Toxicogenomics in Predictive Carcinogenicity (Issues in Toxicology, Volume 28)

Research over the past decade has demonstrated that TGx methods of various types can be used to discriminate modes of mutagenesis as a function of dose. TGx can quickly inform safety evaluation regarding potential mechanisms of conventional outcomes and can provide essential dose-response information. This can then be used to ascertain the sequence of key events in a putative mode of action as may apply in quantitative cancer risk assessment. With the increasing complexity of research in mode of action investigations it is important to gain a better understand of approaches to data integration and health risk assessment. Furthermore, it is essential to consider how novel test systems and newer methods and approaches may be used in future to gain a better understanding of mechanisms.

Toxicogenomics in Predictive Carcinogenicity describes toxicogenomics methods in predictive carcinogenicity testing, mode of action and safety evaluation, and cancer risk assessment. It illustrates these methods using case studies that have yielded significant new information on compounds and classes of compounds that have proven difficult to evaluate using conventional methods alone. This book additionally covers current and potential toxicogenomic research using stem cells as well as new bioinformatics methods for drug discovery and environmental toxicology.

This publication is an indispensable tool for postgraduates, academics and industrialists working in biochemistry, genomics, carcinogenesis, pathology, pharmaceuticals, food technology, bioinformatics, risk assessment and environmental toxicology.

Toxicogenomics in Predictive Carcinogenicity describes toxicogenomics methods in predictive carcinogenicity testing, mode of action and safety evaluation, and cancer risk assessment. It illustrates these methods using case studies that have yielded significant new information on compounds and classes of compounds that have proven difficult to evaluate using conventional methods alone. This book additionally covers current and potential toxicogenomic research using stem cells as well as new bioinformatics methods for drug discovery and environmental toxicology.The information is needed because it has not previously been available. With the increasing complexity of research in mode of action investigations it is important to gain a better understand of approaches to data integration and health risk assessment. Furthermore, it is essential to consider how novel test systems and newer methods and approaches may be used in future to gain a better understanding of mechanisms. The proposed publication will provide details of chemical case studies not available in previous volumes and will demonstrate how various data is assembled and integrated to arrive at an informed assessment of chemical safety and human health risk. It will be the most current volume which comprehensively covers the subject. This publication is an indispensable tool for postgraduates, academics and industrialists working in biochemistry, genomics, carcinogenesis, pathology, pharmaceuticals, food technology, bioinformatics, risk assessment and environmental toxicology.

Societies:

American Association for Cancer Research AACR (http://www.aacr.org/)

Environmental Mutagenesis and Genomics Society (http://www.emgs/org)

International Association of Environmental Mutagen Societies (http://www.iaems/org)

International Union of Toxicology (http://www.iutox.org/)

Society of Toxicology (http://www.toxicology.org/)

Journals for reviews:

Cancer Research

Mutation Research

Toxicology Research

Toxicology and Applied Pharmacology

Regulatory Toxicology and Pharmacology

Toxicology

Toxicology Letters

Critical Reviews in Toxicology

Archives of Toxicology

Pharmacology & Toxicology

Fundamental and Applied Toxicology

Toxicologic Pathology

Clinical Toxicology

Human and Experimental Toxicology

International Journal of Toxicology

Toxicology and Industrial Health

Drug and Chemical Toxicology

Drug safety

Journal of Toxicology

Toxicological Sciences

Websites:

American Association for Cancer Research AACR (http://www.aacr.org/)

Environmental Mutagenesis and Genomics Society (http://www.emgs/org)

International Association of Environmental Mutagen Societies (http://www.iaems/org)

International Union of Toxicology (http://www.iutox.org/)

Society of Toxicology (http://www.toxicology.org/)

Cross-promote with the textbook Fundamental Toxicology

This book describes toxicogenomics methods in predictive carcinogenicity testing, mode of action and safety evaluation, and cancer risk assessment. This publication is an indispensable tool for postgraduates, academics and industrialists working in biochemistry, genomics, carcinogenesis, pathology, pharmaceuticals, food technology, bioinformatics, risk assessment and environmental toxicology.

Dr Michael D. Waters is currently a Consultant with Integrated Laboratory Systems Inc. He is also an Adjunct Professor of Toxicology at the University of North Carolina at Chapel Hill and of Pharmacology and Toxicology at Duke University. He is Editor of Mutation Research - Reviews in Mutation Research. He has over 35 years of experience as a biochemist, genetic toxicologist, toxicogenomics and information scientist. Over the last 20 years Dr Waters has also worked extensively on database development; designing and conducting genotoxicity assays and chemoprevention studies in in vitro models; and studying genomics, clinical and toxicologic pathology.

Dr Russell S. Thomas is Director of the National Center for Computational Toxicology with the U.S. Environmental Protection Agency. Prior to this he was Director of the Institute for Chemical Safety Sciences at The Hamner Institutes for Health Sciences for over 10 years. Dr. Thomas also maintains an adjunct faculty appointment in the Division of Pharmacogenomics and Individualized Therapy at the University of North Carolina at Chapel Hill. Dr. Thomas has additionally been active in molecular biology and genomics research at the McArdle Cancer Research Laboratory at the University of Wisconsin.