p j ohanlon (1 risultati)

Hardcover. Condizione: Near Fine. 0854047077. Pictorial board hardcover, from closed pharmaceutical company library. Lending record shows this book has been borrowed once only. 350 pages, index, illustrated with charts, tables and diagrams. Discusses advances in the chemistry of antibacterials/antibiotics, antifungals and antivirals, together with associated biological data and structure-activity relationships. Describes biosynthesis, total synthesis and partial (semi) synthesis of a wide variety of agents, including: lactams, oxazolidinones, streptogramins, azoles nucleosides and their analogues, strobilurin analogues, peptides and macrolides. It addresses a variety of microbial targets, such as reverse transcriptase, sialidase, cysteine proteases, chitin synthase, --lactamase, cell wall biosynthesis, signal peptidase, 14a-demethylase, HIV protese, as well as iron transport mechanisms, tubulins and mitochondrial respiration. Anti-Infectives highlights the seriousness of microbial resistance developing to mainline antimicrobials, and the work contained in it is bound to contribute to combating this resistance in the future. Contents clean, tight and bright. Book.