SCN2A-Related Disorders

Edited by Alfred L. George, Jr. , Megan Abbott , Kevin J. Bender , Andreas Brunklaus , Scott Demarest , Shawn Egan , Isabel Haviland , Jennifer A. Kearney , Leah Schust Myers , Heather E. Olson , Stephan J. Sanders , Christina SanInocencio , Joseph S

ISBN 10: 1009530372 / ISBN 13: 9781009530378

Editore: Cambridge University Press, 2025

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Riassunto:

SCN2A encodes a voltage-gated sodium channel (designated NaV1.2) vital for generating neuronal action potentials. Pathogenic SCN2A variants are associated with a diverse array of neurodevelopmental disorders featuring neonatal or infantile onset epilepsy, developmental delay, autism, intellectual disability and movement disorders. SCN2A is a high confidence risk gene for autism spectrum disorder and a commonly discovered cause of neonatal onset epilepsy. This remarkable clinical heterogeneity is mirrored by extensive allelic heterogeneity and complex genotype-phenotype relationships partially explained by divergent functional consequences of pathogenic variants. Emerging therapeutic strategies targeted to specific patterns of NaV1.2 dysfunction offer hope to improving the lives of individuals affected by SCN2A-related disorders. This Element provides a review of the clinical features, genetic basis, pathophysiology, pharmacology and treatment of these genetic conditions authored by leading experts in the field and accompanied by perspectives shared by affected families. This title is also available as Open Access on Cambridge Core.

Dati bibliografici

Titolo: SCN2A-Related Disorders
Casa editrice: Cambridge University Press
Data di pubblicazione: 2025
Legatura: Paperback
Condizione: New
Edizione: Edizione Internazionale