pKa Prediction for Organic Acids and Bases

D. Perrin

ISBN 10: 9400958854 / ISBN 13: 9789400958852

Editore: Springer, Springer Nov 2012, 2012

Riguardo questo articolo

Neuware -Many chemists and biochemists require to know the ionization constants of organic acids and bases. This is evident from the Science Citation Index which lists The Determination of Ionization Constants by A. Albert and E. P. Serjeant (1971) as one of the most widely quoted books in the chemical literature. Although, ultimately, there is no satisfactory alternative to experimental measurement, it is not always convenient or practicable to make the necessary measure ments and calculations. Moreover, the massive pK. compilations currently available provide values for only a small fraction of known or possible acids or bases. For example, the compilations listed in Section 1. 3 give pK. data for some 6 000--8 000 acids, whereas if the conservative estimate is made that there are one hundred different substituent groups available to substitute in the benzene ring of benzoic acid, approximately five million tri-substituted benzoic acids are theoretically possible. Thus we have long felt that it is useful to consider methods by which a pK. value might be predicted as an interim value to within several tenths of a pH unit using arguments based on linear free energy relationships, by analogy, by extrapolation, by interpolation from existing data, or in some other way. This degree of precision may be adequate for many purposes such as the recording of spectra of pure species (as anion, neutral molecule or cation), for selection of conditions favourable to solvent extraction, and for the interpretation of pH-profiles for organic reactions.

Codice articolo 9789400958852

Dati bibliografici

• Titolo: pKa Prediction for Organic Acids and Bases
• Editore: Springer, Springer Nov 2012
• Data di pubblicazione: 2012
• Lingua: Inglese
• ISBN 10: 9400958854
• ISBN 13: 9789400958852
• Rilegatura: Taschenbuch
• Condizione: Neu
• Dimensioni: 216 L x 140 A x 9 P (millimetri) 216 millimetri di larghezza per 140 millimetri di altezza per 9 millimetri di profondità
• Peso: 211 grammi

Descrizione articolo

Riassunto

Many chemists and biochemists require to know the ionization constants of organic acids and bases. This is evident from the Science Citation Index which lists The Determination of Ionization Constants by A. Albert and E. P. Serjeant (1971) as one of the most widely quoted books in the chemical literature. Although, ultimately, there is no satisfactory alternative to experimental measurement, it is not always convenient or practicable to make the necessary measure­ ments and calculations. Moreover, the massive pK. compilations currently available provide values for only a small fraction of known or possible acids or bases. For example, the compilations listed in Section 1. 3 give pK. data for some 6 000--8 000 acids, whereas if the conservative estimate is made that there are one hundred different substituent groups available to substitute in the benzene ring of benzoic acid, approximately five million tri-substituted benzoic acids are theoretically possible. Thus we have long felt that it is useful to consider methods by which a pK. value might be predicted as an interim value to within several tenths of a pH unit using arguments based on linear free energy relationships, by analogy, by extrapolation, by interpolation from existing data, or in some other way. This degree of precision may be adequate for many purposes such as the recording of spectra of pure species (as anion, neutral molecule or cation), for selection of conditions favourable to solvent extraction, and for the interpretation of pH-profiles for organic reactions.

Contenuti

1 Introduction.- 2 Molecular factors that modify pKa values.- 3 Methods of pKa prediction.- 4 Prediction of pKa values of substituted aliphatic acids and bases.- 5 Prediction of pKa values for phenols, aromatic carboxylic acids and aromatic amines.- 6 Further applications of Hammett and Taft equations.- 7 Some more difficult cases.- 8 Extension of the Hammett and Taft equations.- 9 Examples where prediction presents difficulties.- 10 Recapitulation of the main pKa prediction methods.- A.1 Substituent constants for the Hammett and Taft equations.- A.4 Special sigma constants for para substituents.- A.6 Sigma constants for heteroatoms in heterocyclic rings.- References.