Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders

Lingua: inglese

Editore: National Academies Press, US, 2017

0309455138 / 9780309455138

Da: Rarewaves.com UK, London, Regno UnitoRarewaves.com UK

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Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most CNS drugs fail because of efficacy, and the core issue underlying these problems is a poor understanding of disease biology. Concern about the poor productivity in neuroscience drug development has gained intensity over the past decade, amplified by a retraction in investment from the pharmaceutical industry. This retreat by industry has been fueled by the high failure rate of compounds in advanced clinical trials for nervous system disorders. In response to the de-emphasis of CNS disorders in therapeutic development relative to other disease areas such as cancer, metabolism, and autoimmunity, the National Academies of Sciences, Engineering, and Medicine initiated a series of workshops in 2012 to address the challenges that have slowed drug development for nervous system disorders. Motivated by the notion that advances in genetics and other new technologies are beginning to bring forth new molecular targets and identify new biomarkers, the Academies hosted the third workshop in this series in September 2016.Participants discussed opportunities to accelerate early stages of drug development for nervous system disorders in the absence of animal models that reflect disease and predict efficacy. This publication summarizes the presentations and discussions from the workshop.…

Codice articolo LU-9780309455138

Titolo
Therapeutic Development in the Absence of Predictive Animal Models of Nervous System Disorders
Autore
Author Stated, No
Editore
National Academies Press, US
Anno di pubblicazione
2017
Condizione
New
Rilegatura
Paperback
Lingua
inglese
ISBN 10
0309455138
ISBN 13
9780309455138

Rarewaves.com UK

London, Regno Unito

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Venditore AbeBooks dal 11 giugno 2025

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