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Topical Drug Bioavailability, Bioequivalence, and Penetration

Editore: Springer, 1993
ISBN 10: 0306443678 / ISBN 13: 9780306443671
Usato / Hardcover / Quantità: 1
Da Book Deals (Lewiston, NY, U.S.A.)
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Titolo: Topical Drug Bioavailability, Bioequivalence...

Casa editrice: Springer

Data di pubblicazione: 1993

Legatura: Hardcover

Condizione libro: Used


This Book is in Good Condition. Clean Copy With Light Amount of Wear. 100% Guaranteed. Summary: Topical Drug Delivery: Percutaneous Absorption (R.C. Wester, H.I. Maibah). Transdermal Delivery Systems (G.W. Cleary). In vitro Methodology: Practical Considerations in Developing a Quality Control (In vitro release) Procedure for Dermatological Products (V.P. Shah, J.P. Skelly). Diffusion Cell Design (R.L. Bronaugh). In vivo Methodology: In vivo Topical Bioavailability and Skin Decontamination (R.C. Wester, H.I. Maibach). Grafted Skin and Skin Flaps (J.E. Riviere). Factors Influencing Percutaneous Transport: In vivo and In vitro Skin Uptake and Permeation Studies (C.R. Behl et al.). The Dose Response of Percutaneous Absorbtion (R.C. Wester, H.I. Maibach). Modelling and Correlations: Pharmacokinetic and Pharmacodynamic Modelling of Transdermal Products (S.K. Gupta et al.). Animal Models for Percutaeous Absorption (R.C. Wester, H.I. Maibach). 14 additional articles. Index. Codice inventario libreria ABE_book_usedgood_0306443678

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Riassunto: Topical drug delivery has become one ofthe most exciting and challenging areas of pharmaceutical research in the last decade. Topical drugs encompass both dermal and transdermal products, which are used for local and systemic effects, respectively. This volume succinctly discusses different aspects of dermal and transdermal drug delivery and represents the state of the art and science in mea­ suring percutaneous penetration and in determining biological relevance. The topics covered are of importance for both basic research and clinical applications, for example, cutaneous bioavailability and bioequivalence. Signif­ icant areas discussed include dermal and transdermal drug delivery, in vitro and in vivo methodology to assessbioavailability and bioequivalence oftopical drug products, in vitro and in vivo correlations, and pharmacokinetic and pharma­ codynamic modeling. Also covered are regulatory considerations for the drug approval process and requirements for all topical drug products. Many of the complex issuesinvolved in the evaluation of both innovator and generic products are identified and explained as well. This reference guide will be a useful basic working tool for investigators, and will be a valuable asset to all pharmaceutical scientists involved in the development of topical drug products.

Sinossi: This volume presents the state-of-the-art of measuring percutaneous penetration and determining biological relevance in dermal and transdermal drug delivery. Both in vivo and in vitro models and methods are discussed in detail to provide pharmaceutical drug developers with an invaluable guide and reference.

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Indirizzo: Lewiston, NY, U.S.A.

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