Textbook of Drug Design and Discovery, Fourth Edition

ISBN 10: 1420063227 / ISBN 13: 9781420063226

Editore: CRC Press, 2009

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The book is complete and readable, with all pages and cover intact. Dust jacket, shrink wrap, or boxed set case may be missing. Pages may have light notes, highlighting, or minor water exposure, but nothing that affects readability. May be an ex-library copy and could include library markings or stickers.

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Dati bibliografici

• Titolo: Textbook of Drug Design and Discovery, Fourth Edition
• Editore: CRC Press
• Data di pubblicazione: 2009
• Lingua: Inglese
• ISBN 10: 1420063227
• ISBN 13: 9781420063226
• Rilegatura: Rilegato
• Edizione: quarta edizione
• Condizione: acceptable

Descrizione articolo

Riassunto

The molecular biological revolution and the mapping of the human genome continue to provide new challenges and opportunities for drug research and design. Future medicinal chemists and drug designers must have a firm background in a number of related scientific disciplines in order to understand the conversion of new insight into lead structures and subsequently into drug candidates. Classroom tested and student approved, Textbook of Drug Design and Discovery, Fourth Edition describes the manner in which medicinal chemists utilize the various fields upon which they draw and the specific strategies they employ to advance promising molecules into clinical use for the treatment of disease.

This text integrates a number of related scientific disciplines, including advanced synthetic chemistry, computational chemistry, biochemistry, structural biology, and molecular pharmacology, to provide current and comprehensive information on all aspects of drug design and discovery.

Extensively revised, new topics in the fourth edition include:

• Biostructure-based and ligand-based drug design
• Chemical biology
• Natural products
• Imaging
• Neurotransmitter transporters
• Opioid and cannabinoid receptors
• Hypnotics
• Neglected diseases
• Immunomodulating agents
• Antibiotics

The first part of the book covers general aspects, methods, and principles for drug design and discovery, and the second part covers specific targets and diseases. The text contains more than 300 color figures and 24 tables for rapid assimilation. Each chapter includes references for further study. Most chapters also provide the background and history needed to provide a context for students, as well as conclusions that summarize the points most relevant to emerging areas of research in drug design.

Informazioni sull?autore

Povl Krogsgaard-Larsen is a professor of medicinal chemistry in the Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, at the University of Copenhagen. Kristian Strømgaard is a professor of chemical biology in the Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, at the University of Copenhagen. Ulf Madsen is currently an associate dean in the Faculty of Pharmaceutical Sciences at the University of Copenhagen.