Sigma Receptors

Rae R. Matsumoto

ISBN 10: 0387365125 / ISBN 13: 9780387365121

Editore: Springer US, Springer New York Nov 2006, 2006

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This item is printed on demand - Print on Demand Titel. Neuware -Over the last 30 years, our understanding of a receptors has undergone a colossal evolution. They began as theoretical entities, then progressed to enigmatic receptors, and finally to identified proteins with important biological functions. Since the first book on a receptors was published in 1994, there have been many significant advances in the field. We now know that o receptors subserve many critical functions in the body and recent studies indicate that they are promising drug development targets for a host of neurological, psychiatric, cardiovascular, ophthalmological, immunological, and gastrointestinal disorders. This book provides a timely update on the medicinal chemistry, cell biology, and clinical implications of a receptors. It puts the information in a historical perspective to help new comers to the field successfully navigate the confusing early history surrounding these proteins, and it provides a launching point from which future studies and research directions can easily be developed. The full impact of a receptors on biological function has yet to be determined. The existing gaps in our knowledge base offer untold opportunities for future research. It is our hope that the information contained in this book will stimulate new, exciting research on a receptors and ultimately lead to innovative insights into basic biological mechanisms and novel therapeutic advances.Springer Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 428 pp. Englisch.

Codice articolo 9780387365121

Dati bibliografici

• Titolo: Sigma Receptors
• Editore: Springer US, Springer New York Nov 2006
• Data di pubblicazione: 2006
• Lingua: Inglese
• ISBN 10: 0387365125
• ISBN 13: 9780387365121
• Rilegatura: Buch
• Condizione: Neu
• Dimensioni: 241 L x 160 A x 28 P (millimetri) 241 millimetri di larghezza per 160 millimetri di altezza per 28 millimetri di profondità
• Peso: 805 grammi

Descrizione articolo

Riassunto

This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. The information is put in a historical perspective. This provides a launching point from which future studies and research directions can easily be developed.

Dalla quarta di copertina

Sigma receptors are promising drug development targets for a host of neurological, psychiatric, oncological, immunological, cardiovascular, ophthalmological, and gastrointestinal disorders. They are structurally unique proteins that are distinct from classical G protein-coupled receptors, ionotropic receptors, or receptor tyrosine kinases. With two subtypes currently known, they modulate cell survival and excitability, and subserve many critical functions in the body. Endogenous ligands for these receptors are unknown, though current clues point to neurosteroids.

This book provides a timely update on the medicinal chemistry, cell biology, and clinical implications of sigma receptors. It puts the information in a historical perspective to help new comers to the field successfully navigate the confusing early history surrounding these proteins, and provides a launching point for the development of exciting, new research.

Sigma Receptors: Chemistry, Cell Biology and Clinical Implications will be a valuable tool for pharmacologists, medicinal chemists, cell biologists, molecular biologists, clinicians, and others interested in a concise, state-of-the-art overview of the sigma receptor field with a particular view towards novel therapeutic advances.