TOXICOLOGY AND RISK ASSESSMENT: PRINCIPLES, METHODS, AND APPLICATIONS

Introduces the fundamental principles and current concepts of toxicology and risk assessment--offering comprehensive discussions on clinical testing, risk assessment of chemicals and hazardous materials, the application of animal data to human health risk assessment, mathematical models, statistical approaches, environmental laws, information resources, and risk management.

General Toxicology

Principles and Highlights of Toxicology, Arthur Furst and Anna M. Fan
Carcinogenesis: Basic Principles, David B. Couch
Principles of Genetic Toxicology, Wai Nang Choy
Principles Underlying Developmental Toxicity, John M. DeSesso and Stephen B. Harris
Principles of Neurotoxicity, I.K. Ho and Anna M. Fan
Biology of the Immune System and Immunotoxicity, Kathleen Rodgers
Pharmacokinetics and Risk Assessment, Raghubir P. Sharma and Roger A. Coulombe, Jr.

Toxicological Testing

Acute, Subchronic, and Chronic Toxicity Testing, Ann de Peyster and Moira A. Sullivan
Carcinogenicity Testing Methods, J. A. Wisniewski
Genetic Toxicology Testing, Wai Nang Choy
The Design, Evaluation, and Interpretation of Developmental Toxicity Tests, John M. DeSesso, Stephen B. Harris, and Stella M. Swain
Neurotoxicity Testing, I.K. Ho and Anna M. Fan
Immunotoxicity Testing, Kathleen Rodgers

Basic Elements and Approaches in Risk Assessment

Cancer Risk Assessment: Historical Perspectives, Current Issues, and Future Directions, Susan F. Velazquez, Rita Schoeny, Vincent J. Cogliano, and Glenn E. Rice
Risk Assessment: Principles and Methodologies, Welford C. Roberts and Charles O. Abernathy
Medium-Specific and Multimedium Risk Assessment, Brian K. Davis and A. K. Klein
Noncancer Risk Assessment: Present and Emerging Issues, John L. Cicmanec, Michael L. Dourson, and Richard C. Hertzberg

Risk Assessment of Chemical Mixtures and Chemical Interactions

Predicting the Toxicological Consequences of Multiple Chemical Interactions, Edward H. Calabrese
Interaction: An Epidemiological Perspective for Risk Assessment, Kenneth A. Mundt and Carl M. Shy
The Median Effect Equation: A Useful Mathematical Model for Assessing Interaction of Carcinogens and Low-Dose Cancer Quantitative Risk Assessment, James Stewart and Edward J. Calabrese
Genetic Toxicology and Risk Assessment of Complex Environmental Mixtures, Virginia Stewart Houk and Michael D. Waters
The Effect of Combined Exposures of Chlorine, Copper, and Nitrite on Methemoglobin Formation in Red Blood Cells of Dorset Sheep, Cynthia J. Langlois, James A. Garreffi, Linda A. Baldwin, and Edward J. Calabrese

Models and Statistical Methods

Statistical Methods in Developmental Toxicity Risk Assessment, Yiliang Zhu and Karen Fung
Applications of Receptor-Binding Models in Toxicology, J. Denes, D. Blakey, D. Krewski, and J. R. Withey
Statistical Analysis of heritable Mutagenesis Data, Walter W. Piegorsch
Statistical Analysis of Long-Term Animal Cancer Studies, Gregg E. Dinse
Risk Assessment for Nonquantal Toxic Effects, James J. Chen, Ralph L. Kodell, and David W. Gaylor
Physiologically Based Pharmacokinetic Modeling of Phenanthrene, I. Chu and Lung-fa Ku
Biologically Based Cancer Modeling, E. Georg Luebeck and Suresh H. Moolgavkar

Use of Human Data and Animal to Human Data Extrapolation

Epidemiology: General Principles, Methodological Issues, and Applications to Environmental Toxicology, Richard G. Ames
Use of Epidemiological Data for Assessment of Low Levels of Lead as Neurotoxic and Developmental Toxicants, Jerry J. Zarriello
Issues in Data Extrapolation, Joseph P. Brown and Andrew G. Salmon
Metam: Animal Toxicology and Human Risk Assessment, Lubow Jowa
Effects of Chemical-Chemical Interactions on the Evaluation of Toxicity, Amy L. Yorks and Katherine S. Squibb

Risk Assessment: Statutory Requirements and Resource Needs

Environmental Laws and Risk Assessment, Denise D. Fort
Resource Agencies with Information on Toxic Substances, Health Effects, Hanafi Russell, Todd Miller, and Yi Y. Wang
Resources for Toxicology Risk Assessment, Po-Yung Lu and John S. Wassom
Electronic Resources for Toxicology and Environmental Health, Mary Ann Mahoney and Charleen Kubota

Risk Assessment and Risk Management

Role of Risk Assessment in Regulatory Decision Making for Biotechnology: EPA's Experience Under TSCA, Ellie F. Clark
Risk Assessment for Risk Management and Regulatory Decision Making at the U.S. Food and Drug Administration, P. Michael Bolger, Clark D. Carrington, and Sara Hale Henry
Comparative Risk: Adding Value to Science, Richard A. Minard, Jr.
The Use of Comparative Risk Judgments in Risk Management, Carl F. Cranor
Risk Assessment in Monitoring, Compliance, and Enforcement, Barton P. Simmons