yongxia zhou (152 risultati)

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Paperback. Condizione: new. Paperback. The aim of this new book is to provide readers some new insights into applying various imaging techniques to diagnose and distinguish subtypes and rare/comorbid cases of several brain disorders more accurately. Specific and comprehensive imaging features utilized that could pinpoint the exact abnormalities of these atypical and/or rare diseases are the highlights of this book, which will provide guidance for better disease mechanism interpretation. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

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Paperback. Condizione: new. Paperback. Multiple advanced neuroimaging applications in various neurodegenerative diseases including Parkinson's disease (PD), frontotemporal dementia (FTD), vascular dementia (VaD) and autism spectrum disorder (ASD) are covered in this book. Relatively novel techniques such as integrated PET/MRI and independent component analysis (ICA)-based dual regression (DR) methods were developed to capture multi-level molecular/functional and structural/microstructural as well as high-order inter-network coordination abnormalities. For instance, both PET dopamine transporter and striatal binding ratio reductions in the caudate and putamen were found in PD, consistent with the diffusion tensor imaging (DTI) fractional anisotropy (FA) reduction and fMRI voxel-mirrored homotopic correlation (VMHC) in the substantia nigra (swallow tail sign signature of PD). Furthermore, dopamine storage and pathway labeled with the vesicular monoamine transporter tracer identified decreased densities in the bilateral mesial temporal cortex, caudate, orbitofrontal cortex, left frontal and occipital cortices, consistent with the morphological atrophy, functional connectivity and conductivity deficits in PD. Similarly in FTD patients, the advanced MRI methods such as ICA-DR, VMHC, voxel-based morphometry (VBM) as well as PET tracer for amyloid accumulation and FDG glucose uptake identified typical brain atrophy, structural dis-connectivity, glucose hypometabolism, higher neuropathological burden, lower interhemispheric correlation as well as disrupted intra- and inter-network modulation in the orbitofrontal and anterior temporal cortices together with insular and frontoparietal networks, with the cerebellum and dorsolateral attentional network as typical compensations. Functional and structural abnormalities had further been elucidated in the VaD dependent participants and autistic children. For instance, both lower FA and VMHC, brain atrophy and functional connectivity deficits, demyelination, axonal degeneration and white matter integrity damage in several white matter tracts were present in the dependent compared to independent participants in VaD data cohort. Increased neuronal activity with higher global fractional amplitude of low frequency fluctuation (fALFF) in the conventional and slow-wave sub-band was confirmed with less efficiency of systematic integration in VaD dependent group. Moreover, in ASD compared to controls, regional gray matter volume and cortical thickness in all four brain lobes increased, whereas white matter volume were decreased in addition to the lower temporal, visual and superior frontal but higher inferior and dorsolateral prefrontal cortical functional connectivities exhibited in ASD. The differences in each type of disease could also be revealed with the same imaging method based on either unique region or distinct brain circuit inter-connection, using VMHC, ICA-DR, DTI, VBM, fALFF and graph-theory based small-worldness analysis. In this book, we have developed and generalized conventional and advanced imaging methodologies to several common neurodegenerative diseases. For instance, we have identified the unique imaging signature for each disease type and the underlying neuropathological mechanism connections with conductivity, structural and microstructural connectivity, intra- and inter-network correlation, systematic integration and efficiency analyses. Our objective, comprehensive and confirmative results indicated great potential in utilizing these quantifications for accurate disease classification and staging. With solid imaging evidence, thorough analysis and generalized applications, this book should capture the interests of readers in the broad fields of brain science, disease diagnosis and effective treatment. Shipping may be from multiple locations in the US or from the UK, depending on stock availability.

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Paperback. Condizione: New. The aim of this new book is to provide readers some new insights into applying various imaging techniques to diagnose and distinguish subtypes and rare/comorbid cases of several brain disorders more accurately. Specific and comprehensive imaging features utilized that could pinpoint the exact abnormalities of these atypical and/or rare diseases are the highlights of this book, which will provide guidance for better disease mechanism interpretation.

Paperback. Condizione: New. Multiple advanced neuroimaging applications in various neurodegenerative diseases including Parkinson's disease (PD), frontotemporal dementia (FTD), vascular dementia (VaD) and autism spectrum disorder (ASD) are covered in this book. Relatively novel techniques such as integrated PET/MRI and independent component analysis (ICA)-based dual regression (DR) methods were developed to capture multi-level molecular/functional and structural/microstructural as well as high-order inter-network coordination abnormalities. For instance, both PET dopamine transporter and striatal binding ratio reductions in the caudate and putamen were found in PD, consistent with the diffusion tensor imaging (DTI) fractional anisotropy (FA) reduction and fMRI voxel-mirrored homotopic correlation (VMHC) in the substantia nigra (swallow tail sign signature of PD). Furthermore, dopamine storage and pathway labeled with the vesicular monoamine transporter tracer identified decreased densities in the bilateral mesial temporal cortex, caudate, orbitofrontal cortex, left frontal and occipital cortices, consistent with the morphological atrophy, functional connectivity and conductivity deficits in PD. Similarly in FTD patients, the advanced MRI methods such as ICA-DR, VMHC, voxel-based morphometry (VBM) as well as PET tracer for amyloid accumulation and FDG glucose uptake identified typical brain atrophy, structural dis-connectivity, glucose hypometabolism, higher neuropathological burden, lower interhemispheric correlation as well as disrupted intra- and inter-network modulation in the orbitofrontal and anterior temporal cortices together with insular and frontoparietal networks, with the cerebellum and dorsolateral attentional network as typical compensations. Functional and structural abnormalities had further been elucidated in the VaD dependent participants and autistic children. For instance, both lower FA and VMHC, brain atrophy and functional connectivity deficits, demyelination, axonal degeneration and white matter integrity damage in several white matter tracts were present in the dependent compared to independent participants in VaD data cohort. Increased neuronal activity with higher global fractional amplitude of low frequency fluctuation (fALFF) in the conventional and slow-wave sub-band was confirmed with less efficiency of systematic integration in VaD dependent group. Moreover, in ASD compared to controls, regional gray matter volume and cortical thickness in all four brain lobes increased, whereas white matter volume were decreased in addition to the lower temporal, visual and superior frontal but higher inferior and dorsolateral prefrontal cortical functional connectivities exhibited in ASD. The differences in each type of disease could also be revealed with the same imaging method based on either unique region or distinct brain circuit inter-connection, using VMHC, ICA-DR, DTI, VBM, fALFF and graph-theory based small-worldness analysis. In this book, we have de.

Paperback. Condizione: New. Maintaining good metabolic profile plays a significant role in improving the quality of life at aging. Widely recommended physical and psychological strategies include exercise, calorie restriction (such as healthy diet), anti-aging neuroprotective and anti-inflammation therapy. Most occurring risks at middle age range (45-65 years old) are obesity, insulin resistance, inflammation, alteration in the hypothalamus-hypophysis suprarenal axis activity, stress and hypertension that could increase the prevalence of metabolic syndrome. Metabolic syndrome increases with age, particularly for women. Significant associations were seen between imaging measures and cardiovascular risk factors at both baseline and 18-month follow-ups. Both baseline and longitudinal imaging analysis and correlations with neurocogntive tests as well as cardiovascular risk factors could provide distinct and confirmative perspectives relating to the pathophysiology of aging-related diseases such as dementia and diabetes. Significant baseline and longitudinal effects of age, smoking and neuropathological burdens such as amyloid, tau and glucose metabolism provide a complete imaging, neurocognitive and cardiovascular profile for better staging and differentiating different diseases. Together with accurate imaging guidance, early detection and treatment could be achieved with the ultimate goal of improving quality of life at middle age and extending longevity. The aim of this book is intended to provide both beginners and experts in biomedical imaging and health care a broad picture as well as new development in brain function and metabolism of aging using innovative neuroimaging techniques and advanced longitudinal /correlational analyses. Methods and data presented in this book with novel experimental designs and protocols, especially longitudinal investigation of multiple imaging metrics from microvascular, micro-structural to systematic functional, metabolic and neuropathological perspectives will help improving diagnosis and early prevention of common diseases at middle age such as metabolic syndrome and early dementia. Some promising prevention strategies such as arts therapy, aerobic exercise and calorie restriction will be introduced additionally with imaging evidence. Results presented will help improving diagnosis accuracy, staging, and determining phases and trajectories of disease progression with age, endothelial dysfunction and deficits in metabolic syndrome. This book will provide the current state-of-the-art and new frontiers of brain function and metabolic changes at age using multi-parametric functional, structural and molecular imaging techniques in detection, diagnosis and treatment. We will present some forefront and interesting multi-dimensional baseline and longitudinal imaging techniques to serve as a reference and resource book in neuroimaging application and research field. Several distinct detection and application perspectives, including cutting-edge ima.

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