birkhäuser basel springer basel nov 2004 (7 risultati)

Taschenbuch. Condizione: Neu. Neuware -Exciting developments in earthquake science have benefited from new observations, improved computational technologies, and improved modeling capabilities. Designing models of the earthquake generation process is a grand scientific challenge due to the complexity of phenomena and range of scales involved from microscopic to global. Such models provide powerful new tools for the study of earthquake precursory phenomena and the earthquake cycle.Through workshops, collaborations and publications, the APEC Cooperation for Earthquake Simulations (ACES) aims to develop realistic supercomputer simulation models for the complete earthquake generation process, thus providing a 'virtual laboratory' to probe earthquake behavior.Part II of the book embraces dynamic rupture and wave propagation, computational environment and algorithms, data assimilation and understanding, and applications of models to earthquakes. This part also contains articles on the computational approaches and challenges of constructing earthquake models.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 356 pp. Englisch.

Buch. Condizione: Neu. Neuware - Is it advisable to go back from bedside to the bench During the last decade, few topics encountered such a broad interest in bio- gy and medicine as angiogenesis. The amazing ability of the body to restore blood flow by induction of blood vessel growth as part of an adaptive process has alarmed physicians dealing with diseases in which angiogenesis is either exaggerated (as in tumors) or too slow (as in ischemic diseases of heart and brain). Not surprisingly, pro- and antiangiogenic strategies have found their way into clinical trials. For instance, for the USA, the NIH website in early 2004 displayed 38 clinical studies involving either pro- or antiangiogenic th- apies. Given the expected overwhelming wealth of clinical data, the question may be asked whether further exploration of biological mechanisms is required or whether results from the bedside are instructive enough to proceed. This question depends also on the progress of pro- and antiangiogenic clinical trials. In the following, I give a short overview about some of the progress that has been made in this field. Since Judah Folkman proposed antiangiogenic tumor therapy thirty years ago, it has become increasingly evident that agents which interfere with blood vessel formation also block tumor progression. Accordingly, antiangiogenic therapy has gained much attention as a potential adjunct to conventional c- cer therapy.

Buch. Condizione: Neu. Neuware -Der Autor informiert über die unterschiedlichen Bestimmungen in den Landesbauordnungen, Normen und Gesetzen sowie über die brandtechnischen Eigenschaften von Baustoffen und Bauteilen. Neben den Anforderungen für den Wohnungsbau werden auch die Bestimmungen für den Industrie- und Sonderbau sowie die Möglichkeiten und Probleme bei der Sanierung von Gebäuden behandelt.Springer Basel AG in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 360 pp. Deutsch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Exciting developments in earthquake science have benefited from new observations, improved computational technologies, and improved modeling capabilities. Designing models of the earthquake generation process is a grand scientific challenge due to the complexity of phenomena and range of scales involved from microscopic to global. Such models provide powerful new tools for the study of earthquake precursory phenomena and the earthquake cycle.Through workshops, collaborations and publications, the APEC Cooperation for Earthquake Simulations (ACES) aims to develop realistic supercomputer simulation models for the complete earthquake generation process, thus providing a 'virtual laboratory' to probe earthquake behavior.Part II of the book embraces dynamic rupture and wave propagation, computational environment and algorithms, data assimilation and understanding, and applications of models to earthquakes. This part also contains articles on the computational approaches and challenges of constructing earthquake models. 348 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Prion diseases, also known as Transmissible Spongiform Encephalopathies (TSEs), exist in both humans (Creutzfeldt-Jakob disease (CJD)) and animals (scrapie, bovine spongiform encephalopathy (BSE), chronic wasting disease) and have the unique property of being infectious, sporadic or genetic in origin.Although the precise nature of the infectious agent responsible for TSEs is not definitely identified, it is now clearly demonstrated that a protein named PrP (for Prion Protein) plays a critical role in the transmission and pathogenesis of TSEs.This book provides the general description as well as the details of the techniques currently used for the study of prion diseases. Taking into account the pivotal role played by PrP it is not surprising that many Chapters of this book deal with the purification, the detection and the characterization of the different forms of this protein. In addition, in vitro, cellular and animal models specifically adapted to the study of TSEs, as well as bio-safety procedures are described. Each Chapter is written by scientists involved for many years in their respective domain of prion biology who give the best of their knowledge in this technical document. This volume is a very useful tool for any laboratory which recently decided to contribute to the study of TSEs as well as for teams already engaged in this field for many years but interested in extending their technical capacity toward new methods.Features:Purification of PrPC and the Pathological Isoform of Prion Protein (PrPsc or PrP-res)Animal Models of TSEsCell Culture Models of TSEsPrPsc ImmunohistochemistryWestern Immunoblotting TechniquesAntibody Production and ELISATSE Strain Typing in MiceBiosafety and Decontamination ProceduresCell-free Conversion of Prion ProteinsCytotoxicity of PrP PeptidesCyclic Amplification of Prion Protein MisfoldingOf interest to:Researchers and clinicians in the fields of cell biology, biomedicine, neuroscience/neuropathology, veterinary medicine and biochemistry. 221 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Although the potential for immunomodulation has been recognized for many years there has been an explosion of data in this field with relevance especially to the treatment of chronic airway diseases. Most of the work in this field has been conducted by Japanese investigators but in the last decade there has been a body of work outside of Japan that supports and enhances these findings. The book covers basic research like effects on bacteria, anti-inflammatory and mucoregulatory effects, but also clinical results with up-to-date information for the use of such medications to potentially treat diseases as diverse as chronic airway diseases, arthritis, inflammatory bowel disease, and cancer. The volume is intended for pulmonary physicians, researchers in inflammation research, and pharmaceutical companies interested in the development of such agents. It provides background information for the clinician as well as in depth exploration of cutting edge science. 276 pp. Englisch.

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Unter dem Begriff des Bautechnischen Brandschutzes werden Maßnahmen und Forderungen an Baustoffe, Bauteile und technische Einrichtungen zusammengefasst, die eine Brandentstehung vorbeugen, die Ausbreitung des Feuers im Schadensfall verhindern und eine wirksame Brandbekämpfung ermöglichen. Der Autor informiert über die unterschiedlichen Bestimmungen in den Landesbauordnungen, Normen und Gesetzen sowie über die brandtechnischen Eigenschaften von Baustoffen und Bauteilen. Neben den Anforderungen für den Wohnungsbau werden auch die Bestimmungen für den Industrie- und Sonderbau sowie die Möglichkeiten und Probleme bei der Sanierung von Gebäuden behandelt. Das Buch hilft, den Architekten und den Ingenieur in den Anforderungen der Bauordnung und des Baulichen Brandschutzes zu schulen und ihn zu befähigen, die notwendigen Maßnahmen frühzeitig im Bauvorhaben einzuplanen und durch qualifizierte Planungsschritte kostengünstig sicherzustellen. 360 pp. Deutsch.