Structure-Function Analysis of G Protein-Coupled Receptors (Hardcover)

Juergen Wess

ISBN 10: 047125228X / ISBN 13: 9780471252283

Editore: John Wiley & Sons Inc, New York, 1999

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Hardcover. G protein-coupled receptors (GPCRs) are the largest single class of receptors in biology, often playing key roles in a remarkably large number of physiological and pathophysiological conditions. GPCRs or GPCR-dependent signalling pathways are the targets of a very large number of therapeutically useful drugs. Detailed knowledge about the molecular structure of GPCRs should therefore pave the way for the design of novel drugs with increased efficacy and specificity. This volume provides a concise, up-to-date presentation of methods (including molecular genetic, biochemical, and biophysical) which have been used successfully in studying the structure and function of GPCRs. With contributions from international leaders in the field, the editor provides overviews of various techniques, followed by in-depth descriptions of basic procedures and discussions of critical experimental parameters. Divided into specific, accessible sections, Structure-Function Analysis of G Protein-Coupled Receptors includes: * An overview of mutagenesis techniques * Examples of molecular modeling techniques * Using peptides as tools for the study of GPCR interactions * Site-Directed Spin Labeling (SDSL) studies of the GPCR rhodopsin * A complete description of the electron-crystalographic analysis of two-dimensional rhodopsin crystals * The use of nuclear magnetic resonance techniques to study GPCR structure This presentation of methods (including molecular genetic, biochemical, and biophysical) is useful for studying the structure and function of G protein-coupled receptors (GPCRs). It focuses on methodology, but also includes techniques that can be used by readers at the laboratory bench. Shipping may be from our Sydney, NSW warehouse or from our UK or US warehouse, depending on stock availability.

Codice articolo 9780471252283

Dati bibliografici

• Titolo: Structure-Function Analysis of G Protein-Coupled Receptors (Hardcover)
• Editore: John Wiley & Sons Inc, New York
• Data di pubblicazione: 1999
• Lingua: Inglese
• ISBN 10: 047125228X
• ISBN 13: 9780471252283
• Rilegatura: Hardcover
• Edizione: prima edizione
• Condizione: new

Descrizione articolo

Riassunto

G protein-coupled receptors (GPCRs) are the largest single class of receptors in biology, often playing key roles in a remarkably large number of physiological and pathophysiological conditions. GPCRs or GPCR-dependent signalling pathways are the targets of a very large number of therapeutically useful drugs. Detailed knowledge about the molecular structure of GPCRs should therefore pave the way for the design of novel drugs with increased efficacy and specificity.

This volume provides a concise, up-to-date presentation of methods (including molecular genetic, biochemical, and biophysical) which have been used successfully in studying the structure and function of GPCRs. With contributions from international leaders in the field, the editor provides overviews of various techniques, followed by in-depth descriptions of basic procedures and discussions of critical experimental parameters.

Divided into specific, accessible sections, Structure-Function Analysis of G Protein-Coupled Receptors includes:
* An overview of mutagenesis techniques
* Examples of molecular modeling techniques
* Using peptides as tools for the study of GPCR interactions
* Site-Directed Spin Labeling (SDSL) studies of the GPCR rhodopsin
* A complete description of the electron-crystalographic analysis of two-dimensional rhodopsin crystals
* The use of nuclear magnetic resonance techniques to study GPCR structure

Informazioni sull?autore

Jürgen Wess is the author of Structure-Function Analysis of G Protein-Coupled Receptors, published by Wiley.