Tgf-beta Signaling: Methods and Protocols da Feng, Xin-hua (Editor): Brand New Hardcover (2015)

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394 pages. 10.25x7.25x1.25 inches. In Stock.

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Titolo: Tgf-beta Signaling: Methods and Protocols
Editore: Humana Pr Inc
Data di pubblicazione: 2015
Lingua: Inglese
ISBN 10: 1493929658
ISBN 13: 9781493929658
Rilegatura: Hardcover
Condizione: Brand New

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Riassunto

This volume details up-to-date information and attempts to take the reader into the exciting realm of TGF-� from the basic principles to the practical applications. Chapters provide basic introduction of TGF-� signaling from the cell surface to the nucleus, methods and techniques for the investigation of TGF-� signaling mechanism including receptors, Smads, intracellular kinases, microRNA, epigenetic regulation, post-translational regulations, non-Smad pathway; the physiological implications including those in cell cycle arrest, epithelial-mesenchymal transition, endothelial cells, adipogenesis, Th differentiation, stem cell, bone remodeling, ovary, zebrofish development, and frog animal capping; and the methodologies including metastasis imaging, 3D morphogenesis, membrane receptor quantification, conditional knockout, bone remodeling, kinase and phosphatase assays, BiFC interaction assays, and genome-wide siRNA screen. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, TGF-Beta Signaling: Methods and Protocols aims to ensure successful results in the further study of this vital field.

Dalla quarta di copertina

This volume details up-to-date information and attempts to take the reader into the exciting realm of TGF-� from the basic principles to the practical applications. Chapters provide basic introduction of TGF-� signaling from the cell surface to the nucleus, methods and techniques for the investigation of TGF-� signaling mechanism including receptors, Smads, intracellular kinases, microRNA, epigenetic regulation, post-translational regulations, non-Smad pathway; the physiological implications including those in cell cycle arrest, epithelial-mesenchymal transition, endothelial cells, adipogenesis, Th differentiation, stem cell, bone remodeling, ovary, zebrofish development, and frog animal capping; and the methodologies including metastasis imaging, 3D morphogenesis, membrane receptor quantification, conditional knockout, bone remodeling, kinase and phosphatase assays, BiFC interaction assays, and genome-wide siRNA screen. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, TGF-Beta Signaling: Methods and Protocols aims to ensure successful results in the further study of this vital field.

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