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ISBN 10: 3659565474 ISBN 13: 9783659565472
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ISBN 10: 3659565474 ISBN 13: 9783659565472
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Editore: LAP LAMBERT Academic Publishing Nov 2014, 2014
ISBN 10: 3659639699 ISBN 13: 9783659639692
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Aggiungi al carrelloTaschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Salbutamol sulfate (SS), a direct acting sympathomimetic; used for the treatment of acute and chronic asthma, was formulated as gelerite® in-situ gels. SS in-situ gels (2% w/w) were prepared at concentration of gellan gum 0.2%, 0.4% and 0.8% w/v with methyl paraben (0.05%) as preservative. In-vitro release in simulated nasal fluid showed relatively fast release and release kinetics followed diffusion kinetic model. In-vivo mucoadhesiveness test performed in rats, showed prolonged mucociliary transport time from 5 min (control solution) to 16.5 and 19.5 minutes for formulations containing 0.4% & 0.8% respectively. In-situ gels have demonstrated an adequate safety to the nasal mucosa of rats. The 0.4 % in-situ gel remained liquid for 6 months without occurrence of turbidity or gelation at storage temperature conditions. Statistical analysis revealed non-significant difference in content uniformity or release compared to the fresh ones. In-situ gel is a promising approach for the intranasal delivery of SS, combines the advantage of a solution , administration convenience and exact dosing with favorable residence time and expected improved drug absorption. . 68 pp. Englisch.
Lingua: Inglese
Editore: LAP LAMBERT Academic Publishing, 2014
ISBN 10: 3659639699 ISBN 13: 9783659639692
Da: moluna, Greven, Germania
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Aggiungi al carrelloCondizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Farid Mansour RagwaRagwa Farid MansourPh-D Lecturer of Pharmaceutical Sciences, Department of PharmaceuticsFaculty of Pharmacy & Drug Manufacturing, Pharos University in AlexandriaThe authors have published many publications in diffe.
Lingua: Inglese
Editore: LAP LAMBERT Academic Publishing, 2014
ISBN 10: 3659565474 ISBN 13: 9783659565472
Da: moluna, Greven, Germania
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Aggiungi al carrelloCondizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Gaafar PassentPassent Gaafar obtained her master degree in Pharmaceutics in December 2013. Further she is working as teacher assistant in faculty of pharmacy and drug manufacturing , Pharos university, Egypt. In present she is workin.
Lingua: Inglese
Editore: LAP LAMBERT Academic Publishing, 2014
ISBN 10: 3659639699 ISBN 13: 9783659639692
Da: AHA-BUCH GmbH, Einbeck, Germania
EUR 39,90
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Aggiungi al carrelloTaschenbuch. Condizione: Neu. nach der Bestellung gedruckt Neuware - Printed after ordering - Salbutamol sulfate (SS), a direct acting sympathomimetic; used for the treatment of acute and chronic asthma, was formulated as gelerite® in-situ gels. SS in-situ gels (2% w/w) were prepared at concentration of gellan gum 0.2%, 0.4% and 0.8% w/v with methyl paraben (0.05%) as preservative. In-vitro release in simulated nasal fluid showed relatively fast release and release kinetics followed diffusion kinetic model. In-vivo mucoadhesiveness test performed in rats, showed prolonged mucociliary transport time from 5 min (control solution) to 16.5 and 19.5 minutes for formulations containing 0.4% & 0.8% respectively. In-situ gels have demonstrated an adequate safety to the nasal mucosa of rats. The 0.4 % in-situ gel remained liquid for 6 months without occurrence of turbidity or gelation at storage temperature conditions. Statistical analysis revealed non-significant difference in content uniformity or release compared to the fresh ones. In-situ gel is a promising approach for the intranasal delivery of SS, combines the advantage of a solution , administration convenience and exact dosing with favorable residence time and expected improved drug absorption. .
Lingua: Inglese
Editore: LAP LAMBERT Academic Publishing Nov 2014, 2014
ISBN 10: 3659639699 ISBN 13: 9783659639692
Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germania
EUR 39,90
Quantità: 1 disponibili
Aggiungi al carrelloTaschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Salbutamol sulfate (SS), a direct acting sympathomimetic; used for the treatment of acute and chronic asthma, was formulated as gelerite® in-situ gels. SS in-situ gels (2% w/w) were prepared at concentration of gellan gum 0.2%, 0.4% and 0.8% w/v with methyl paraben (0.05%) as preservative. In-vitro release in simulated nasal fluid showed relatively fast release and release kinetics followed diffusion kinetic model. In-vivo mucoadhesiveness test performed in rats, showed prolonged mucociliary transport time from 5 min (control solution) to 16.5 and 19.5 minutes for formulations containing 0.4% & 0.8% respectively. In-situ gels have demonstrated an adequate safety to the nasal mucosa of rats. The 0.4 % in-situ gel remained liquid for 6 months without occurrence of turbidity or gelation at storage temperature conditions. Statistical analysis revealed non-significant difference in content uniformity or release compared to the fresh ones. In-situ gel is a promising approach for the intranasal delivery of SS, combines the advantage of a solution , administration convenience and exact dosing with favorable residence time and expected improved drug absorption. .Books on Demand GmbH, Überseering 33, 22297 Hamburg 68 pp. Englisch.