Da: California Books, Miami, FL, U.S.A.
EUR 69,90
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Aggiungi al carrelloCondizione: New.
Lingua: Inglese
Editore: LAP LAMBERT Academic Publishing, 2016
ISBN 10: 3659954926 ISBN 13: 9783659954924
Da: Revaluation Books, Exeter, Regno Unito
EUR 106,58
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Aggiungi al carrelloPaperback. Condizione: Brand New. 196 pages. 8.66x5.91x0.45 inches. In Stock.
Lingua: Inglese
Editore: LAP LAMBERT Academic Publishing Okt 2016, 2016
ISBN 10: 3659954926 ISBN 13: 9783659954924
Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germania
EUR 64,90
Quantità: 2 disponibili
Aggiungi al carrelloTaschenbuch. Condizione: Neu. Neuware -Thyroid carcinoma is the most prevalent endocrine malignancy and accounts for 2% of all human cancers. We screened exon 15 of BRAF gene; exons 1 and 2 of RAS genes in sixty (60) consecutive thyroid tissue (tumor and adjacent normal) samples. Overall mutations in BRAF was found to be 25% (15 of 60)affecting codon 600 (valine to glutamine) and restricted only to papillary thyroid cancer but devoid of any RAS mutation. We screened 140 blood samples from thyroid cancer patients for HRAS T81C and RET polymorphism in comparison with 170 cancer-free controls. TSHR gene was found to be hyper methylated in 25 % (15 of 60) of the cases with strong association with elevated TSH levels. We conclude that both mutational events as well as over-expression of BRAF gene is highly implicated in pathogenesis of thyroid cancer and the BRAF protein overexpression is independent of the BRAF mutational status. HRAS T81C and RET polymorphisms moderately increases thyroid cancer risk. Our study showed a high implication of TSHR gene methylation and its signi¿cant association with BRAF V600E mutation in thyroid tumors, depicting a positive connection between TSHR pathway and MAP Kinase pathway.Books on Demand GmbH, Überseering 33, 22297 Hamburg 196 pp. Englisch.
Lingua: Inglese
Editore: LAP LAMBERT Academic Publishing, 2016
ISBN 10: 3659954926 ISBN 13: 9783659954924
Da: preigu, Osnabrück, Germania
EUR 55,55
Quantità: 5 disponibili
Aggiungi al carrelloTaschenbuch. Condizione: Neu. Genetic Alterations in Thyroid Cancer Patients of Kashmir Valley | Race against Thyroid Cancer | Mosin S. Khan (u. a.) | Taschenbuch | 196 S. | Englisch | 2016 | LAP LAMBERT Academic Publishing | EAN 9783659954924 | Verantwortliche Person für die EU: BoD - Books on Demand, In de Tarpen 42, 22848 Norderstedt, info[at]bod[dot]de | Anbieter: preigu.
Da: PBShop.store US, Wood Dale, IL, U.S.A.
EUR 76,15
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Aggiungi al carrelloPAP. Condizione: New. New Book. Shipped from UK. Established seller since 2000.
Da: PBShop.store UK, Fairford, GLOS, Regno Unito
EUR 72,30
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Aggiungi al carrelloPAP. Condizione: New. New Book. Shipped from UK. Established seller since 2000.
Lingua: Inglese
Editore: Springer Nature Singapore, Springer Nature Singapore, 2025
ISBN 10: 9819627621 ISBN 13: 9789819627622
Da: AHA-BUCH GmbH, Einbeck, Germania
EUR 306,16
Quantità: 1 disponibili
Aggiungi al carrelloBuch. Condizione: Neu. Druck auf Anfrage Neuware - Printed after ordering - This book discusses different signaling pathways involved in tumor development and progression. It discusses the pathways that allow tumor cells to proliferate, survive, and invade other tissues. Further, the book reviews the signal transduction regulating phagocytosis, production of cytokines, cell division, and differentiation. It elucidates the dysregulation of cellular signal transduction induced by the genetic and epigenetic changes that drive cancer and enumerates the signaling network encompassing the extracellular matrix, blood vessels, and the immune system. Additionally, the book provides mechanistic insights into inhibitors of the receptor tyrosine kinases, BRAF, EGFR, and ALK that improve clinical response and increase the survival of patients with cancer. The book covers the signal transduction pathways that regulate cell cycle progression and genomic stability, providing a mechanistic understanding of the major checkpoint pathways, and reviewing their diagnostic and therapeutic potential. This volume is essential reading for researchers to understand the therapeutic potential of important signaling molecules against cancer.
Da: Books Puddle, New York, NY, U.S.A.
Condizione: New.
Lingua: Portoghese
Editore: Edições Nosso Conhecimento, 2025
ISBN 10: 6208922003 ISBN 13: 9786208922009
Da: California Books, Miami, FL, U.S.A.
EUR 69,90
Quantità: Più di 20 disponibili
Aggiungi al carrelloCondizione: New.
Da: California Books, Miami, FL, U.S.A.
EUR 69,90
Quantità: Più di 20 disponibili
Aggiungi al carrelloCondizione: New.
Da: California Books, Miami, FL, U.S.A.
EUR 69,90
Quantità: Più di 20 disponibili
Aggiungi al carrelloCondizione: New.
Da: California Books, Miami, FL, U.S.A.
EUR 69,90
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Aggiungi al carrelloCondizione: New.
Condizione: New.
Lingua: Portoghese
Editore: Edi??es Nosso Conhecimento, 2025
ISBN 10: 6208922003 ISBN 13: 9786208922009
Da: PBShop.store US, Wood Dale, IL, U.S.A.
EUR 76,11
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Aggiungi al carrelloPAP. Condizione: New. New Book. Shipped from UK. Established seller since 2000.
Da: PBShop.store US, Wood Dale, IL, U.S.A.
EUR 76,13
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Aggiungi al carrelloPAP. Condizione: New. New Book. Shipped from UK. Established seller since 2000.
Da: PBShop.store US, Wood Dale, IL, U.S.A.
EUR 76,13
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Aggiungi al carrelloPAP. Condizione: New. New Book. Shipped from UK. Established seller since 2000.
Da: PBShop.store US, Wood Dale, IL, U.S.A.
EUR 76,15
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Aggiungi al carrelloPAP. Condizione: New. New Book. Shipped from UK. Established seller since 2000.
Lingua: Portoghese
Editore: Edi??es Nosso Conhecimento, 2025
ISBN 10: 6208922003 ISBN 13: 9786208922009
Da: PBShop.store UK, Fairford, GLOS, Regno Unito
EUR 72,30
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Aggiungi al carrelloPAP. Condizione: New. New Book. Shipped from UK. Established seller since 2000.
Da: PBShop.store UK, Fairford, GLOS, Regno Unito
EUR 72,30
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Aggiungi al carrelloPAP. Condizione: New. New Book. Shipped from UK. Established seller since 2000.
Da: PBShop.store UK, Fairford, GLOS, Regno Unito
EUR 72,30
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Aggiungi al carrelloPAP. Condizione: New. New Book. Shipped from UK. Established seller since 2000.
Da: PBShop.store UK, Fairford, GLOS, Regno Unito
EUR 72,30
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Aggiungi al carrelloPAP. Condizione: New. New Book. Shipped from UK. Established seller since 2000.
Lingua: Portoghese
Editore: Edições Nosso Conhecimento, 2025
ISBN 10: 6208922003 ISBN 13: 9786208922009
Da: Books Puddle, New York, NY, U.S.A.
Condizione: New.
Da: Books Puddle, New York, NY, U.S.A.
Condizione: New.
Condizione: New.
Lingua: Portoghese
Editore: Edições Nosso Conhecimento, 2025
ISBN 10: 6208922003 ISBN 13: 9786208922009
Da: preigu, Osnabrück, Germania
EUR 55,55
Quantità: 5 disponibili
Aggiungi al carrelloTaschenbuch. Condizione: Neu. Alterações genéticas em pacientes com cancro da tiróide do Vale da Caxemira | Corrida contra o cancro da tiróide | Mosin S. Khan (u. a.) | Taschenbuch | Portugiesisch | 2025 | Edições Nosso Conhecimento | EAN 9786208922009 | Verantwortliche Person für die EU: preigu GmbH & Co. KG, Lengericher Landstr. 19, 49078 Osnabrück, mail[at]preigu[dot]de | Anbieter: preigu.
Da: Buchpark, Trebbin, Germania
EUR 44,03
Quantità: 2 disponibili
Aggiungi al carrelloCondizione: Hervorragend. Zustand: Hervorragend | Sprache: Deutsch | Produktart: Bücher | Das Schilddrüsenkarzinom ist das häufigste endokrine Malignom und macht 2 % aller menschlichen Krebserkrankungen aus. Wir untersuchten Exon 15 des BRAF-Gens sowie Exon 1 und 2 des RAS-Gens in sechzig (60) konsekutiven Schilddrüsengewebeproben (Tumor und angrenzende normale Gewebe). Es wurde festgestellt, dass insgesamt 25 % (15 von 60) der BRAF-Mutationen das Codon 600 (Valin zu Glutamin) betreffen und nur bei papillärem Schilddrüsenkrebs vorkommen, aber keine RAS-Mutation aufweisen. Wir untersuchten 140 Blutproben von Schilddrüsenkrebspatienten auf HRAS T81C und RET-Polymorphismus im Vergleich zu 170 krebsfreien Kontrollen. In 25 % (15 von 60) der Fälle wurde eine Hypermethylierung des TSHR-Gens festgestellt, die in engem Zusammenhang mit erhöhten TSH-Werten steht. Wir kommen zu dem Schluss, dass sowohl Mutationsereignisse als auch die Überexpression des BRAF-Gens in hohem Maße an der Pathogenese von Schilddrüsenkrebs beteiligt sind und dass die Überexpression des BRAF-Proteins unabhängig vom BRAF-Mutationsstatus ist. HRAS T81C und RET-Polymorphismen erhöhen das Schilddrüsenkrebsrisiko mäßig. Unsere Studie zeigte eine hohe Bedeutung der TSHR-Genmethylierung und ihre signifikante Assoziation mit der BRAF V600E-Mutation bei Schilddrüsentumoren, was auf eine positive Verbindung zwischen dem TSHR-Signalweg und dem MAP-Kinase-Signalweg hinweist.
Lingua: Inglese
Editore: LAP LAMBERT Academic Publishing Okt 2016, 2016
ISBN 10: 3659954926 ISBN 13: 9783659954924
Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania
EUR 64,90
Quantità: 2 disponibili
Aggiungi al carrelloTaschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Thyroid carcinoma is the most prevalent endocrine malignancy and accounts for 2% of all human cancers. We screened exon 15 of BRAF gene; exons 1 and 2 of RAS genes in sixty (60) consecutive thyroid tissue (tumor and adjacent normal) samples. Overall mutations in BRAF was found to be 25% (15 of 60) affecting codon 600 (valine to glutamine) and restricted only to papillary thyroid cancer but devoid of any RAS mutation. We screened 140 blood samples from thyroid cancer patients for HRAS T81C and RET polymorphism in comparison with 170 cancer-free controls. TSHR gene was found to be hyper methylated in 25 % (15 of 60) of the cases with strong association with elevated TSH levels. We conclude that both mutational events as well as over-expression of BRAF gene is highly implicated in pathogenesis of thyroid cancer and the BRAF protein overexpression is independent of the BRAF mutational status. HRAS T81C and RET polymorphisms moderately increases thyroid cancer risk. Our study showed a high implication of TSHR gene methylation and its signi cant association with BRAF V600E mutation in thyroid tumors, depicting a positive connection between TSHR pathway and MAP Kinase pathway. 196 pp. Englisch.
Lingua: Inglese
Editore: LAP LAMBERT Academic Publishing, 2016
ISBN 10: 3659954926 ISBN 13: 9783659954924
Da: moluna, Greven, Germania
EUR 52,90
Quantità: Più di 20 disponibili
Aggiungi al carrelloCondizione: New. Dieser Artikel ist ein Print on Demand Artikel und wird nach Ihrer Bestellung fuer Sie gedruckt. Autor/Autorin: Khan Mosin S.Dr. Mosin Saleem Khan (born, 17.11.1985) was conferred Ph.D (Biochemistry and Molecular biology) from Sher-I-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar. Dr. Mosin is the recipient of University Gold M.
Paperback. Condizione: new. Paperback. Le carcinome thyroidien est la tumeur maligne endocrinienne la plus repandue et represente 2 % de tous les cancers humains. Nous avons analyse l'exon 15 du gene BRAF et les exons 1 et 2 des genes RAS dans soixante (60) echantillons consecutifs de tissu thyroidien (tumeur et tissus normaux adjacents). Les mutations globales de BRAF se sont revelees etre 25% (15 sur 60) affectant le codon 600 (valine a glutamine) et limitees uniquement au cancer papillaire de la thyroide, mais depourvues de toute mutation de RAS. Nous avons analyse 140 echantillons de sang de patients atteints de cancer de la thyroide a la recherche du polymorphisme HRAS T81C et RET, en comparaison avec 170 temoins exempts de cancer. Le gene TSHR s'est revele hypermethyle dans 25 % (15 sur 60) des cas, avec une forte association avec des niveaux eleves de TSH. Nous concluons que les evenements mutationnels ainsi que la surexpression du gene BRAF sont fortement impliques dans la pathogenese du cancer de la thyroide et que la surexpression de la proteine BRAF est independante du statut mutationnel de BRAF. Les polymorphismes HRAS T81C et RET augmentent moderement le risque de cancer de la thyroide. Notre etude a montre une forte implication de la methylation du gene TSHR et son association significative avec la mutation BRAF V600E dans les tumeurs thyroidiennes, decrivant une connexion positive entre la voie TSHR et la voie MAP Kinase. This item is printed on demand. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.
Lingua: Spagnolo
Editore: Ediciones Nuestro Conocimiento Mai 2025, 2025
ISBN 10: 6208921988 ISBN 13: 9786208921989
Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania
EUR 64,90
Quantità: 2 disponibili
Aggiungi al carrelloTaschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 196 pp. Spanisch.