pin jean philippe (27 risultati)

Condizione: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Condizione: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

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Condizione: Neuf.

Condizione: Neuf.

Condizione: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Condizione: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

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Condizione: New. pp. 548 1st Edition.

Condizione: New. pp. 548.

Condizione: New. pp. 548.

Encuadernación de tapa dura. Condizione: Nuevo. Idioma español. Ilustrado. Encuadernación de tapa dura editorial.

Condizione: New. This is a Brand-new US Edition. This Item may be shipped from US or any other country as we have multiple locations worldwide.

Condizione: Brand New. New. US edition. Expediting shipping for all USA and Europe orders excluding PO Box. Excellent Customer Service.

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Hardcover. Condizione: new. Hardcover. G protein-coupled receptors (GPCRs) are the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins, and even light. Ligands (agonists and antagonists) acting on GPCRs are important in the treatment of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs. The determination of rhodopsin crystal structure and, more recently, of opsin, 1 and 2 adrenergic and A2A adenosine receptors provides both academia and industry with extremely valuable data for a better understanding of the molecular determinants of receptor function and a more reliable rationale for drug design. GPCR structure and function constitutes a hot topic. The book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details new insights on the link between structure and mechanism and their implications in drug design. This book considers the relationship between structure and function in G protein-coupled receptors (GPCRs) and the implications for drug design. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

Hardcover. Condizione: Like New. LIKE NEW. SHIPS FROM MULTIPLE LOCATIONS. book.

Condizione: New.

Hardcover. Condizione: New. Brand New! Fast Delivery This is an International Edition and ship within 24-48 hours. Deliver by FedEx and Dhl, & Aramex, UPS, & USPS and we do accept APO and PO BOX Addresses. Order can be delivered worldwide within 6-10 days and we do have flat rate for up to 2LB. Extra shipping charges will be requested if the Book weight is more than 5 LB. This Item May be shipped from India, United states & United Kingdom. Depending on your location and availability.

Condizione: New. Brand New! Fast Delivery This is an International Edition and ship within 24-48 hours. Deliver by FedEx and Dhl, & Aramex, UPS, & USPS and we do accept APO and PO BOX Addresses. Order can be delivered worldwide within 6-10 days and we do have flat rate for up to 2LB. Extra shipping charges will be requested if the Book weight is more than 5 LB. This Item May be shipped from India, United states & United Kingdom. Depending on your location and availability.

Hardcover. Condizione: Brand New. 1st edition. 548 pages. 9.30x6.30x1.30 inches. In Stock.

Buch. Condizione: Neu. Neuware - G protein-coupled receptors (GPCRs) constitute the largest family of cell-surface receptors, with more than 800 members identified thus far in the human genome. They regulate the function of most cells in the body, and represent approximately 3% of the genes in the human genome. These receptors respond to a wide variety of structurally diverse ligands, ranging from small molecules, such as biogenic amines, nucleotides and ions, to lipids, peptides, proteins and even light. Ligands (agonists and antagonists) acting on GPCRs are important commonly used in drug therapy of numerous diseases, including cardiovascular and mental disorders, retinal degeneration, cancer, and AIDS. It is estimated that these receptors represent about one third of the actual identified targets of clinically used drugs. This book, which lies between the fields of chemical biology, molecular pharmacology and medicinal chemistry, is divided into three parts. The first part considers what receptor structures tell us about the mechanism of receptor activation. Part II focuses on receptor function. It discusses what the data from biophysical and mutational studies, and the analysis of the interactions of the receptor with ligands and regulator proteins, tell us about the process of signal transduction. The final part, on modelling and simulation, details what new insights on the link between structure and mechanism can be provided by theoretical studies and their implications in drug design. The various chapters present an update on the latest developments in GPCR structures and detailed structural changes linked to activation. They cover the latest news of the extraordinary complex function of these receptors, concentrating on the many aspects that are currently revolutionizing our current views of these proteins: receptor constitutive activity, receptor oligomerization, functional selectivity, biased agonism, multiple signalling pathways, multiple accessory proteins, functional cross talk and the mechanism of signal integration. This complex picture is tackled from complementary experimental and theoretical approaches, which represent a clear statement of our current knowledge of the GPCR complexity.

Paperback. Condizione: Good. pp. 234 / illustrated by Villon, Gimond, Grüber, Marchand, Despierre, brassaï, Gischia, uncut pages/onopengesneden French.

1945. Paris Éditions de La Table Ronde 1945 - Broché couv. rempliée 25 5 cm x28 5 cm 227 pages - Exemplaire n° 1993 un des 2000 sur Vélin Crèvecoeur des papeteries du Marais - Texte collectif - Au sommaire : Jean RACINE : Principes de La Tragédie tirés de la Poétique d' Aristote - André SUARES avec Maïa - Jules ROMAINS : Nomentanus Le Réfugié - Daniel HALEVY : Nouveau Discours sur L'Histoire Universelle - Marcel AYME : Samson - Philippe HERIAT : Les Amours Bourgeoises - Patrice de LA TOUR DU PIN : Poèmes d'enfants - Pierre BOUTANG : Chez Madame Dorlinde - DESSINS de : Jacques VILLON Marcel GIMOND Francis GRÜBER André MARCHAND Jacques DESPIERRE BRASSAÏ Léon GISCHIA - Cet ouvrage se termine par un Fac-simile d'une lettre de LOUIS XIII au CARDINAL de RICHELIEU - Textes réunis par Thierry MAULNIER -- En partie non coupé - Très bon état. Bon état.

Textes réunis par Thierry Maulnier. Exemplaire numéroté sur vélin crème du Marais. Dos restauré. [16573].

Condizione: Bon. Participations de Fernand Mazade, André Salmon, Philippe ChabaneixYves-Gérard Le Dantec, Henri Céard, Fernand Fleuret, Max Jacob, Robert Houdelot, Maurice Chapelan, PJ Toulet, Patrice de la Tour du Pin, Jacques Reynaud, Roland RavetonJean Follain, Violette Rieder, Jean Pourtal de Ladevèze, Charles Forot, Claude Fourcade, Lucien Bastard, Lorenzo VeroVincent Muselli, Francis Carco, Guy-Charles Cros, Maurice Rey, André Blanchard. Complet du bulletion d'abonnement.(100839) 193x143mm Pas de jaquette Couverture souple.

Gamma-Film 1955. Dossier de presse de 4 pages à l'italienne au format 48 x 31 cm. Superbes couvertures illustrée en couleurs par Pierre-Laurent Brenot et Jean David. Rare dossier de presse pour le film film franco-italien : Frou-frou, réalisé en 1955 par Augusto Genina. Présentation du film avec photographies en noir. On trouve dans les rôles principaux : Dany Robin, Louis de Funès, Gino Cervi, Philippe Lemaire, Daniel Ceccaldi, Béatrice Arnac, Mylène Demongeot, , etc. Le dossier a été plié en son milieu, sinon bel état de fraicheur. Tirage limité réservé aux journalistes, diffuseurs et salles de cinéma. Précieux exemplaire de toute rareté avec belle dédicace autographe signée de l'acteur Philippe Lemaire.