Transgenic Mouse: Methods and Protocols (Methods in Molecular Biology, Vol. 209)

Holly T. Sklar,Marten H. Hofker,Jan Van Deursen,Marten H. (EDT) Hofker,Jan (EDT) Van Deursen

ISBN 10: 0896039153 / ISBN 13: 9780896039155

Editore: Humana Press, 2002

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Ex- library copy with stamps and stickers.

Codice articolo mon0003287946

Dati bibliografici

• Titolo: Transgenic Mouse: Methods and Protocols (Methods in Molecular Biology, Vol. 209)
• Editore: Humana Press
• Data di pubblicazione: 2002
• Lingua: Inglese
• ISBN 10: 0896039153
• ISBN 13: 9780896039155
• Rilegatura: hardcover
• Condizione: Good

Descrizione articolo

Riassunto

Marten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularlyfor generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented.

Dalla quarta di copertina

Genetically very similar to the human species, mice play an important role in biomedical research and have served as experimental models for a wide variety of pathologies, including cancer, cardiovascular diseases, and behavioral disorders. In Transgenic Mouse Methods and Protocols, Marten Hofker and Jan van Deursen have assembled a multidisciplinary collection of readily reproducible methods for working with mice, and particularly for generating mouse models that will enable us to better understand gene function. Described in step-by-step detail by highly experienced investigators, these proven techniques include new methods for conditional, induced knockout, and transgenic mice, as well as for working with mice in such important research areas as immunology, cancer, and atherosclerosis. Such alternative strategies as random mutagenesis and viral gene transduction for studying gene function in the mouse are also presented. Care is taken to make clear the details of the available approaches, as well as their limitations.
Up-to-date and highly practical, Transgenic Mouse Methods and Protocols demonstrates clearly for both novice and expert investigators how to make novel transgenic mouse models, and how to use them effectively to understand the role of gene function in human health and disease.