crc press jan 2023 (64 risultati)

Taschenbuch. Condizione: Neu. Neuware - Focusing on the modeling, analysis, and management of risk in today's complex engineering enterprise systems, this book provides advanced methods for tackling risk problems at the enterprise level. The text presents a risk analytical framework for engineering enterprise systems and covers capability portfolio risk management, functional dependen.

Taschenbuch. Condizione: Neu. Neuware - The text presents modeling topics using Maple as the computer algebra system for solving mathematical equations as well as obtaining plots that help us perform our analyses. It presents cogent applications of applied mathematics, provides discussions of the results obtained, and stimulate thought and analysis of additional applications.

Taschenbuch. Condizione: Neu. Neuware - This second edition is updated with regard to recent technological advances and regulatory changes since 2012. It covers the latest environmental issues, including emerging contaminants, a new chapter on Brownfields Redevelopment has been added. Problems and questions for homework assignments or classroom discussions are included in each chapter.

Taschenbuch. Condizione: Neu. Neuware - The Second Edition of this successful text is unique in its approach to motivation, precision, explanations and methods. Topics are introduced in a more accessible way then subsequent sections develop these further. Motivating the concepts, modeling, and technology are emphasized. An engaging writing style appeals to students.

Taschenbuch. Condizione: Neu. Neuware - For students, researchers and professionals probing microbial interactions with living organisms, this book provides a fundamental understanding of the importance of the microbiome in the life of multicellular organisms. It explains why microbes are an integral part of organisms and describes the diverse roles they perform for their hosts.

Taschenbuch. Condizione: Neu. Neuware - This unique and comprehensive atlas by an expert practioner provides an innovative pictorial guide to flexible bronchoscopy, one of the most exciting and challenging procedures in respiratory medicine today.

Buch. Condizione: Neu. Neuware - Oribatid mites, also called beetle or moss mites, include more than 10,000 named species representing 172 families worldwide. This book provides an identification key to the 96 families, 250 genera and the c.580 described species for Canada and Alaska, a fauna that encompasses more than 50% of northern Hemisphere genera.

Buch. Condizione: Neu. Neuware - This book takes an interdisciplinary approach to contribute to the ongoing development of human-AI interaction with a particular focus on the 'human' dimension and provides insights to improve the design of AI that could be genuinely beneficial and effectively used in society.

Buch. Condizione: Neu. Neuware - Frontiers of Civil Engineering and Disaster Prevention and Control is a compilation of selected papers from The 3rd International Conference on Civil, Architecture and Disaster Prevention and Control (CADPC 2022) and focuses on the research of architecture and disaster prevention in civil engineering. The proceedings features the most cutting-edge research directions and achievements related to construction technology and prevention and control of disaster. Subjects in this proceedings include:

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -This book provides a step-by-step guide on how to use various publicly available remotely sensed time series data sources for environmental monitoring and assessment. Readers will learn how to extract valuable information on global changes from a 20-year collection of ready-to-use remotely sensed data through the free open statistical software R and its geographic data analysis and modeling tools. The case studies are from the Mediterranean region-a designated hot spot regarding climate change effects. Each chapter is dedicated to specific remote sensing products chosen for their spatial resolution. The methods used are adapted from large-scale to smaller-scale problems for different land cover areas.FeaturesIncludes real-world applications of environmental remotely sensed dataAnalyzes the advantages and restrictions of each data sourceFocuses on a wide spectrum of applications, such as hydrology, vegetation changes, land surface temperature, fire detection, and impactsIncludes R computer codes with explanatory comments and all applications use only freely available remotely sensed dataPresents a step-by-step processing through open source GIS and statistical analysis softwareAdvanced Environmental Monitoring with Remote Sensing Time Series Data and R describes and provides details on recent advances concerning publicly available remotely sensed time series data in environmental monitoring and assessment. This book is a must-have practical guide for environmental researchers, professionals, and students. 114 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Praise for the First Edition:'A real, combined approach of behavioural, social, biomedical, and clinical sciences is paramount. [This book] is one pioneering example of such integration, bridging core sociology with medical education.'- Dikomitis L, Wenning B, Ghobrial A, and Adams K.M. (2022). Embedding behavioural and social sciences across the medical curriculum: (Auto) ethnographic insights from medical schools in the United Kingdom. Societies, 12, 101. 'Constantinou's book not only contributes to bridging the gap between theoretical sociology and medical education, it also contributes to the way we teach a new generation of students - how to understand patients in context, how to treat them with respect and, ultimately, how to be a better medical doctor.'- Andrea Stockl from her Foreword to the First EditionComments from Medical Students:''Ignorance is not just lack of knowledge but lack of implementing knowledge gained'. I encourage everybody going into a clinical and general work setting to read this book and implement.''I believe this book is the key to unlocking the minds of medical students in viewing illness as not only physical and emotional also as social experience.''I believe everyone should read this book, especially medical students and practitioners who wish to become all-round competent and understanding doctors.' 'The better you understand your patient's illness and his/her suffering, the healthier you can make him/her - this book teaches this important skill.' This popular and accessible text continues to cover the basic principles of the sociology of health and illness in an eminently readable way. This fully revised second edition has been inspired, informed, and reviewed by medical students. By creatively employing a problem-based learning approach, the book examines commonly covered topics integrating underlying principles and research findings through real-life stories. The book investigates the relevance of sociology and considers a new direction - one that places sociology in the context of healthcare settings, making the topic more realistic, useful, and memorable. The book will be an invaluable companion for medical students throughout undergraduate studies and is also a useful reference for students in nursing, social work, psychology, and sociology, as well as qualified doctors and healthcare practitioners. 212 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -With the increasing demand of robots for industrial and domestic use, it becomes indispensable to ensure their safety, security, and reliability. Safety, Security and Reliability of Robotic Systems: Algorithms, Applications, and Technologies provides a broad and comprehensive coverage of the evolution of robotic systems, as well as industrial statistics and future forecasts. First, it analyzes the safety-related parameters of these systems. Then, it covers security attacks and related countermeasures, and how to establish reliability in these systems. The later sections of the book then discuss various applications of these systems in modern industrial and domestic settings. By the end of this book, you will be familiarized with the theoretical frameworks, algorithms, applications, technologies, and empirical research findings on the safety, security, and reliability of robotic systems, while the book's modular structure and comprehensive material will keep you interested and involved throughout. This book is an essential resource for students, professionals, and entrepreneurs who wish to understand the safe, secure, and reliable use of robotics in real-world applications. It is edited by two specialists in the field, with chapter contributions from an array of experts on robotics systems and applications. 278 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Internet of Things (IoT)-enabled spaces have made revolutionary advances in the utility grid. Among these advances, intelligent and energy-efficient services are gaining considerable interest. The use of the smart grid is increasing day after day around us and is not only used in saving energy but also in our daily life for intelligent health, traffic, and even farming systems. The grid enabled with IoT features is also expected to communicate with cellular networks smoothly in the next-generation networks (6G and beyond). This will open the door for other interesting research areas. In this book, we consider the most significant and emergent research topics in this domain, addressing major issues and challenges in IoT-based solutions proposed for the smart grid. The chapters provide insight on comprehensive topics in IoT-based smart grids, combining technical aspects with the most up-to-date theory. It investigates the grid under varying and potential emerging paradigms such as edge/fog computing, in addition to big data aspects considerations in the IoT era. With comprehensive surveys and case studies, this book explores basic and high-level grid aspects in the emerging smart city paradigm, which makes it especially attractive to researchers, academics, and higher-level students. This authored book can be used by computer science undergraduate and postgraduate students, researchers and practitioners, city administrators, policymakers, and government regulators. 298 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -ERP Systems for Manufacturing Supply Chains: Applications, Configuration, and Performance provides insight into the core architecture, modules, and process support of ERP systems used in a manufacturing supply chain. This book explains the building blocks of an ERP system and how they can be used to increase performance of manufacturing supply chains.Starting with an overview of basic concepts of supply chain and ERP systems, the book delves into the core ERP modules that support manufacturing facilities and organizations. It examines each module's structure and functionality as well as the process support the module provides. Cases illustrate how the modules can be applied in manufacturing environments. Also covered is how the ERP modules can be configured to support manufacturing supply chains. Setting up an ERP system to support the supply chain within single manufacturing facility provides insight into how an ERP system is used in the smallest of manufacturing enterprises, as well as lays the foundation for ERP systems in manufacturing organizations. The book then supplies strategies for larger manufacturing enterprises and discusses how ERP systems can be used to support a complete manufacturing supply chain across different facilities and companies.The ERP systems on the market today tend to use common terminology and naming for describing specific functions and data units in the software. However, there are differences among packages. The book discusses various data and functionalities found in different ERP-software packages and uses generic and descriptive terms as often as possible to make these valid for as many ERP systems as possible.Filled with insight into ERP system's core modules and functions, this book shows how ERP systems can be applied to support a supply chain in the smallest of manufacturing organizations that only consist of a single manufacturing facility, as well as large enterprises where the manufacturing supply chain crosses multiple facilities and companies. 242 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -With more than three decades of experience as a thought-leader and expert practitioner, PMI Fellow Dr. David Hillson shares practical insight into howupside risks can be identified, assessed, and managed asopportunities. After reviewing the benefits of identifying opportunities, the book steps through the opportunity identification and management process in detail, describing proven tools and techniques as well as specific tips to make them work in practice. The book places opportunity management in the context of traditional risk management, providinga familiarpathway that leadsproject managers to discover new benefits and successes.David Hillson is one of the foremost authorities on risk management. With his latest book he presents a strong case for managing opportunities. As with all of David's books, the style of writing is engaging and easy to understand. There are many nuggets of wisdom in this book, as well as a hands-on approach to leveraging opportunity management as a way of improving project performance. - Cyndi Snyder Dionisio, PMI Fellow, Coronado CA, USA. (Chair of the PMBOK®Guide, Sixth Edition) I enjoyed reading this book, which is precise, clear, logical, and persuasive. The clarity of thought and expression explains why David is such a sought-after speaker. This book is a must-read for project risk practitioners, as well as for project professionals who are serious about addressing all the risks on their project, including the good ones. - Dr Dale Cooper, Cammeray NSW, Australia. (Director, Broadleaf Capital International)At last, a clear and valuable book linking both sides of the coin in risk management: threats and opportunities. David Hillson truly engages the reader on how to deal with these two types of risk in projects, sharing his wisdom and extensive experience in creating value from risk management. Anyone who has to manage risk in real-world projects should read this book to enhance their opportunity management skills. - Professor Salim Al-Harthi, Muscat, Oman. (Director of Risk Management Office, Sultan Qaboos University) It is vital for value creation in business and in life that we consider uncertainties that would have upside impacts on our objectives (opportunities), as well as downside impacts (threats). Business gets confused between opportunities where there is a binary choice to take or not, and true uncertain opportunities that can be seized, or left to chance. David has persevered in helping us understand this and this important book is a must-read for all leaders who want to create value through the proactive management of risk. - Dr Ruth Murray-Webster, Wakefield, UK. (Partner, Beyond the Deal LLP and Editor, APM Body of Knowledge, 7th Edition)As project managers, we always seem to focus on threats, negative risks. David Hillson, one of the foremost thought-leaders on risk management, explains approaches to identify and manage opportunities, positive risks and how this will help achieve project success. As with his previous books, David provides a structured approach with examples, tools, and techniques. An excellent resource for all project managers in today's world. - Peter Monkhouse, Toronto ON, Canada. (Past Chair PMI Board of Directors) 300 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Based on the technical accumulation and practice of Huawei iLab in the Cloud VR field, this book systematically describes the advantages of Cloud VR technologies; technical requirements on clouds, networks, and terminals as well as solution implementation; Cloud VR experience evaluation baselines and methods; and current business practices. Cloud VR introduces cloud computing and cloud rendering to VR services. With fast and stable networks, cloud-based display output and audio output are coded, compressed, and transmitted to user terminals, implementing cloud-based VR service content and content rendering. Cloud VR has stringent requirements on bandwidth and latency, making it a proficient application for 5G and gigabit home broadband networks in the era of 'dual G'. As the first advocate of Cloud VR, Huawei iLab developed the first prototype of the Cloud VR technical solution, initiated the industry's first Cloud VR industry cooperation plan - VR OpenLab with partners - and incubated the world's first Cloud VR commercial project with China Mobile Fujian. Cloud VR: Technology and Application is the first official publication of Huawei iLab's research and practice achievements. It systematically and thoroughly introduces the Cloud VR concept, solution architecture, key technologies, and business practices and is of great value in academic and social applications.This book is easy to understand, practical, and suitable for VR vendors, VR technology enthusiasts, carriers, network vendors, cloud service providers, universities, and other enterprisesand scientific research institutes. 260 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Preeminent Experts Update a Well-Respected BookTaking into account the regulatory and scientific developments that have occurred since the second edition, Design and Analysis of Bioavailability and Bioequivalence Studies, Third Edition provides a complete presentation of the latest progress of activities and results in bioavailability and bioequivalence on regulatory requirements, scientific and practical issues, and statistical methodology.New to the Third EditionFour new chapters that present a thorough account of novel developments in the fieldNew and updated sections that reflect recent advances in the statistical methodology in the design and analysis of bioavailability and bioequivalence studiesReorganization of the material into five parts, making it easier to access related information togetherOver 100 new references from the literatureLike its bestselling predecessors, this edition covers all of the statistical problems that may occur in the various stages of design and data analysis. Keeping the mathematics and statistics at a fundamental level, it continues to focus on practical concepts rather than technical details. 756 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Multiple Comparisons introduces simultaneous statistical inference and covers the theory and techniques for all-pairwise comparisons, multiple comparisons with the best, and multiple comparisons with a control. The author describes confidence intervals methods and stepwise exposes abuses and misconceptions, and guides readers to the correct method for each problem. Discussions also include the connections with bioequivalence, drug stability, and toxicity studies Real data sets analyzed by computer software packages illustrate the applications presented. 292 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Combinatorics and Number Theory of Counting Sequences is an introduction to the theory of finite set partitions and to the enumeration of cycle decompositions of permutations.The presentation prioritizes elementary enumerative proofs. Therefore, parts of the book are designed so that even those high school students and teachers who are interested in combinatorics can have the benefit of them. Still, the book collects vast, up-to-date information for many counting sequences (especially, related to set partitions and permutations), so it is a must-have piece for those mathematicians who do research on enumerative combinatorics.In addition, the book contains number theoretical results on counting sequences of set partitions and permutations, so number theorists who would like to see nice applications of their area of interest in combinatorics will enjoy the book, too.FeaturesThe Outlook sections at the end of each chapter guide the reader towards topics not covered in the book, and many of the Outlook items point towards new research problems.An extensive bibliography and tables at the end make the book usable as a standard reference.Citations to results which were scattered in the literature now become easy, because huge parts of the book (especially in parts II and III) appear in book form for the first time. 498 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -The get-it-over-with-quickly approach to statistics has been encouraged - and often necessitated - by the short time allotted to it in most curriculums. If included at all, statistics is presented briefly, as a task to be endured mainly because pertinent questions may appear in subsequent examinations for licensure or other certifications. However, in later professional activities, clinicians and biomedical researchers will constantly be confronted with reports containing statistical expressions and analyses.Not just a set of cookbook recipes, Principles of Medical Statistics is designed to get you thinking about data and statistical procedures. It covers many new statistical methods and approaches like box plots, stem and leaf plots, concepts of stability, the bootstrap, and the jackknife methods of resampling. The book is arranged in a logical sequence that advances from simple to more elaborate results. The text describes all the conventional statistical procedures, and offers reasonably rigorous accounts of many of their mathematical justifications. Although the conventional mathematical principles are given a respectful account, the book provides a distinctly clinical orientation with examples and teaching exercises drawn from real world medical phenomena.Statistical procedures are an integral part of the basic background needed by biomedical researchers, students, and clinicians. Containing much more than most elementary texts, Principles of Medical Statistics fills the gap often found in the current curriculum. It repairs the imbalance that gives so little attention to the role of statistics as a prime component of basic biomedical education. 712 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Item Response Theory clearly describes the most recently developed IRT models and furnishes detailed explanations of algorithms that can be used to estimate the item or ability parameters under various IRT models. Extensively revised and expanded, this edition offers three new chapters discussing parameter estimation with multiple groups, parameter estimation for a test with mixed item types, and Markov chain Monte Carlo methods. It includes discussions on issues related to statistical theory, numerical methods, and the mechanics of computer programs for parameter estimation, which help to build a clear understanding of the computational demands and challenges of IRT estimation procedures. 524 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Offering a unique balance between applications and calculations, Monte Carlo Methods and Models in Finance and Insurance incorporates the application background of finance and insurance with the theory and applications of Monte Carlo methods. It presents recent methods and algorithms, including the multilevel Monte Carlo method, the statistical Romberg method, and the Heath-Platen estimator, as well as recent financial and actuarial models, such as the Cheyette and dynamic mortality models.The authors separately discuss Monte Carlo techniques, stochastic process basics, and the theoretical background and intuition behind financial and actuarial mathematics, before bringing the topics together to apply the Monte Carlo methods to areas of finance and insurance. This allows for the easy identification of standard Monte Carlo tools and for a detailed focus on the main principles of financial and insurance mathematics. The book describes high-level Monte Carlo methods for standard simulation and the simulation of stochastic processes with continuous and discontinuous paths. It also covers a wide selection of popular models in finance and insurance, from Black-Scholes to stochastic volatility to interest rate to dynamic mortality.Through its many numerical and graphical illustrations and simple, insightful examples, this book provides a deep understanding of the scope of Monte Carlo methods and their use in various financial situations. The intuitive presentation encourages readers to implement and further develop the simulation methods. 484 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Using the same accessible, hands-on approach as its best-selling predecessor, the Handbook of Univariate and Multivariate Data Analysis with IBM SPSS, Second Edition explains how to apply statistical tests to experimental findings, identify the assumptions underlying the tests, and interpret the findings. This second edition now covers more topics and has been updated with the SPSS statistical package for Windows.New to the Second EditionThree new chapters on multiple discriminant analysis, logistic regression, and canonical correlationNew section on how to deal with missing dataCoverage of tests of assumptions, such as linearity, outliers, normality, homogeneity of variance-covariance matrices, and multicollinearityDiscussions of the calculation of Type I error and the procedure for testing statistical significance between two correlation coefficients obtained from two samples Expanded coverage of factor analysis, path analysis (test of the mediation hypothesis), and structural equation modelingSuitable for both newcomers and seasoned researchers in the social sciences, the handbook offers a clear guide to selecting the right statistical test, executing a wide range of univariate and multivariate statistical tests via the Windows and syntax methods, and interpreting the output results. The SPSS syntax files used for executing the statistical tests can be found in the appendix. Data sets employed in the examples are available on the book's CRC Press web page. 586 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -SinceROC curves have become ubiquitous in many application areas, the various advances have been scattered across disparate articles and texts. ROC Curves for Continuous Data is the first book solely devoted to the subject, bringing together all the relevant material to provide a clear understanding of how to analyze ROC curves.The fundamental theory of ROC curvesThe book first discusses the relationship between the ROC curve and numerous performance measures and then extends the theory into practice by describing how ROC curves are estimated. Further building on the theory, the authors present statistical tests for ROC curves and their summary statistics. They consider the impact of covariates on ROC curves, examine the important special problem of comparing two ROC curves, and cover Bayesian methods for ROC analysis. Special topicsThe text then moves on to extensions of the basic analysis to cope with more complex situations, such as the combination of multiple ROC curves and problems induced by the presence of more than two classes. Focusing on design and interpretation issues, it covers missing data, verification bias, sample size determination, the design of ROC studies, and the choice of optimum threshold from the ROC curve. The final chapter explores applications that not only illustrate some of the techniques but also demonstrate the very wide applicability of these techniques across different disciplines.With nearly 5,000 articles published to date relating to ROC analysis, the explosive interest in ROC curves and their analysis will continue in the foreseeable future. Embracing this growth of interest, this timely book will undoubtedly guide present and future users of ROC analysis. 256 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Fifteen years have passed since the 3rd edition of Antimicrobials in Food was published. It was arguably considered the 'must-have' reference for those needing information on chemical antimicrobials used in foods. In the years since the last edition, the food industry has undergone radical transformations because of changes on several fronts. Reported consumer demands for the use of 'natural' and 'clean-label' antimicrobials have increased significantly. The discovery of new foodborne pathogen niches and potentially hazardous foods, along with a critical need to reduce food spoilage waste, has increased the need for suitable antimicrobial compounds or systems. Novel natural antimicrobials continue to be discovered, and new research has been carried out on traditional compounds. These and other related issues led the editors to develop the 4th edition of Antimicrobials in Food.In the 4th edition, the editors have compiled contemporary topics with information synthesized from internationally recognized authorities in their fields. In addition to updated information, new chapters have been added in this latest release with content on the use of bacteriophages, lauric arginate ester, and various systems for antimicrobial encapsulation and delivery. Comprehensive revisions of landmark chapters in previous editions including naturally occurring antimicrobials from both animal and plant sources, methods for determining antimicrobial activity, new approaches to multifactorial food preservation or 'hurdle technology,' and mechanisms of action, resistance, and stress adaptation are included. Complementing these topics is new information on quantifying the capability of 'clean' antimicrobials for food preservation when compared to traditional food preservatives and industry considerations when antimicrobials are evaluated for use in food manufacture.FeaturesCovers all food antimicrobials, natural and synthetic, with the latest research on each typeContains 5,000+ references on every conceivable food antimicrobialGuides in the selection of appropriate additives for specific food productsIncludes innovations in antimicrobial delivery technologies and the use of multifactorial food preservation with antimicrobials 828 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Novel Statistical Tools for Conserving and Managing PopulationsBy gathering information on key demographic parameters, scientists can often predict how populations will develop in the future and relate these parameters to external influences, such as global warming. Because of their ability to easily incorporate random effects, fit state-space models, evaluate posterior model probabilities, and deal with missing data, modern Bayesian methods have become important in this area of statistical inference and forecasting. Emphasising model choice and model averaging, Bayesian Analysis for Population Ecology presents up-to-date methods for analysing complex ecological data. Leaders in the statistical ecology field, the authors apply the theory to a wide range of actual case studies and illustrate the methods using WinBUGS and R. The computer programs and full details of the data sets are available on the book's website.The first part of the book focuses on models and their corresponding likelihood functions. The authors examine classical methods of inference for estimating model parameters, including maximum-likelihood estimates of parameters using numerical optimisation algorithms. After building this foundation, the authors develop the Bayesian approach for fitting models to data. They also compare Bayesian and traditional approaches to model fitting and inference.Exploring challenging problems in population ecology, this book shows how to use the latest Bayesian methods to analyse data. It enables readers to apply the methods to their own problems with confidence. 456 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Useful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple comparison research with an emphasis on pharmaceutical applications. In each chapter, the expert contributors describe important multiplicity problems encountered in pre-clinical and clinical trial settings. The book begins with a broad introduction from a regulatory perspective to different types of multiplicity problems that commonly arise in confirmatory controlled clinical trials, before giving an overview of the concepts, principles, and procedures of multiple testing. It then presents statistical methods for analyzing clinical dose response studies that compare several dose levels with a control as well as statistical methods for analyzing multiple endpoints in clinical trials. After covering gatekeeping procedures for testing hierarchically ordered hypotheses, the book discusses statistical approaches for the design and analysis of adaptive designs and related confirmatory hypothesis testing problems. The final chapter focuses on the design of pharmacogenomic studies based on established statistical principles. It also describes the analysis of data collected in these studies, taking into account the numerous multiplicity issues that occur.This volume explains how to solve critical issues in multiple testing encountered in pre-clinical and clinical trial applications. It presents the necessary statistical methodology, along with examples and software code to show how to use the methods in practice. 322 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware 492 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Over the last 20 years, comprehensive strategies for treating measurement error in complex models and accounting for the use of extra data to estimate measurement error parameters have emerged. Focusing on both established and novel approaches, Measurement Error: Models, Methods, and Applications provides an overview of the main techniques and illustrates their application in various models. It describes the impacts of measurement errors on naive analyses that ignore them and presents ways to correct for them across a variety of statistical models, from simple one-sample problems to regression models to more complex mixed and time series models.The book covers correction methods based on known measurement error parameters, replication, internal or external validation data, and, for some models, instrumental variables. It emphasizes the use of several relatively simple methods, moment corrections, regression calibration, simulation extrapolation (SIMEX), modified estimating equation methods, and likelihood techniques. The author uses SAS-IML and Stata to implement many of the techniques in the examples.Accessible to a broad audience, this book explains how to model measurement error, the effects of ignoring it, and how to correct for it. More applied than most books on measurement error, it describes basic models and methods, their uses in a range of application areas, and the associated terminology. 464 pp. Englisch.

Taschenbuch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Interpreting statistical data as evidence, Statistical Evidence: A Likelihood Paradigm focuses on the law of likelihood, fundamental to solving many of the problems associated with interpreting data in this way. Statistics has long neglected this principle, resulting in a seriously defective methodology. This book redresses the balance, explaining why science has clung to a defective methodology despite its well-known defects. After examining the strengths and weaknesses of the work of Neyman and Pearson and the Fisher paradigm, the author proposes an alternative paradigm which provides, in the law of likelihood, the explicit concept of evidence missing from the other paradigms. At the same time, this new paradigm retains the elements of objective measurement and control of the frequency of misleading results, features which made the old paradigms so important to science. The likelihood paradigm leads to statistical methods that have a compelling rationale and an elegant simplicity, no longer forcing the reader to choose between frequentist and Bayesian statistics. 208 pp. Englisch.