Riassunto
The idea that the immune system may play a role in protecting against malignant disease is not new. Since the earliest days of immunology research, scientists have sought to understand the mechanisms by which the host immune system might recognize cancer cells, and to manipulate these responses for therapeutic gain. It has become clear that the key to immune recognition of tumors lies in the relationship between cells in the microenvironment of the tumor itself. This volume provides a comprehensive collection of techniques for establishing tumor cell lines, testing their immunogenicity, and characterizing the major effector cells, leading to protocols for manipulating antibody and T-cell receptor structure, preparing cytokine-secreting tumor cells and testing the efficiency of these new agents in preventing tumor growth. Researchers in immunology as a whole in addition to those interested in cancer immunology will find this volume to be an invaluable practical resource.
Recensione
'The editors of this book should be congratulated for ensuring that their contributors maintained a common style of method presentation, from the simplest of procedures such as the removal of a tumour from a tumour-bearing animal, to the more complex, such as modifying chimeric T-cells using chimeric T-cell receptor (TCR)-Ig genes. The instructions for each method are concise, precise and include a list of the equipment required for each procedure. In addition, methods for evaluating the success of a procedure are detailed carefully, so thst the practitioner can evaluate if a technique has been accomplished successfully ... the methods and protocols described within this volume will be extremely useful for the basic tumour immunobiologist, regardless of theirlevel of experience.'Lionel A. Manson, University of Pennsylvania, Immunology Today, Vol. 15, No. 2, 1994
This book provides a comprehensive discussion of the many techniques and approaches essential for the study of tumor immunobiology. Each chapter provides excellent background information to clarify the importance of the technique, approach, or antitumor mechanism which is being discussed. I would strongly recommend this text as a reference for individuals working in tumor immunology as well as for the scientist interested in understanding practical techniques needed to evaluate the immune response to cancer. This book clearly encourages and facilitates additional research in tumor immunology by providing essential tools for investigators interested in this research. (M. Albertini, Oncology, Vol. 52, No. 3, 1995)
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