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  • Henri Poincaré

    Editore: Birkhäuser Basel, Birkhäuser Basel Jan 2002, 2002

    ISBN 10: 3764365390 ISBN 13: 9783764365394

    Lingua: Inglese

    Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germania

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    Buch. Condizione: Neu. Neuware -During his lifetime, Henri Poincaré published three major philosophical books which achieved great success: 'La science et l'hypothèse' (1902), 'La valeur de la science' (1905) and 'Science et méthode' (1908). After his death in 1913, a fourth volume of his philosophical works was published by his heirs as 'Dernières pensées' (1913). The four books constitute the core of Poincaré's philosophic works and were given an ovation by scientific and general public. Around 1919, Gustave Le Bon wrote to Poincaré's widow. As the director of the 'Bibliothèque de Philosophie Scientifique at Flammarion', he asked her permission to publish a second posthumous volume. 'L'Opportunisme scientifique' was intended to be the fifth and final volume of Poincaré's philosophical writings. Louis Rougier had elaborated the project, with the collaboration of Gustave Le Bon, and the approval of the philosopher Émile Boutroux and his son Pierre. Because of the reservations of the mathematician's heirs, this book was never published and Dernières pensées remained his last philosophical book. Nevertheless Poincaré's correspondence - which is kept in the Poincaré Archives at University Nancy 2 - contains a large amount of documents concerning the project, its justification and the discussions between Louis Rougier and the mathematician's heirs. The aim of this book is to restore this episode, which gives some crucial informations about editorial practices of Poincaré and about the posterity of his philosophic thinking.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 240 pp. Englisch.

  • Ray G. Hill

    Editore: Birkhäuser Basel, Birkhäuser Basel Jan 2002, 2002

    ISBN 10: 3764360119 ISBN 13: 9783764360115

    Lingua: Inglese

    Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germania

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    Buch. Condizione: Neu. Neuware -Dalip J. S. Sirinathsinghii and Ray G. Hill Merck, Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK There remains a distinct medical need for new pain therapies. Therefore, it is not surprising that in recent years there has been a major research initiative in both aca demic and pharmaceutical laboratories to identify novel pain targets and to devel op novel analgesic drugs. It is clear from numerous studies that the NMDA recep tor plays a major role in the transmission ofnociceptive information and it has been a subject of extensive investigation over the last decade exploiting the advances of molecular pharmacology and molecular neuroanatomy. As a consequence there has been a rational approach by several laboratories to develop receptor subtype-spe cific NMDA antagonists in order to avoid the wide range of side-effects seen with non-selective NMDA ion channel antagonists such as ketamine. This volume brings together contributions from experts in various technological disciplines who have contributed immensely to NMDA receptor research and advanced our understanding of the subunit composition of the NMDA receptor complex, its pharmacology and distribution, its interaction with other neurochemi cal systems and the effects on behaviour of NMDA antagonists in rodent models and in the clinic. In consideration of these advances and the prospects of novel NMDA receptor antagonists in the near future for the treatment of pain, this vol ume is very timely. 208 pp. Englisch.

  • Margarita Del Rio Sanchez

    Editore: Birkhäuser Basel, Birkhäuser Basel Jan 2002, 2002

    ISBN 10: 3764362316 ISBN 13: 9783764362317

    Lingua: Inglese

    Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germania

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    Buch. Condizione: Neu. Neuware -This book contains reviews by a renowned group of clinicians and scientists, which consider in great depth the potential involvement of neurogenic inflammation in the pathogenesis of migraine and inhibition of this putative mechanism as a possible mode of action of antimigraine medications. The authors carefully consider current and future potential therapeutic approaches for the abortive as well as preventive treatment of migraine. The pioneering work by Professor Michael A. Moskowitz's group at Harvard gave rise to the 'neurogenic hypothesis' of migraine pathogenesis and to an intel lectual framework for many aspects of migraine research through a detailed phar macological characterization of the trigeminovascular system. This knowledge then spurred detailed research worldwide into the roles of the dural vasculature, trigem inal nerve fibers, and sensory neuropeptides, such as substance P and calcitonin gene-related peptide, in migraine. Similar in-depth investigations have not been made of the role of the seventh cranial parasympathetic nerves but this area war rants further study because of its potential for interactions with the trigeminovas cular system and its clear involvement in cluster headache.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 188 pp. Englisch.

  • Gerald Warnecke

    Editore: Birkhäuser Basel, Birkhäuser Basel Jan 2002, 2002

    ISBN 10: 3764367105 ISBN 13: 9783764367107

    Lingua: Inglese

    Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germania

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    Buch. Condizione: Neu. Neuware -Hyperbolic partial differential equations describe phenomena of material or wave transport in physics, biology and engineering, especially in the field of fluid mechanics. The mathematical theory of hyperbolic equations has recently made considerable progress. Accurate and efficient numerical schemes for computation have been and are being further developed.This two-volume set of conference proceedings contains about 100 refereed and carefully selected papers. The books are intended for researchers and graduate students in mathematics, science and engineering interested in the most recent results in theory and practice of hyperbolic problems.Applications touched in these proceedings concern one-phase and multiphase fluid flow, phase transitions, shallow water dynamics, elasticity, extended thermodynamics, electromagnetism, classical and relativistic magnetohydrodynamics, cosmology. Contributions to the abstract theory of hyperbolic systems deal with viscous and relaxation approximations, front tracking and wellposedness, stability of shock profiles and multi-shock patterns, traveling fronts for transport equations. Numerically oriented articles study finite difference, finite volume, and finite element schemes, adaptive, multiresolution, and artificial dissipation methods.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 488 pp. Englisch.

  • Ana M. Gasca

    Editore: Birkhäuser Basel, Birkhäuser Basel Jan 2002, 2002

    ISBN 10: 3764365145 ISBN 13: 9783764365141

    Lingua: Inglese

    Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germania

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    Buch. Condizione: Neu. Neuware -Foreword The modern developments in mathematical biology took place roughly between 1920 and 1940, a period now referred to as the 'Golden Age of Theoretical Biology'. The eminent Italian mathematician Vito Volterra played a decisive and widely acknowledged role in these developments. Volterra's interest in the application of mathematics to the non physical sciences, and to biology and economics in particular, dates back to the turn of the century and was expressed in his inaugural address at the University of Rome for the academic year 1900/01 (VOLTERRA 1901). Nevertheless, it was only in the mid-twenties that Volterra entered the field in person, at the instigation of his son in law, Umberto D'Ancona, who had confronted him with the problem of competition among animal species, asking him whether a mathematical treatment was possible. From that time on, until his death in 1940, Volterra produced a huge output of publications on the subject. Volterra's specific project was to transfer the model and the concepts of classical mechanics to biology, constructing a sort of 'rational mechanics' and an 'analytic mechanics' of biological associations. The new subject was thus to be equipped with a solid experimental or at least empirical basis, also in this case following the tried and tested example of mathematical physics. Although very few specific features of this reductionist programme have actually survived, Volterra's contribution was decisive, as is now universally acknowledged, in en couraging fresh studies in the field of mathematical biology.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 420 pp. Englisch.

  • R. Desalle

    Editore: Birkhäuser Basel, Springer Basel Jan 2002, 2002

    ISBN 10: 3764365447 ISBN 13: 9783764365448

    Lingua: Inglese

    Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germania

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    Buch. Condizione: Neu. Neuware -Important practical implications are established by case reports and specific examples. The present book is the ideal complement to the practitioner¿s manual Techniques in Molecular Systematics and Evolution, recently published by the same editors in the Birkhäuser MTBM book series.The first part of this book deals with important applications of evolutionary and systematic analysis at different taxonomic levels. The second part discusses DNA multiple sequence alignment, species designations using molecular data, evo-devo and other topics that are problematic or controversial. In the last part, novel topics in molecular evolution and systematics, like genomics, comparative methods in molecular evolution and the use of large data bases are described. The final chapter deals with problems in bacterial evolution, considering the increasing access to large numbers of complete genome sequences. 320 pp. Englisch.

  • Henri Poincaré

    Editore: Springer, Basel, Birkhäuser Basel, Birkhäuser Jan 2002, 2002

    ISBN 10: 3764365390 ISBN 13: 9783764365394

    Lingua: Inglese

    Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania

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    Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -During his lifetime, Henri Poincaré published three major philosophical books which achieved great success: 'La science et l'hypothèse' (1902), 'La valeur de la science' (1905) and 'Science et méthode' (1908). After his death in 1913, a fourth volume of his philosophical works was published by his heirs as 'Dernières pensées' (1913). The four books constitute the core of Poincaré's philosophic works and were given an ovation by scientific and general public. Around 1919, Gustave Le Bon wrote to Poincaré's widow. As the director of the 'Bibliothèque de Philosophie Scientifique at Flammarion', he asked her permission to publish a second posthumous volume. 'L'Opportunisme scientifique' was intended to be the fifth and final volume of Poincaré's philosophical writings. Louis Rougier had elaborated the project, with the collaboration of Gustave Le Bon, and the approval of the philosopher Émile Boutroux and his son Pierre. Because of the reservations of the mathematician's heirs, this book was never published and Dernières pensées remained his last philosophical book. Nevertheless Poincaré's correspondence - which is kept in the Poincaré Archives at University Nancy 2 - contains a large amount of documents concerning the project, its justification and the discussions between Louis Rougier and the mathematician's heirs. The aim of this book is to restore this episode, which gives some crucial informations about editorial practices of Poincaré and about the posterity of his philosophic thinking. 208 pp. Englisch.

  • Carlos Oliveira

    Editore: Birkhäuser Basel, Birkhäuser Basel Jan 2002, 2002

    ISBN 10: 3764366524 ISBN 13: 9783764366520

    Lingua: Inglese

    Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germania

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    Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -In many past and recent earthquakes it has been shown that the local conditions and, in particular, the local geology have a great influence on the observed seismic ground motion and, consequently, on the damage distribution in housing, industrial stock, and life-lines. Seismic microzoning is the usual procedure to have these local effects taken into account for engineering design and land-use planning, being a useful tool for earthquake risk mitigation. This volume presents a collection of papers mainly originated from a workshop on Seismic Microzoning, organized during the 23rd General Assembly of the European Geophysical Society (EGS) in Nice, France in April 1998. The workshop dealt with various geophysical tools for analysing the effects of the local soils of subsurface geology on seismic ground motion, namely the methods using experimental data such as microtremors, and the theoretical/numerical 1-D and 2-D modelling methods. Additional contributions discussing techniques for characterising soil properties, microzoning applications to several urban areas, and others were added to the volume to broaden this important topic.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 368 pp. Englisch.

  • Antoni Roca

    Editore: Springer, Basel, Birkhäuser Basel Jan 2002, 2002

    ISBN 10: 3764366524 ISBN 13: 9783764366520

    Lingua: Inglese

    Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania

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    Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In many past and recent earthquakes it has been shown that the local conditions and, in particular, the local geology have a great influence on the observed seismic ground motion and, consequently, on the damage distribution in housing, industrial stock, and life-lines. Seismic microzoning is the usual procedure to have these local effects taken into account for engineering design and land-use planning, being a useful tool for earthquake risk mitigation. This volume presents a collection of papers mainly originated from a workshop on Seismic Microzoning, organized during the 23rd General Assembly of the European Geophysical Society (EGS) in Nice, France in April 1998. The workshop dealt with various geophysical tools for analysing the effects of the local soils of subsurface geology on seismic ground motion, namely the methods using experimental data such as microtremors, and the theoretical/numerical 1-D and 2-D modelling methods. Additional contributions discussing techniques for characterising soil properties, microzoning applications to several urban areas, and others were added to the volume to broaden this important topic. 358 pp. Englisch.

  • Ian Stewart

    Editore: Birkhäuser Basel, Birkhäuser Basel Jan 2002, 2002

    ISBN 10: 3764366095 ISBN 13: 9783764366094

    Lingua: Inglese

    Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germania

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    Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Pattern formation in physical systems is one of the major research frontiers of mathematics. A central theme of this book is that many instances of pattern formation can be understood within a single framework: symmetry.The book applies symmetry methods to increasingly complex kinds of dynamic behavior: equilibria, period-doubling, time-periodic states, homoclinic and heteroclinic orbits, and chaos. Examples are drawn from both ODEs and PDEs. In each case the type of dynamical behavior being studied is motivated through applications, drawn from a wide variety of scientific disciplines ranging from theoretical physics to evolutionary biology. An extensive bibliography is provided.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 348 pp. Englisch.

  • Heinrich Freistühler

    Editore: Springer, Basel, Birkhäuser Basel, Birkhäuser Jan 2002, 2002

    ISBN 10: 3764367105 ISBN 13: 9783764367107

    Lingua: Inglese

    Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania

    Valutazione del venditore 5 su 5 stelle 5 stelle, Maggiori informazioni sulle valutazioni dei venditori

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    Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Hyperbolic partial differential equations describe phenomena of material or wave transport in physics, biology and engineering, especially in the field of fluid mechanics. The mathematical theory of hyperbolic equations has recently made considerable progress. Accurate and efficient numerical schemes for computation have been and are being further developed.This two-volume set of conference proceedings contains about 100 refereed and carefully selected papers. The books are intended for researchers and graduate students in mathematics, science and engineering interested in the most recent results in theory and practice of hyperbolic problems.Applications touched in these proceedings concern one-phase and multiphase fluid flow, phase transitions, shallow water dynamics, elasticity, extended thermodynamics, electromagnetism, classical and relativistic magnetohydrodynamics, cosmology. Contributions to the abstract theory of hyperbolic systems deal with viscous and relaxation approximations, front tracking and wellposedness, stability of shock profiles and multi-shock patterns, traveling fronts for transport equations. Numerically oriented articles study finite difference, finite volume, and finite element schemes, adaptive, multiresolution, and artificial dissipation methods. 472 pp. Englisch.

  • Egilius L.H. Spierings

    Editore: Springer, Basel, Birkhäuser Basel, Birkhäuser Jan 2002, 2002

    ISBN 10: 3764362316 ISBN 13: 9783764362317

    Lingua: Inglese

    Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania

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    Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The potential involvement of neurogenic inflammation in the pathogenesis of the migraine headache and the inhibition of this mechanism as a possible mode of action of antimigraine medications are discussed in great depth in this volume. The topics are approached from a pathophysiological as well as a clinical experimental perspective by a renowned group of clinicians and scientists who carefully consider the current, future, and potential therapeutic approaches to migraine treatment.The first chapters of the book address the impact of migraine on a personal and societal level, the presentation, pathogenesis and treatment of migraine as well as the role of neurogenic inflammation. Subsequent chapters present models of neurogenic inflammation related to the pathogenesis of the migraine headache, focussing on the mediators and their receptors, as well as on the involvement of mast cells. The possibility of inhibition of neurogenic inflammation in abortive and preventive migraine treatment is also extensively discussed and a chapter on the question of whether migraine is a neuroinflammatory disease concludes this comprehensive analysis.Clinicians and scientists interested in inflammation from a physiological or pharmacological perspective and those interested in the pathogenesis of headache - migraine in particular - are the intended audience for this unique body of work. 172 pp. Englisch.

  • Dalip J.S. Sirinathsinghji

    Editore: Springer, Basel, Birkhäuser Basel Jan 2002, 2002

    ISBN 10: 3764360119 ISBN 13: 9783764360115

    Lingua: Inglese

    Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania

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    Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Dalip J. S. Sirinathsinghii and Ray G. Hill Merck, Sharp & Dohme Research Laboratories, Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK There remains a distinct medical need for new pain therapies. Therefore, it is not surprising that in recent years there has been a major research initiative in both aca demic and pharmaceutical laboratories to identify novel pain targets and to devel op novel analgesic drugs. It is clear from numerous studies that the NMDA recep tor plays a major role in the transmission ofnociceptive information and it has been a subject of extensive investigation over the last decade exploiting the advances of molecular pharmacology and molecular neuroanatomy. As a consequence there has been a rational approach by several laboratories to develop receptor subtype-spe cific NMDA antagonists in order to avoid the wide range of side-effects seen with non-selective NMDA ion channel antagonists such as ketamine. This volume brings together contributions from experts in various technological disciplines who have contributed immensely to NMDA receptor research and advanced our understanding of the subunit composition of the NMDA receptor complex, its pharmacology and distribution, its interaction with other neurochemi cal systems and the effects on behaviour of NMDA antagonists in rodent models and in the clinic. In consideration of these advances and the prospects of novel NMDA receptor antagonists in the near future for the treatment of pain, this vol ume is very timely. 194 pp. Englisch.

  • Gerald Warnecke

    Editore: Birkhäuser Basel, Birkhäuser Basel Jan 2002, 2002

    ISBN 10: 3764367091 ISBN 13: 9783764367091

    Lingua: Inglese

    Da: buchversandmimpf2000, Emtmannsberg, BAYE, Germania

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    Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The Eighth International Conference on Hyperbolic Problems - Theory, Nu merics, Applications, was held in Magdeburg, Germany, from February 27 to March 3, 2000. It was attended by over 220 participants from many European countries as well as Brazil, Canada, China, Georgia, India, Israel, Japan, Taiwan, und the USA. There were 12 plenary lectures, 22 further invited talks, and around 150 con tributed talks in parallel sessions as well as posters. The speakers in the parallel sessions were invited to provide a poster in order to enhance the dissemination of information. Hyperbolic partial differential equations describe phenomena of material or wave transport in physics, biology and engineering, especially in the field of fluid mechanics. Despite considerable progress, the mathematical theory is still strug gling with fundamental open problems concerning systems of such equations in multiple space dimensions. For various applications the development of accurate and efficient numerical schemes for computation is of fundamental importance. Applications touched in these proceedings concern one-phase and multiphase fluid flow, phase transitions, shallow water dynamics, elasticity, extended ther modynamics, electromagnetism, classical and relativistic magnetohydrodynamics, cosmology. Contributions to the abstract theory of hyperbolic systems deal with viscous and relaxation approximations, front tracking and wellposedness, stability ofshock profiles and multi-shock patterns, traveling fronts for transport equations. Numerically oriented articles study finite difference, finite volume, and finite ele ment schemes, adaptive, multiresolution, and artificial dissipation methods. 496 pp. Englisch.

  • Giorgio Israel

    Editore: Springer, Basel, Birkhäuser Basel, Birkhäuser Jan 2002, 2002

    ISBN 10: 3764365145 ISBN 13: 9783764365141

    Lingua: Inglese

    Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania

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    Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Foreword The modern developments in mathematical biology took place roughly between 1920 and 1940, a period now referred to as the 'Golden Age of Theoretical Biology'. The eminent Italian mathematician Vito Volterra played a decisive and widely acknowledged role in these developments. Volterra's interest in the application of mathematics to the non physical sciences, and to biology and economics in particular, dates back to the turn of the century and was expressed in his inaugural address at the University of Rome for the academic year 1900/01 (VOLTERRA 1901). Nevertheless, it was only in the mid-twenties that Volterra entered the field in person, at the instigation of his son in law, Umberto D'Ancona, who had confronted him with the problem of competition among animal species, asking him whether a mathematical treatment was possible. From that time on, until his death in 1940, Volterra produced a huge output of publications on the subject. Volterra's specific project was to transfer the model and the concepts of classical mechanics to biology, constructing a sort of 'rational mechanics' and an 'analytic mechanics' of biological associations. The new subject was thus to be equipped with a solid experimental or at least empirical basis, also in this case following the tried and tested example of mathematical physics. Although very few specific features of this reductionist programme have actually survived, Volterra's contribution was decisive, as is now universally acknowledged, in en couraging fresh studies in the field of mathematical biology. 405 pp. Englisch.

  • Heinrich Freistühler

    Editore: Springer, Basel, Birkhäuser Basel, Birkhäuser Jan 2002, 2002

    ISBN 10: 3764367091 ISBN 13: 9783764367091

    Lingua: Inglese

    Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania

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    Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The Eighth International Conference on Hyperbolic Problems - Theory, Nu merics, Applications, was held in Magdeburg, Germany, from February 27 to March 3, 2000. It was attended by over 220 participants from many European countries as well as Brazil, Canada, China, Georgia, India, Israel, Japan, Taiwan, und the USA. There were 12 plenary lectures, 22 further invited talks, and around 150 con tributed talks in parallel sessions as well as posters. The speakers in the parallel sessions were invited to provide a poster in order to enhance the dissemination of information. Hyperbolic partial differential equations describe phenomena of material or wave transport in physics, biology and engineering, especially in the field of fluid mechanics. Despite considerable progress, the mathematical theory is still strug gling with fundamental open problems concerning systems of such equations in multiple space dimensions. For various applications the development of accurate and efficient numerical schemes for computation is of fundamental importance. Applications touched in these proceedings concern one-phase and multiphase fluid flow, phase transitions, shallow water dynamics, elasticity, extended ther modynamics, electromagnetism, classical and relativistic magnetohydrodynamics, cosmology. Contributions to the abstract theory of hyperbolic systems deal with viscous and relaxation approximations, front tracking and wellposedness, stability ofshock profiles and multi-shock patterns, traveling fronts for transport equations. Numerically oriented articles study finite difference, finite volume, and finite ele ment schemes, adaptive, multiresolution, and artificial dissipation methods. 474 pp. Englisch.

  • R. DeSalle

    Editore: Springer, Basel, Birkhäuser Basel, Birkhäuser Jan 2002, 2002

    ISBN 10: 3764365447 ISBN 13: 9783764365448

    Lingua: Inglese

    Da: BuchWeltWeit Ludwig Meier e.K., Bergisch Gladbach, Germania

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    EUR 11,00 per la spedizione da Germania a Italia

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    Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Important practical implications are established by case reports and specific examples. The present book is the ideal complement to the practitioner's manual Techniques in Molecular Systematics and Evolution, recently published by the same editors in the Birkhäuser MTBM book series.The first part of this book deals with important applications of evolutionary and systematic analysis at different taxonomic levels. The second part discusses DNA multiple sequence alignment, species designations using molecular data, evo-devo and other topics that are problematic or controversial. In the last part, novel topics in molecular evolution and systematics, like genomics, comparative methods in molecular evolution and the use of large data bases are described. The final chapter deals with problems in bacterial evolution, considering the increasing access to large numbers of complete genome sequences. 309 pp. Englisch.