Bioinformatics Basics : Applications in the Biological Sciences and Medicine

Buehler, Lukas K., Rashidi, Hooman H.

ISBN 10: 0849323754 / ISBN 13: 9780849323751

Editore: CRC Press LLC, 1999

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Ships from the UK. Former library book; may include library markings. Used book that is in clean, average condition without any missing pages.

Codice articolo GRP102781353

Dati bibliografici

• Titolo: Bioinformatics Basics : Applications in the Biological Sciences and Medicine
• Editore: CRC Press LLC
• Data di pubblicazione: 1999
• Lingua: Inglese
• ISBN 10: 0849323754
• ISBN 13: 9780849323751
• Rilegatura: Rilegato
• Edizione: 1st Edition.
• Condizione: Good

Descrizione articolo

Riassunto

Scientists in the throes of research use an extensive data bank to access structural information on proteins and nucleic acids. Meanwhile, geneticists use a highly specialized form of software to analyze the hybridization pattern of DNA chips. The past decade has been tremendously successful for biotechnology and pharmaceutical industries. This success has been a result of astounding technical advancements in genome sequencing (genomics), protein identification (proteomics), and data analysis-collectively called bioinformatics. The exponential increase in computer processing and disk storage has served as a catalyst and been instrumental in the development of bioinformatics. Bioinformatics Basics: Applications in Biological Science and Medicine describes the origin of this field and the organization of public domain databases with an introductory tutorial for the services described. This book explains these services in a relatively simple fashion. Nevertheless, a biological background is necessary to understand and properly utilize the various software components and services described in this book. A basic biological background is also necessary for understanding the biological and medical significance of the collected data. Bioinformatics Basics is a fast growing field, and it will take some years for a stabilization to occur. Until then, hundreds of Internet sites allow us to search, compare, and manipulate this data in its relatively raw format. Bioinformatics Basics: Applications in Biological Science and Medicine concentrates on three major database clusters and relevant software tools that are maintained in the United States, Europe, and Japan, offering free access and analysis through the Internet.

Contenuti

INTRODUCTION
Biology and Bioinformatics
The Nature of Publicly Funded Research
Genomics and Proteomics
Metabolic Databases
Public and Proprietary Bioinformatics
Computers in Biology and Medicine
Computer Algorithms
Super Computers
Limitations of Computational Tools - Paradoxical Promise of the Internet
The Need For Computational Tools
New Approaches to Scientific Research With Computers
Biological Macromolecules
Proteins
Protein Structure
Protein Folding
Protein Function
DNA and RNA Structure
Nucleic Acid Structure and Function
Genetic Code
DATABASES AND SEARCH TOOLS
Computational Tools and Databases
National Center for Biotechnology Information (NCBI)
European Bioinformatics Institute (EBI)
Genome Net - Japanese Bioinformatics Servers
Database Mining Tools
Sequence Similarity Search Tools: BLAST
Pattern Recognition Tools and Databases
GENOME ANALYSIS
DNA Cloning and PCR
DNA Cloning
Transcriptional Profiling
Positional Cloning
Polymer Chain Reaction PCR
Technologies Under Development
Monitoring Sequencing Progress
Computational Tools for DNA Sequence Analysis
Database Sequence Submission
Data Retrieval
Sequence Alignment
Biological Function of Sequences - Annotation
Identifying ORFs and URFs
Redundancy in Sequence Data
Better Search Engines for Better Computers?
Genome Analysis
The Genome Organization
Mapping the Genome
Human Genome Mapping Progress
Functional Genomics
Unidentified Reading Frames
Cluster of Orthologous Groups
PROTEOME ANALYSIS
Proteomics
2D Page at Expasy
Yeast Proteome Database
Metabolic Reconstruction
KEGG: Kyoto Encyclopedia of Genes and Genomes
The Functional Reconstruction Model
E.coli Metabolic Database - EcoCyc
Where should we be in the future?
COMPUTER REVOLUTION IN NEUROBIOLOGY
Human Brain Project
The Influence of Computers in Science
Computers in Neurobiology and the Mapping of the Human Brain
From Molecules to Neurodegenerative Diseases
Computer Simulations and Visualization of Molecular Structures
Computer Simulations and Visualization of Molecular Structures
Predictive Biology
Protein Structure Prediction
Structure Prediction Software
APPENDIX