academic press jan 2017 (65 risultati)

Taschenbuch. Condizione: Neu. Neuware.

Buch. Condizione: Neu. Neuware -Parkinson's Disease: Molecular Mechanisms Underlying Pathology explores the molecular pathways at the basis of the cellular defects connected to Parkinson's disease, the second most common neurodegenerative disease, and the most common movement disorder. This book presents the latest research on the pathways and mechanisms that have been discovered to play a role in Parkinson's pathology. This focus on mechanisms rather than individual genes allows the contributors to elaborate on overlapping and joint functions of different causative genes. Readers will find descriptions of model systems that present parallels (and differences) between discoveries in different species, demonstrating the importance of multidisciplinary research that spans a broad array of technologies and model organisms. Written from both a cross-methodology and cross-species perspective, the book provides readers with the current state of knowledge on the molecular biology of Parkinson's. Englisch.

Taschenbuch. Condizione: Neu. Neuware - 'Today with the Red Army captive and disarmed, the Nationalist [nacionales] troops have achieved their final military objectives. The war is over.' With these two sentences, on 1 April 1939, General Franco announced that his writ ran across the whole of Spain. His words marked a high point for those who had flocked to Franco's side and since the start of the Civil War in July 1936 had carried out what they regarded as the steady occupation of the country. The history of this occupation remains conspicuous by its absence and the term occupation lies discredited for many historians. The danger of leaving the history of the occupation unexplored, however, is that a major process designed to control the conquered population remains in the shadows and, unlike many other European countries, the view of occupation as an imposition by outsiders remains unchallenged. This book explores how Francoist occupation saw members of the state and society collaborate to win control of Spanish society. At the heart of the process lay the challenging task in civil war of distinguishing between supporter and opponent. Occupation also witnessed a move from arbitrary violence towards selecting opponents for carefully graded punishment. Such selection depended upon fine-grained information about vast swathes of the population. The massive scale of the surveillance meant that regime officials depended on collaborators within the community to furnish them with the information needed to write huge numbers of biographies. Accordingly, knowledge as a form of power became as crucial as naked force as neighbours of the defeated helped define who would gain reward as a friend and who would suffer punishment as a foe.

Taschenbuch. Condizione: Neu. Neuware - The Spanish Civil War, fought between 1936 and 1939, was the first battle against fascism in Europe. Five months after the victory of dictator Francisco Franco in Spain the conflict moved to Europe with the outbreak of the Second World War. Fascism and anti-fascism again faced each other on the battlefield. Amid the heat of the Nazi invasions in Europe, anti-fascist resistance groups formed by ordinary citizens emerged in virtually all European countries. Although the Franco dictatorship was not directly involved in the world war, in Spain an anti-Franco resistance movement was organized in 1939 and lasted until 1952. Although the Spanish resistance constituted the first and last anti-fascist resistance movement in Europe, the Spanish case has been consistently overlooked by international studies. This book inserts the Spanish anti-Franco resistance into the European context, proposing a new narrative of anti-fascist resistances in Europe. At the same time, the book offers a new interpretation of guerrilla phenomena with a strongly peasant character, as was the case of the resistance in Spain. The author underlines the importance of primary groups (kinship, neighbourhood, friendship) and secondary groups (camaraderie and political loyalties) in the mobilisation and organisation of armed groups. For this study, Jorge Marco establishes twelve variables that permit him to distinguish between 'neighbours in arms' and 'modern guerrilla'. The studied combinations of groups and types demonstrates the plurality of the identities and cultures of the anti-fascist resistance in Spain. Published in association with the Canada Blanch Centre for Contemporary Spanish Studies.

Buch. Condizione: Neu. Neuware - An investigation of US participation in the transatlantic slave trade to the Americas, from the American Revolution to the Civil War.

Buch. Condizione: Neu. Neuware - When a new technology makes people ill, how high does the body count have to be before protectives steps are taken.

Buch. Condizione: Neu. Neuware - The first archive-based study of official corruption under Stalin and a compelling new look at the textures of everyday Soviet life after World War II.

Buch. Condizione: Neu. Neuware - A bold and original study of German missionaries in China, who catalyzed a revolution in thinking among European Christians about the nature of Christianity itself.

Taschenbuch. Condizione: Neu. Neuware - Up and Running with AutoCAD 2017: 2D and 3D Drawing and Modeling presents Gindis' combination of step-by-step instruction, examples, and insightful explanations. The emphasis from the beginning is on core concepts and practical application of AutoCAD in engineering, architecture, and design. Equally useful in instructor-led classroom training, self-study, or as a professional reference, the book is written with the user in mind by a long-time AutoCAD professional and instructor based on what works in the industry and the classroom.

Buch. Condizione: Neu. Neuware - This title includes a number of Open Access chapters.

Buch. Condizione: Neu. Neuware.

Buch. Condizione: Neu. Neuware - This important volume, Soil Salinity Management in Agriculture, addresses the crucial issue of soil salinity of potential farmland and provides a comprehensive picture of the saline environment and plant interactions, along with management and reclamation methods and policies. With contributions from researchers from the fields of agricultural chemistry, soil science, biotechnology, agronomy, environmental sciences, and plant breeding and genetics, the volume emphasizes a multidisciplinary approach.

Taschenbuch. Condizione: Neu. Neuware.

Buch. Condizione: Neu. Neuware - The Vitamins: Fundamental Aspects in Nutrition and Health, Fifth Edition, provides the latest coverage of the biochemistry and physiology of vitamins and vitamin-like substances. Health-related themes present insights into the use of vitamins, not only for general nutritional balance, but also as a factor in the prevention and/or treatment of specific health issues, such as overall immunity, inflammatory diseases, obesity, and anemia. Readers will gain an understanding of the roles vitamins play in gene expression and epigenetics, providing important information on the further development of personalized medical treatments that will also allow them to establish appropriate dietary programs based on individual genetic profiles. This cohesive, well-organized presentation of each vitamin includes key words, case studies, and coverage of the metabolic functions of appropriate vitamins. The readability of this complex content is highly regarded by students, instructors, researchers, and professionals alike.

Buch. Condizione: Neu. Neuware - \*Child Actors on the London Stage, c 1600 by Julie Ackroyd has been shortlisted for the Society for Theatre Researchs Book prize! Actor and playwright Rory Kinnear (National Theatre, RSC, James Bond franchise) will announce who has won the STR Theatre Book Prize for books published in 2017 and make the presentation at the historic Theatre Royal, Drury Lane, on Thursday 21 June 2018.\* A legal document dated 1600, for a Star Chamber case titled Clifton versus Robinson, details how boys were abducted from London streets and forcibly held in order to train them as actors for the Blackfriars theatre. No adults were seen on-stage in this theatre, which was stocked solely by acting boys, resulting in a satirical and scurrilous method of play presentation. Were the boys specifically targeted for skills they may have possessed which would have been applicable to this type of play presentation And, was this method of recruitment typical or atypical of Elizabethan theatre Analysis of the background of the boy subjects of the legal case indicate that several had received grammar-school tuition and, as a result, would have possessed skills in oration and rhetoric. Indeed, a significant number of the grammar schools in London provided regular public disputations and theatrical performances which would have made these boys an attractive proposition for inclusion in a theatrical company. The styles of play-texts which the boys performed and their manner of presenting characters helps to assess why child acting companies were commercially viable and popular. Their portrayal of all roles in a performance; young and old, male and female, clearly demonstrated their versatility and skill in mimicry and the adoption of other personas. Therefore the taking of grammar-school boys for re-training as actors was not opportunistic; their abductions were planned. The theatre owners undertook this method of recruitment as they felt that they were immune from prosecution due to holding royal commissions which they used to recruit boys. However, the Clifton vs. Robinson case clearly demonstrates that a determined parent whose child had been taken could challenge this and demand reparation.

Buch. Condizione: Neu. Neuware - Molecular Diagnostics, Third Edition, focuses on the technologies and applications that professionals need to work in, develop, and manage a clinical diagnostic laboratory. Each chapter contains an expert introduction to each subject that is next to technical details and many applications for molecular genetic testing that can be found in comprehensive reference lists at the end of each chapter. Contents are divided into three parts, technologies, application of those technologies, and related issues. The first part is dedicated to the battery of the most widely used molecular pathology techniques. New chapters have been added, including the various new technologies involved in next-generation sequencing (mutation detection, gene expression, etc.), mass spectrometry, and protein-specific methodologies. All revised chapters have been completely updated, to include not only technology innovations, but also novel diagnostic applications. As with previous editions, each of the chapters in this section includes a brief description of the technique followed by examples from the area of expertise from the selected contributor. The second part of the book attempts to integrate previously analyzed technologies into the different aspects of molecular diagnostics, such as identification of genetically modified organisms, stem cells, pharmacogenomics, modern forensic science, molecular microbiology, and genetic diagnosis. Part three focuses on various everyday issues in a diagnostic laboratory, from genetic counseling and related ethical and psychological issues, to safety and quality management.

Buch. Condizione: Neu. Neuware - Quantitative Human Physiology: An Introduction, winner of a 2018 Textbook Excellence Award (Texty), is the first text to meet the needs of the undergraduate bioengineering student who is being exposed to physiology for the first time, but requires a more analytical/quantitative approach. This book explores how component behavior produces system behavior in physiological systems. Through text explanation, figures, and equations, it provides the engineering student with a basic understanding of physiological principles with an emphasis on quantitative aspects.

Buch. Condizione: Neu. Neuware - A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings.

Buch. Condizione: Neu. Neuware - Cardioskeletal Myopathies in Children and Young Adults focuses on plaques that kill people in their 40's-50's and the way they start to form in young adulthood. The Annals of Family Medicine report that approximately half of young adults have at least one cardiovascular disease risk factor (Mar 2010), and an increase in cardiovascular mortality rates in young adults was substantiated in a study at Northwestern Medicine (Nov 2011). Given the increasing recognition of genetic triggers behind all types of cardiovascular disease, and the growing population of young adults with primary or acquired myocardial disease, the need has arisen for a reference that offers a comprehensive approach to the understanding of basic, translational, and clinical aspects of specific muscle diseases while making the link between young adult and adult health.

Buch. Condizione: Neu. Neuware - Developing Solid Oral Dosage Forms: Pharmaceutical Theory and Practice, Second Edition illustrates how to develop high-quality, safe, and effective pharmaceutical products by discussing the latest techniques, tools, and scientific advances in preformulation investigation, formulation, process design, characterization, scale-up, and production operations. This book covers the essential principles of physical pharmacy, biopharmaceutics, and industrial pharmacy, and their application to the research and development process of oral dosage forms. Chapters have been added, combined, deleted, and completely revised as necessary to produce a comprehensive, well-organized, valuable reference for industry professionals and academics engaged in all aspects of the development process. New and important topics include spray drying, amorphous solid dispersion using hot-melt extrusion, modeling and simulation, bioequivalence of complex modified-released dosage forms, biowaivers, and much more.

Buch. Condizione: Neu. Neuware - Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles aligned in five main subject sections, with new chapters included on genetic and genomic techniques and clinical investigations. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields.

Buch. Condizione: Neu. Neuware - Evolution of Nervous Systems, Second Edition, Four Volume Set is a unique, major reference which offers the gold standard for those interested both in evolution and nervous systems. All biology only makes sense when seen in the light of evolution, and this is especially true for the nervous system. All animals have nervous systems that mediate their behaviors, many of them species specific, yet these nervous systems all evolved from the simple nervous system of a common ancestor. To understand these nervous systems, we need to know how they vary and how this variation emerged in evolution. In the first edition of this important reference work, over 100 distinguished neuroscientists assembled the current state-of-the-art knowledge on how nervous systems have evolved throughout the animal kingdom. This second edition remains rich in detail and broad in scope, outlining the changes in brain and nervous system organization that occurred from the first invertebrates and vertebrates, to present day fishes, reptiles, birds, mammals, and especially primates, including humans. The book also includes wholly new content, fully updating the chapters in the previous edition and offering brand new content on current developments in the field. Each of the volumes has been carefully restructured to offer expanded coverage of non-mammalian taxa, mammals, primates, and the human nervous system. The basic principles of brain evolution are discussed, as are mechanisms of change. The reader can select from chapters on highly specific topics or those that provide an overview of current thinking and approaches, making this an indispensable work for students and researchers alike.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Introduction to Robust Estimating and Hypothesis Testing, 4th Editon, is a 'how-to' on the application of robust methods using available software. Modern robust methods provide improved techniques for dealing with outliers, skewed distribution curvature and heteroscedasticity that can provide substantial gains in power as well as a deeper, more accurate and more nuanced understanding of data. Since the last edition, there have been numerous advances and improvements. They include new techniques for comparing groups and measuring effect size as well as new methods for comparing quantiles. Many new regression methods have been added that include both parametric and nonparametric techniques. The methods related to ANCOVA have been expanded considerably. New perspectives related to discrete distributions with a relatively small sample space are described as well as new results relevant to the shift function. The practical importance of these methods is illustrated using data from real world studies. The R package written for this book now contains over 1200 functions. New to this edition 35% revised content Covers many new and improved R functions New techniques that deal with a wide range of situations Extensive revisions to cover the latest developments in robust regression Covers latest improvements in ANOVA Includes newest rank-based methods Describes and illustrated easy to use software 810 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Psychology of Criminal and Antisocial Behavior: Victim and Offenders Perspectives is not just another formulaic book on forensic psychology. Rather, it opens up new areas of enquiry to busy practitioners and academics alike, exploring topics using a practical approach to social deviance that is underpinned by frontier research findings, policy, and international trends. From the relationship between psychopathology and crime, and the characteristics of catathymia, compulsive homicide, sadistic violence, and homicide victimology, to adult sexual grooming, domestic violence, and honor killings, experts in the field provide insight into the areas of homicide, violent crime, and sexual predation. In all, more than 20 internationally recognized experts in their fields explore these and other topic, also including discussing youth offending, love scams, the psychology of hate, public threat assessment, querulence, stalking, arson, and cults. This edited work is an essential reference for academics and practitioners working in any capacity that intersects with offenders and victims of crime, public policy, and roles involving the assessment, mitigation, and investigation of criminal and antisocial behavior. It is particularly ideal for those working in criminology, psychology, law and law enforcement, public policy, and for social science students seeking to explore the nature and character of criminal social deviance. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Big Mechanisms in Systems Biology: Big Data Mining, Network Modeling, and Genome-Wide Data Identification explains big mechanisms of systems biology by system identification and big data mining methods using models of biological systems. Systems biology is currently undergoing revolutionary changes in response to the integration of powerful technologies. Faced with a large volume of available literature, complicated mechanisms, small prior knowledge, few classes on the topics, and causal and mechanistic language, this is an ideal resource. This book addresses system immunity, regulation, infection, aging, evolution, and carcinogenesis, which are complicated biological systems with inconsistent findings in existing resources. These inconsistencies may reflect the underlying biology time-varying systems and signal transduction events that are often context-dependent, which raises a significant problem for mechanistic modeling since it is not clear which genes/proteins to include in models or experimental measurements. The book is a valuable resource for bioinformaticians and members of several areas of the biomedical field who are interested in an in-depth understanding on how to process and apply great amounts of biological data to improve research. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -PCR Guru: An Ultimate Benchtop Reference for Molecular Biologists is provides researchers in molecular biology with a handy reference for approaching and solving challenging problems associated with PCR setup and optimization. As a laboratory guide, it emphasizes the technical aspects of employing PCR as a tool in molecular biology laboratories. The book covers the history of PCR and the basic science underlying it. It then discusses PCR at the bench level, starting with detailed description and tips on primer design, and continuing with the standard protocols used to perform PCR. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Soil and Environmental Chemistry, Second Edition, presents key aspects of soil chemistry in environmental science, including dose responses, risk characterization, and practical applications of calculations using spreadsheets. The book offers a holistic, practical approach to the application of environmental chemistry to soil science and is designed to equip the reader with the chemistry knowledge and problem-solving skills necessary to validate and interpret data. This updated edition features significantly revised chapters, averaging almost a 50% revision overall, including some reordering of chapters. All new problem sets and solutions are found at the end of each chapter, and linked to a companion site that reflects advances in the field, including expanded coverage of such topics as sample collection, soil moisture, soil carbon cycle models, water chemistry simulation, alkalinity, and redox reactions. There is also additional pedagogy, including key term and real-world scenarios. This book is a must-have reference for researchers and practitioners in environmental and soil sciences, as well as intermediate and advanced students in soil science and/or environmental chemistry. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Pharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book allow for the application of more predictive pharmacological procedures aimed at increasing therapeutic efficacy that will lead to more successful drug development. Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. This edition has been fully revised to address the latest advances and research related to real time kinetic assays, pluridimensional efficacy, signaling bias, irreversible and chemical antagonism, allosterically-induced bias, pharmacokinetics and safety, target and pathway validation, and much more. With numerous valuable chapter summaries, detailed references, practical examples and case studies throughout, Dr. Kenakin successfully navigates a highly complex subject, making it accessible for students, professors, and new researchers working in pharmacology and drug discovery. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Stress Testing and Risk Integration in Banks provides a comprehensive view of the risk management activity by means of the stress testing process. An introduction to multivariate time series modeling paves the way to scenario analysis in order to assess a bank resilience against adverse macroeconomic conditions. Assets and liabilities are jointly studied to highlight the key issues that a risk manager needs to face. A multi-national bank prototype is used all over the book for diving into market, credit, and operational stress testing. Interest rate, liquidity and other major risks are also studied together with the former to outline how to implement a fully integrated risk management toolkit. Examples, business cases, and exercises worked in Matlab and R facilitate readers to develop their own models and methodologies. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -An Invitation to Applied Mathematics: Differential Equations, Modeling, and Computation introduces the reader to the methodology of modern applied mathematics in modeling, analysis, and scientific computing with emphasis on the use of ordinary and partial differential equations. Each topic is introduced with an attractive physical problem, where a mathematical model is constructed using physical and constitutive laws arising from the conservation of mass, conservation of momentum, or Maxwell's electrodynamics. Relevant mathematical analysis (which might employ vector calculus, Fourier series, nonlinear ODEs, bifurcation theory, perturbation theory, potential theory, control theory, or probability theory) or scientific computing (which might include Newton's method, the method of lines, finite differences, finite elements, finite volumes, boundary elements, projection methods, smoothed particle hydrodynamics, or Lagrangian methods) is developed in context and used to make physically significant predictions. The target audience is advanced undergraduates (who have at least a working knowledge of vector calculus and linear ordinary differential equations) or beginning graduate students. Readers will gain a solid and exciting introduction to modeling, mathematical analysis, and computation that provides the key ideas and skills needed to enter the wider world of modern applied mathematics. Englisch.