Microarrays for an Integrative Genomics (Computational Molecular Biology) (Computational Molecular Biology Series)

Kohane, Isaac S.; Kho, Alvin; Butte, Atul J.

ISBN 10: 026211271X / ISBN 13: 9780262112710

Editore: Bradford Books, 2002

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Titolo: Microarrays for an Integrative Genomics (...

Casa editrice: Bradford Books

Data di pubblicazione: 2002

Legatura: hardcover

Condizione: Very Good

Condizione sovraccoperta: sovraccoperta

Edizione: 1st Edition.

Descrizione articolo

Riassunto:

Functional genomics--the deconstruction of the genome to determine the biologicalfunction of genes and gene interactions--is one of the most fruitful new areas of biology. Thegrowing use of DNA microarrays allows researchers to assess the expression of tens of thousands ofgenes at a time. This quantitative change has led to qualitative progress in our ability tounderstand regulatory processes at the cellular level.This book provides a systematic introductionto the use of DNA microarrays as an investigative tool for functional genomics. The presentation isappropriate for readers from biology or bioinformatics. After presenting a framework for the designof microarray-driven functional genomics experiments, the book discusses the foundations foranalyzing microarray data sets, genomic data-mining, the creation of standardized nomenclature anddata models, clinical applications of functional genomics research, and the future of functionalgenomics.

L'autore:

Isaac S. Kohane is Director of the Children's Hospital Informatics Program, Associate Professor of Pediatrics at Harvard Medical School, and an Attending Physician in Endocrinology at Children's Hospital, Boston.