The Role of Model Integration in Complex Systems Modelling: An Example from Cancer Biology

Patel, Manish I.; Nagl, Sylvia

ISBN 10: 3642156029 / ISBN 13: 9783642156021

Editore: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG, 2010

With no similar books on the market, this volume is a welcome addition. Many current methods use 'shallow integration' that employ output-input linking. This book goes further, setting out a systems biology and tumour modeling method called 'deep integration'. Series: Understanding Complex Systems. Num Pages: 178 pages. BIC Classification: MJCL; PHS; PSA; TBC. Category: (P) Professional & Vocational. Dimension: 242 x 164 x 18. Weight in Grams: 450. . 2010. Hardback. . . . . Codice articolo V9783642156021

Riassunto:

Model integration – the process by which different modelling efforts can be brought together to simulate the target system – is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale.

A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules.

The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.

Dalla quarta di copertina:

Model integration the process by which different modelling efforts can be brought together to simulate the target system is a core technology in the field of Systems Biology. In the work presented here model integration was addressed directly taking cancer systems as an example. An in-depth literature review was carried out to survey the model forms and types currently being utilised. This was used to formalise the main challenges that model integration poses, namely that of paradigm (the formalism on which a model is based), focus (the real-world system the model represents) and scale.

A two-tier model integration strategy, including a knowledge-driven approach to address model semantics, was developed to tackle these challenges. In the first step a novel description of models at the level of behaviour, rather than the precise mathematical or computational basis of the model, is developed by distilling a set of abstract classes and properties. These can accurately describe model behaviour and hence describe focus in a way that can be integrated with behavioural descriptions of other models. In the second step this behaviour is decomposed into an agent-based system by translating the models into local interaction rules.

The book provides a detailed and highly integrated presentation of the method, encompassing both its novel theoretical and practical aspects, which will enable the reader to practically apply it to their model integration needs in academic research and professional settings. The text is self-supporting. It also includes an in-depth current bibliography to relevant research papers and literature. The review of the current state of the art in tumour modelling provides added value.

Dati bibliografici

Titolo: The Role of Model Integration in Complex ...
Casa editrice: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Data di pubblicazione: 2010
Legatura: Rilegato
Condizione: New