basel springer basel springer okt 2010 (9 risultati)

Buch. Condizione: Neu. Neuware -The book contains articles from leading experts in different areas of biological physics. Topics ranging from cell dynamics to the evolution of multicellularity to conscious versus non-conscious evidence accumulation are reviewed and discussed, both from a theoretical and an experimental perspective. Furthermore, current developments of practical applications like magnetic tweezers for the study of DNA replication and brain imaging are presented.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 180 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -Since the publication of the first edition of this seminar book in 1994, the theory and applications of extremes and rare events have enjoyed an enormous and still increasing interest. The intention of the book is to give a mathematically oriented development of the theory of rare events underlying various applications. This characteristic of the book was strengthened in the second edition by incorporating various new results. In this third edition, the dramatic change of focus of extreme value theory has been taken into account: from concentrating on maxima of observations it has shifted to large observations, defined as exceedances over high thresholds. One emphasis of the present third edition lies on multivariate generalized Pareto distributions, their representations, properties such as their peaks-over-threshold stability, simulation, testing and estimation.Reviews of the 2nd edition:'In brief, it is clear that this will surely be a valuable resource for anyone involved in, or seeking to master, the more mathematical features of this field.'David Stirzaker, Bulletin of the London Mathematical Society'Laws of Small Numbers can be highly recommended to everyone who is looking for a smooth introduction to Poisson approximations in EVT and other fields of probability theory and statistics. In particular, it offers an interesting view on multivariate EVT and on EVT for non-iid observations, which is not presented in a similar way in any other textbook.'Holger Drees, MetrikaSpringer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 528 pp. Englisch.

Buch. Condizione: Neu. Neuware -Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders.Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML.This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 280 pp. Englisch.

Buch. Condizione: Neu. Neuware -The emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 460 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book deals with the symbiotic relationship between the theory of function spaces, fractal geometry, and spectral theory of (fractal) pseudodifferential operators as it has emerged quite recently. Most of the presented material is published here for the first time. 272 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This new volume in the Poincaré Seminar Series, describing recent developments at the interface between physics and biology, is directed towards a broad audience of physicists, biologists, and mathematicians. Both the theoretical and experimental aspects are covered, and particular care is devoted to the pedagogical nature of the presentations.The first survey article, by Jean-Francois Joanny and Jacques Prost, describes the theoretical advances made in the study of 'active gels', with applications to liquid crystals and cell motility. Jasper van der Gucht and Cécile Sykes then report on recent advances made with biomimetic model systems in the understanding of cytokinesis. The next article, by Jonathon Howard, presents several molecular models for motor proteins, which are compared with experimental results for kinesin. David Lacoste and Kirone Mallick then show theoretically that similar ratchet models of motor proteins naturally satisfy a fundamental time-reversal symmetry, the Gallavotti-Cohen fluctuation relation. Jean-Francois Allemand, David Bensimon and Vincent Croquette and their coauthors describe the latest advances made in the real-time single molecule study of the enzymes involved in DNA replication. Raymond E. Goldstein addresses the problem of understanding, from a physics perspective, the driving forces behind the biological evolution of multicellularity, using Volvocine algae as model organisms. Stanislas Dehaene finally addresses the major challenge of understanding the neuronal mechanism of consciousness, and speculates on the possible theoretical explanations of MRI experiments. 180 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Since the publication of the first edition of this seminar book in 1994, the theory and applications of extremes and rare events have enjoyed an enormous and still increasing interest. The intention of the book is to give a mathematically oriented development of the theory of rare events underlying various applications. This characteristic of the book was strengthened in the second edition by incorporating various new results. In this third edition, the dramatic change of focus of extreme value theory has been taken into account: from concentrating on maxima of observations it has shifted to large observations, defined as exceedances over high thresholds. One emphasis of the present third edition lies on multivariate generalized Pareto distributions, their representations, properties such as their peaks-over-threshold stability, simulation, testing and estimation.Reviews of the 2nd edition:'In brief, it is clear that this will surely be a valuable resource for anyone involved in, or seeking to master, the more mathematical features of this field.'David Stirzaker, Bulletin of the London Mathematical Society'Laws of Small Numbers can be highly recommended to everyone who is looking for a smooth introduction to Poisson approximations in EVT and other fields of probability theory and statistics. In particular, it offers an interesting view on multivariate EVT and on EVT for non-iid observations, which is not presented in a similar way in any other textbook.'Holger Drees, Metrika 528 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Epigenetics has emerged recently as an important area of molecular biological studies. Epigenetic modifications lead to potentially heritable but reversible alterations in the expression of genes that determine cell fate. Epigenetic misregulation is thus often linked to degenerative diseases, cancer and neuronal disorders.Recent biomedical interest in this regulatory system stems from the fact that epigenetic, in contrast to genetic, alterations are in principle amenable to pharmacological intervention. A few epigenetically active drugs, for example histone deacetylase inhibitors (HDACi) and DNA methyltransferase (DNMT) inhibitors, have been approved by FDA for treatment of cancers such as CTCL, MDS, and AML.This volume explores the scientific background for clinical applications of epigenetically active drugs. Included are descriptions of epigenetic controls over gene expression, the post-transcriptional silencing of genes by RNA interference (RNAi) and microRNAs, as well as new findings from stem cell research which are relevant to pharmacological applications. 280 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The threat constituted by the multiple outbreaks of avian influenza during the last few years is urgently calling for the development of new influenza vaccines. Fortunately, a quantum leap in technology has revolutionized the study of influenza and the engineering of new vaccine strains by reverse genetics. This volume provides a historical background and state-of-the-art information about the recent advances in the biology of influenza and the design of new influenza vaccines. 460 pp. Englisch.