
*Management of Osteoporosis
*Glucocorticoid-induced osteoporosis
*Rickets and Osteomalacia
*Hyperparathryoidsm
*Renal osteodystrophy
*Paget's Disease of Bone

Section 17: Heritable disease and tumors of bone and connective tissue

*Gaucher's Disease
*Mucopolysaccharidoses
*Heritable Collagen Disorders
*Hypermobility Syndrome
*Skeletal Dysplasias
*Tumors of Bone