birkhäuser basel nov 2003 (18 risultati)

Buch. Condizione: Neu. Neuware -M. LUCERTINI, A. MILLAN GASCA, AND F. NICOLO 1 Technology as Knowledge: The Case of Modern Engineering Systems In recent years scholars coming from the fields of history and philosophy of sci ence and technology have devoted much attention to the problem of 'technology as knowledge' and to the emergence of an autonomous engineering science in the Industrial Agel. This interest echoes a growing awareness among engineers of the independence of their conceptual approach with respect to other forms of knowl edge, linked to the consolidation of autonomous academic engineering research in th the 20 century. A careful examination of the nature of technological knowledge appears particularly valuable in view of the pervasive presence of technology in contemporary life and culture, not only as a result of its impressive achievements, but through the less obvious influence of its concepts and viewpoints as well. The activity of engineers and technicians has been traditionally based on the practical ability to cope with specific situations and to attain the corresponding specific goal by means of the design and realization of an artifact or structure, on the basis of past experience handed down by tradition and applied by means of trial-and-error and rule-of-thumb procedures. But the existence of a theoreti cal background and of principles underpinning this activity can be traced back to classical antiquity.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 268 pp. Englisch.

Taschenbuch. Condizione: Neu. Neuware -The book describes two stages in the historical development of the notion of mathematical structures: first, it traces its rise in the context of algebra from the mid-nineteenth century to its consolidation by 1930, and then it considers several attempts to formulate elaborate theories after 1930 aimed at elucidating, from a purely mathematical perspective, the precise meaning of this idea.First published in the series Science Networks Historical Studies, Vol. 17 (1996).In the second rev. edition the author has eliminated misprints, revised the chapter on Richard Dedekind, and updated the bibliographical index.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 472 pp. Englisch.

Buch. Condizione: Neu. Neuware -In July 1998, I received an e-mail from Alfred Gray, telling me: ' . . . I am in Bilbao and working on the second edition of Tubes . . . Tentatively, the new features of the book are: 1. Footnotes containing biographical information and portraits 2. A new chapter on mean-value theorems 3. A new appendix on plotting tubes ' That September he spent a week in Valencia, participating in a workshop on Differential Geometry and its Applications. Here he gave me a copy of the last version of Tubes. It could be considered a final version. There was only one point that we thought needed to be considered again, namely the possible completion of the material in Section 8. 8 on comparison theorems of surfaces with the now well-known results in arbitrary dimensions. But only one month later the sad and shocking news arrived from Bilbao: Alfred had passed away. I was subsequently charged with the task of preparing the final revision of the book for the publishers, although some special circumstances prevented me from finishing the task earlier. The book appears essentially as Alred Gray left it in September 1998. The only changes I carried out were the addition of Section 8. 9 (representing the discus sion we had), the inclusion of some new results on harmonic spaces, the structure of Hopf hypersurfaces in complex projective spaces and the conjecture about the volume of geodesic balls.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 300 pp. Englisch.

Buch. Condizione: Neu. Neuware -Arachidonic acid (AA) and other 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of inflammation known as eicosanoids. These mediators are critical in disease processes and in regulating normal cell function. Remodeling is important in maintaining homeostasis and in regulating cell function by dictating how PUFAs are converted to lipid mediators of inflammation. Thus, PUFA remodeling is a critical process in the biosynthesis of a multitude of mediators, and understanding this process will unravel better therapeutic targets for controlling inflammatory diseases such as asthma and Alzheimer¿s disease.AA metabolism is described in an integrated context linking the remodeling processes with the biosynthesis of mediators and diseases. By following the movement of the substrate (AA), the volume describes how upstream biosynthetic pathways influence the formation of lipid mediators of inflammation, showing the metabolic interrelationship between all AA-derived mediators.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 256 pp. Englisch.

Buch. Condizione: Neu. Neuware -The book consists of articles at the frontier of current research in Algebraic Topology. It presents recent results by top notch experts, and is intended primarily for researchers and graduate students working in the field of algebraic topology. Included is an important article by Cohen, Johnes and Yan on the homology of the space of smooth loops on a manifold M, endowed with the Chas-Sullivan intersection product, as well as an article by Goerss, Henn and Mahowald on stable homotopy groups of spheres, which uses the cutting edge technology of 'topological modular forms'.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 316 pp. Englisch.

Buch. Condizione: Neu. Neuware -In recent years, the area of pharmacotherapy of GI inflammation has witnessed important progress, with new drugs and therapeutic approaches being introduced. The volume reviews the pharmacotherapy of selected gastrointestinal inflammatory conditions chosen on the basis of their clinical importance and/or the areas where important and exciting progress has been made recently. Besides discussing current pharmacotherapy to treat the most important GI inflammation conditions, the book also indicates possible future therapeutic avenues likely to become available in a few years.The book is of interest to various sectors of the scientific community ranging from clinicians to pharmacologists and from biochemists to microbiologists, who will find it a useful tool for their clinical practice and research activity.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 160 pp. Englisch.

Buch. Condizione: Neu. Neuware -Many phenomena of interest for applications are represented by differential equations which are defined in a domain whose boundary is a priori unknown, and is accordingly named a 'free boundary'. A further quantitative condition is then provided in order to exclude indeterminacy. Free boundary problems thus encompass a broad spectrum which is represented in this state-of-the-art volume by a variety of contributions of researchers in mathematics and applied fields like physics, biology and material sciences. Special emphasis has been reserved for mathematical modelling and for the formulation of new problems.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 360 pp. Englisch.

Buch. Condizione: Neu. Neuware -The title High Dimensional Probability is an attempt to describe the many trib utaries of research on Gaussian processes and probability in Banach spaces that started in the early 1970's. In each of these fields it is necessary to consider large classes of stochastic processes under minimal conditions. There are rewards in re search of this sort. One can often gain deep insights, even about familiar processes, by stripping away details that in hindsight turn out to be extraneous. Many of the problems that motivated researchers in the 1970's were solved. But the powerful new tools created for their solution, such as randomization, isoperimetry, concentration of measure, moment and exponential inequalities, chaining, series representations and decoupling turned out to be applicable to other important areas of probability. They led to significant advances in the study of empirical processes and other topics in theoretical statistics and to a new ap proach to the study of aspects of Levy processes and Markov processes in general. Papers on these topics as well as on the continuing study of Gaussian processes and probability in Banach are included in this volume.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 360 pp. Englisch.

Buch. Condizione: Neu. Neuware -HIV infection has been a greater challenge to current medicine than any other viral disease ofmodem times. HIV leads to a persistent infection and the virus has an immense genetic flexibility under selective pressure. During its replica tive cycle in patients, HIV accumulates mutations at such a high rate that the selective pressure inflicted on the immune system, or generated by antiviral drugs rapidly triggers the appearance of escape mutants. Currently available drugs, when used singly, are not capable of suppressing virus replication in patients to such a level that the generation of mutations, from which a variant resistant to immune attack or antiviral drugs can be selected, is prevented. This is the main reason why combination therapy, usually of three drugs, has become the standard procedure for the treatment ofAIDS. It is obvious that virus eradication will not readily be achievable, so that drugs have to be taken for a prolonged time or even lifelong so as to keep the viral load as low as possible. Whether the currently used drug combinations will be able to control virus replication in a particular patient for such a pro longed period of time depends on many factors, most of which are addressed in the different chapters of this book. The aim of antiviral drug combination therapy for AIDS is ultimately to restore full function of the immune system.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 260 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This collection of historical research studies covers the evolution of technology as knowledge, the emergence of an autonomous engineering science in the Industrial Age, the idea of scientific managment of production and operation systems, and the interaction between mathematical models and technological concepts.The book is published with the support of the UNESCO Venice Office - Regional Office for Science & Technology in Europe as an activity of the Project: The evolution of events, concepts and models in engineering systems. 268 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The book describes two stages in the historical development of the notion of mathematical structures: first, it traces its rise in the context of algebra from the mid-nineteenth century to its consolidation by 1930, and then it considers several attempts to formulate elaborate theories after 1930 aimed at elucidating, from a purely mathematical perspective, the precise meaning of this idea.First published in the series Science Networks Historical Studies, Vol. 17 (1996).In the second rev. edition the author has eliminated misprints, revised the chapter on Richard Dedekind, and updated the bibliographical index. 452 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The book consists of articles at the frontier of current research in Algebraic Topology. It presents recent results by top notch experts, and is intended primarily for researchers and graduate students working in the field of algebraic topology. Included is an important article by Cohen, Johnes and Yan on the homology of the space of smooth loops on a manifold M, endowed with the Chas-Sullivan intersection product, as well as an article by Goerss, Henn and Mahowald on stable homotopy groups of spheres, which uses the cutting edge technology of 'topological modular forms'. 304 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Arachidonic acid (AA) and other 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of inflammation known as eicosanoids. These mediators are critical in disease processes and in regulating normal cell function. Remodeling is important in maintaining homeostasis and in regulating cell function by dictating how PUFAs are converted to lipid mediators of inflammation. Thus, PUFA remodeling is a critical process in the biosynthesis of a multitude of mediators, and understanding this process will unravel better therapeutic targets for controlling inflammatory diseases such as asthma and Alzheimer's disease.AA metabolism is described in an integrated context linking the remodeling processes with the biosynthesis of mediators and diseases. By following the movement of the substrate (AA), the volume describes how upstream biosynthetic pathways influence the formation of lipid mediators of inflammation, showing the metabolic interrelationship between all AA-derived mediators. 243 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In recent years, the area of pharmacotherapy of GI inflammation has witnessed important progress, with new drugs and therapeutic approaches being introduced. The volume reviews the pharmacotherapy of selected gastrointestinal inflammatory conditions chosen on the basis of their clinical importance and/or the areas where important and exciting progress has been maderecently. Besides discussing current pharmacotherapy to treat the most important GI inflammation conditions, the book also indicates possible future therapeutic avenues likely to become available in a few years.The book is of interest to various sectors of the scientific community ranging from clinicians to pharmacologists and from biochemists to microbiologists, who will find it a useful tool for their clinical practice and research activity. 146 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The title High Dimensional Probability is an attempt to describe the many trib utaries of research on Gaussian processes and probability in Banach spaces that started in the early 1970's. In each of these fields it is necessary to consider large classes of stochastic processes under minimal conditions. There are rewards in re search of this sort. One can often gain deep insights, even about familiar processes, by stripping away details that in hindsight turn out to be extraneous. Many of the problems that motivated researchers in the 1970's were solved. But the powerful new tools created for their solution, such as randomization, isoperimetry, concentration of measure, moment and exponential inequalities, chaining, series representations and decoupling turned out to be applicable to other important areas of probability. They led to significant advances in the study of empirical processes and other topics in theoretical statistics and to a new ap proach to the study of aspects of Levy processes and Markov processes in general. Papers on these topics as well as on the continuing study of Gaussian processes and probability in Banach are included in this volume. 346 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -In July 1998, I received an e-mail from Alfred Gray, telling me: ' . . . I am in Bilbao and working on the second edition of Tubes . . . Tentatively, the new features of the book are: 1. Footnotes containing biographical information and portraits 2. A new chapter on mean-value theorems 3. A new appendix on plotting tubes ' That September he spent a week in Valencia, participating in a workshop on Differential Geometry and its Applications. Here he gave me a copy of the last version of Tubes. It could be considered a final version. There was only one point that we thought needed to be considered again, namely the possible completion of the material in Section 8. 8 on comparison theorems of surfaces with the now well-known results in arbitrary dimensions. But only one month later the sad and shocking news arrived from Bilbao: Alfred had passed away. I was subsequently charged with the task of preparing the final revision of the book for the publishers, although some special circumstances prevented me from finishing the task earlier. The book appears essentially as Alred Gray left it in September 1998. The only changes I carried out were the addition of Section 8. 9 (representing the discus sion we had), the inclusion of some new results on harmonic spaces, the structure of Hopf hypersurfaces in complex projective spaces and the conjecture about the volume of geodesic balls. 280 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Many phenomena of interest for applications are represented by differential equations which are defined in a domain whose boundary is a priori unknown, and is accordingly named a 'free boundary'. A further quantitative condition is then provided in order to exclude indeterminacy. Free boundary problems thus encompass a broad spectrum which is represented in this state-of-the-art volume by a variety of contributions of researchers in mathematics and applied fields like physics, biology and material sciences. Special emphasis has been reserved for mathematical modelling and for the formulation of new problems. 347 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -HIV infection has been a greater challenge to current medicine than any other viral disease ofmodem times. HIV leads to a persistent infection and the virus has an immense genetic flexibility under selective pressure. During its replica tive cycle in patients, HIV accumulates mutations at such a high rate that the selective pressure inflicted on the immune system, or generated by antiviral drugs rapidly triggers the appearance of escape mutants. Currently available drugs, when used singly, are not capable of suppressing virus replication in patients to such a level that the generation of mutations, from which a variant resistant to immune attack or antiviral drugs can be selected, is prevented. This is the main reason why combination therapy, usually of three drugs, has become the standard procedure for the treatment ofAIDS. It is obvious that virus eradication will not readily be achievable, so that drugs have to be taken for a prolonged time or even lifelong so as to keep the viral load as low as possible. Whether the currently used drug combinations will be able to control virus replication in a particular patient for such a pro longed period of time depends on many factors, most of which are addressed in the different chapters of this book. The aim of antiviral drug combination therapy for AIDS is ultimately to restore full function of the immune system. 243 pp. Englisch.