Humana apr 2003 (23 risultati)

Buch. Condizione: Neu. Neuware - Exciting new 'biologic' therapies for treating leukemia are appearing so rapidly that clinicians often find it difficult to make informed decisions about their use when making patient treatment decisions. In Biologic Therapy of Leukemia, distinguished physicians and medical researchers summarize and review all the available data concerning these cutting-edge biologic therapies so that practicing clinicians can make correct patient-care choices. Here the busy physician will find, in one convenient place, crucial information on the uses and limitations of the major biologic therapies for leukemia, the different biologic strategies for its treatment, the management of patients being treated with such biologic agents, and the current and future role of emerging biologic agents. Well-established therapies, such as interferon and all-trans-retinoic acid, are included so that their efficacy can be contrasted with such newer agents as imatinib mesylate and arsenic trioxide. P-glycoprotein inhibitors, interleukins, and the graft-vs-leukemia effect are also examined, along with approaches that reverse failure of apoptosis, alter genetic codes, and modulate immunologic mechanisms. Authoritative and readily accessible, Biologic Therapy of Leukemia provides today's practicing oncologists with a comprehensive review of all currently available biologic approaches and agents, as well as the many different subtypes of leukemia, affording expert guidance in choosing optimal therapies for each patient.…

Buch. Condizione: Neu. Neuware - Most endocrine diseases can be treated successfully, and the patient's state of well-being can usually be improved. Not surprisingly, the earlier the diagnosis is made the more positive the clinical response. Early Diagnosis and Treatment (~f Endocrine Disorders focuses on early signs and symptoms of endocrine disorders and surveys the appropriate tests to document the diseases as well as current recommendations for therapy. Each chapterreviews the pathophysiology of the endocrine disease-important for understanding each disorder as well as the rationale for early therapy-and the basis for the early recognition and treatment of each condition. Although the practicing endocrinologist is likely to be quite knowledgeable regarding many of these diseases, Early Diagnosis and Treatment of Endocrine Disorders includes treatment of those conditions only recently classified as endocrine disorders, such as polycystic ovarian syndrome, obesity, and hypogonadism. The book also provides new approaches that are urgently needed to slow the epidemic of type 2 diabetes, which should be an overriding concern for all clinicians. Until now, no other endocrinology text has focused primarily on the details of early recognition and therapy of endocrine disorders. The information in Early Diagnosis and Treatment of Endocrine Disorders is presented in an orderly and easy-to-follow manner, which should greatly facilitate the early recognition of endocrine diseases by medical students, house staff, primary care physicians, and endocrinologists, the four groups of clinical personnel to which this book is specificall y directed.…

Taschenbuch. Condizione: Neu. Neuware - The increased attendance required concurrent sessions for the 48 oral presentations and 190 submitted posters (for more details see Website: ct.ornl.gov/symposium). Attendees came from Australia, Austria, Belgium, Brazil, Canada, China, Denmark, Finland, Germany, Hungary, India, Japan, Korea, Mexico, The Netherlands, Russia, South Korea, Spain, Sweden, Turkey, and Ven ezuela, as well as from the United States. This international perspective was continued in a Special Topic Ses sion sponsored by the International Energy Agency (lEA) Bioenergy Pro gram on Biofuels and chaired by Jack Saddler and David Gregg from the University of British Columbia. Several of the 10 member countries in this network are approaching Demonstrations of the Biomass-to-Ethanol pro cess and have a range of more fundamental projects that look at various aspects of pretreatment, enzymatic hydrolysis, fermentation, and lignin utilization. Presenters from several of the participating countries described their country's biomass-to-ethanol projects, and differential factors such as the type of biomass available, the maturity of the wood or agricultural processing industry, and the willingness of government to bear the risk/ cost of development and demonstration. …

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Opioid research is one of the multidisciplinary research areas that involve advanced techniques ranging from molecular genetics to neuropharmacology, and from behavioral neuroscience to clinical medicine. In current opioid research, it has become increasingly important to use multiple approaches at molecular, cellular, and system levels for investigations on a specific opio- related target system. That often requires understanding and applying cro- field techniques and methods for the success of one's research projects. Through its broad spectrum of coverage, Opioid Research: Methods and Protocols provides a comprehensive collection of major laboratory methods and protocols in current opioid research, covering topics from molecular and genetic techniques to behavioral analyses of animal models, and then to clinical practice. It will serve as a convenient reference book from which those involved in opioid research will learn or perfect the necessary cross-field techniques. The detailed methods and protocols described in Opioid Research: Methods and Protocols have each been successfully applied in current opioid research. Part I provides molecular techniques for the cloning and expression of opioid receptors, and for the quantitative characterization of their signaling pathways. Part II includes primary techniques for mapping the distributions and detecting the expression levels of opioid receptors, opioid peptides, and their messages in brain tissues and in individual cells. Part III deals with methods for creating in vitro receptor models and in vivo animal models to study opioid functions. Part IV describes practical applications of opioids in clinical medicine for the treatment of pain and opioid addiction. 320 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Despite five decades of research, parallel computing remains an exotic, frontier technology on the fringes of mainstream computing. Its much-heralded triumph over sequential computing has yet to materialize. This is in spite of the fact that the processing needs of many signal processing applications continue to eclipse the capabilities of sequential computing. The culprit is largely the software development environment. Fundamental shortcomings in the development environment of many parallel computer architectures thwart the adoption of parallel computing. Foremost, parallel computing has no unifying model to accurately predict the execution time of algorithms on parallel architectures. Cost and scarce programming resources prohibit deploying multiple algorithms and partitioning strategies in an attempt to find the fastest solution. As a consequence, algorithm design is largely an intuitive art form dominated by practitioners who specialize in a particular computer architecture. This, coupled with the fact that parallel computer architectures rarely last more than a couple of years, makes for a complex and challenging design environment.To navigate this environment, algorithm designers need a road map, a detailed procedure they can use to efficiently develop high performance, portable parallel algorithms. The focus of this book is to draw such a road map. The Parallel Algorithm Synthesis Procedure can be used to design reusable building blocks of adaptable, scalable software modules from which high performance signal processing applications can be constructed. The hallmark of the procedure is a semi-systematic process for introducing parameters to control the partitioning and scheduling of computation and communication. This facilitates the tailoring of software modules to exploit different configurations of multiple processors, multiple floating-point units, and hierarchical memories. To showcase the efficacy of this procedure, the book presents threecase studies requiring various degrees of optimization for parallel execution. 128 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Biological systems are very special substrates for engineering-uniquely the products of evolution, they are easily redesigned by similar approaches. A simple algorithm of iterative cycles of diversification and selection, evolution works at all scales, from single molecules to whole ecosystems. In the little more than a decade since the first reported applications of evolutionary design to enzyme engineering, directed evolution has matured to the point where it now represents the centerpiece of industrial biocatalyst development and is being practiced by thousands of academic and industrial scientists in com- nies and universities around the world. The appeal of directed evolution is easy to understand: it is conceptually straightforward, it can be practiced without any special instrumentation and, most important, it frequently yields useful solutions, many of which are totally unanticipated. Directed evolution has r- dered protein engineering readily accessible to a broad audience of scientists and engineers who wish to tailor a myriad of protein properties, including th- mal and solvent stability, enzyme selectivity, specific activity, protease s- ceptibility, allosteric control of protein function, ligand binding, transcriptional activation, and solubility. Furthermore, the range of applications has expanded to the engineering of more complex functions such as those performed by m- tiple proteins acting in concert (in biosynthetic pathways) or as part of mac- molecular complexes and biological networks. 236 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Inflammation has been described as the basis of many pathologies of human disease. When one considers the updated signs of inflammation, they would be vasodilation, cell migration, and, in the case of chronic inflam- tion, cell proliferation, often with an underlying autoimmune basis. Gen- ally, inflammation may be divided into acute, chronic, and autoimmune, - though the editors believe that most, if not all, chronic states are often the result of an autoimmune response to an endogenous antigen. Thus, a proper understanding of the inflammatory basis may provide clues to new therap- tic targets not only in classical inflammatory diseases, but atherosclerosis, cancer, and ischemic heart disease as well. The lack of advances in classical inflammatory diseases, such as rh- matoid arthritis, may in part arise from a failure to classify the disease into different forms. That different forms exist is exemplified in patients with d- fering responses to existing antiinflammatory drugs, ranging from nonresponders to very positive responders for a particular nonsteroidal an- inflammatory drug (NSAID). Though researchers have progressively unr- eled the mechanisms, the story is far from complete. It should also be noted that the inflammatory response is part of the innate immune response, or to use John Hunter's words in 1795, 'inflammation is a salutary response.' That may be applied in particular to the defensive response to invading micro- ganisms. 392 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Opioid research is one of the multidisciplinary research areas that involve advanced techniques ranging from molecular genetics to neuropharmacology, and from behavioral neuroscience to clinical medicine. In current opioid research, it has become increasingly important to use multiple approaches at molecular, cellular, and system levels for investigations on a specific opio- related target system. That often requires understanding and applying cro- field techniques and methods for the success of one¿s research projects. Through its broad spectrum of coverage, Opioid Research: Methods and Protocols provides a comprehensive collection of major laboratory methods and protocols in current opioid research, covering topics from molecular and genetic techniques to behavioral analyses of animal models, and then to clinical practice. It will serve as a convenient reference book from which those involved in opioid research will learn or perfect the necessary cross-field techniques. The detailed methods and protocols described in Opioid Research: Methods and Protocols have each been successfully applied in current opioid research. Part I provides molecular techniques for the cloning and expression of opioid receptors, and for the quantitative characterization of their signaling pathways. Part II includes primary techniques for mapping the distributions and detecting the expression levels of opioid receptors, opioid peptides, and their messages in brain tissues and in individual cells. Part III deals with methods for creating in vitro receptor models and in vivo animal models to study opioid functions. Part IV describes practical applications of opioids in clinical medicine for the treatment of pain and opioid addiction.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 320 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Inflammation has been described as the basis of many pathologies of human disease. When one considers the updated signs of inflammation, they would be vasodilation, cell migration, and, in the case of chronic inflam- tion, cell proliferation, often with an underlying autoimmune basis. Gen- ally, inflammation may be divided into acute, chronic, and autoimmune, - though the editors believe that most, if not all, chronic states are often the result of an autoimmune response to an endogenous antigen. Thus, a proper understanding of the inflammatory basis may provide clues to new therap- tic targets not only in classical inflammatory diseases, but atherosclerosis, cancer, and ischemic heart disease as well. The lack of advances in classical inflammatory diseases, such as rh- matoid arthritis, may in part arise from a failure to classify the disease into different forms. That different forms exist is exemplified in patients with d- fering responses to existing antiinflammatory drugs, ranging from nonresponders to very positive responders for a particular nonsteroidal an- inflammatory drug (NSAID). Though researchers have progressively unr- eled the mechanisms, the story is far from complete. It should also be noted that the inflammatory response is part of the innate immune response, or to use John Hunter¿s words in 1795, ¿inflammation is a salutary response.¿ That may be applied in particular to the defensive response to invading micro- ganisms.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 392 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Biological systems are very special substrates for engineering¿uniquely the products of evolution, they are easily redesigned by similar approaches. A simple algorithm of iterative cycles of diversification and selection, evolution works at all scales, from single molecules to whole ecosystems. In the little more than a decade since the first reported applications of evolutionary design to enzyme engineering, directed evolution has matured to the point where it now represents the centerpiece of industrial biocatalyst development and is being practiced by thousands of academic and industrial scientists in com- nies and universities around the world. The appeal of directed evolution is easy to understand: it is conceptually straightforward, it can be practiced without any special instrumentation and, most important, it frequently yields useful solutions, many of which are totally unanticipated. Directed evolution has r- dered protein engineering readily accessible to a broad audience of scientists and engineers who wish to tailor a myriad of protein properties, including th- mal and solvent stability, enzyme selectivity, specific activity, protease s- ceptibility, allosteric control of protein function, ligand binding, transcriptional activation, and solubility. Furthermore, the range of applications has expanded to the engineering of more complex functions such as those performed by m- tiple proteins acting in concert (in biosynthetic pathways) or as part of mac- molecular complexes and biological networks.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 236 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Halogenated organic compounds constitute one of the largest groups of environmental chemicals. The industrial production of new halogenated organic compounds has increased throughout the last century peaking in the 1960s, and continuing in widespread use today. Organohalides are integral to a variety of industrial applications, including use as solvents, degreasing agents, biocides, pharmaceuticals, plasticizers, hydraulic and heat transfer fluids, and intermediates for chemical synthesis, to name a few. It is important to recognize the beneficial aspects of halogenated organic compounds, as well as their potentially deleterious impact on the environment and health. Recognition ofthe adverse environmental effects ofmanytypes oforganohalide compounds has led to efforts to reduce or eliminate the most problematic ones. Although organohalide compounds are typically considered to be anthropogenic industrial compounds, they have their counterpart in several thousands of natural biogenic and geogenic organohalides, representing most classes of organic chemicals. Natural sources account for a significant portion of the global organohalogen budget. This volume authored by recognized experts in the field provides a current perspective on how both natural and synthetic organohalides are formed and degraded, and how these processes are incorporated into a global halogen cycle. The focus is on microbial processes, since these play a major role both in the production and degradation, i. e. , cycling of halogenated organic compounds inthe environment. This book is organized into five parts. Part I, Introduction, provides a global perspective on the issues of organohalides and their fate in the environment. 518 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Prostate cancer is the second leading cancer in men in Western society. A major concern, and an area of intensive research, involves understanding why certain prostate cancers remain localized or indolent, whereas others become aggressive and metastasize. The differences between these cancer types have profound implications for patients and physicians. Indolent d- ease, which grows very slowly, generally does not cause any problems to the patient, whereas aggressive disease requires immediate treatment, the earlier the better. At present, there are no markers that discriminate between these two entities, thus causing a dilemma for the management of patients who have recently been diagnosed. The aim of Prostate Cancer Methods and Protocols is to explore cutting-edge molecular methods that may have the potential to reveal markers of disease for use in more accurate diagnoses of prostate c- cer and, consequently, to lead to new treatment strategies. This book provides a comprehensive collection of both in vitro and in vivo step-by-step protocols currently used by leaders in prostate cancer research, advice on approaches that can be used in the study of prostate cancer, as well as reviews covering areas less amenable to laboratory research, such as environmental factors in prostate cancer, to provide the reader with an overview of the prostate cancer research field as it currently stands. 420 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -It has become clear that tumors result from excessive cell proliferation and a corresponding reduction in cell death caused by the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emp- sis has shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and TSGs function in the same pathways, providing positive and negative growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Mu- tions in tumor suppressor genes have been identified in familial cancer syndromes, and the same genes in many cases have been found to be mutationally inactivated in sporadically occurring cancers. In their normal state, TSGs control cancer development and progression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pa- ways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access not only the powerful tools now available to discover these genes, but also their links to cell biology and growth control. 680 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Prostate cancer is the second leading cancer in men in Western society. A major concern, and an area of intensive research, involves understanding why certain prostate cancers remain localized or indolent, whereas others become aggressive and metastasize. The differences between these cancer types have profound implications for patients and physicians. Indolent d- ease, which grows very slowly, generally does not cause any problems to the patient, whereas aggressive disease requires immediate treatment, the earlier the better. At present, there are no markers that discriminate between these two entities, thus causing a dilemma for the management of patients who have recently been diagnosed. The aim of Prostate Cancer Methods and Protocols is to explore cutting-edge molecular methods that may have the potential to reveal markers of disease for use in more accurate diagnoses of prostate c- cer and, consequently, to lead to new treatment strategies. This book provides a comprehensive collection of both in vitro and in vivo step-by-step protocols currently used by leaders in prostate cancer research, advice on approaches that can be used in the study of prostate cancer, as well as reviews covering areas less amenable to laboratory research, such as environmental factors in prostate cancer, to provide the reader with an overview of the prostate cancer research field as it currently stands.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 420 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -It has become clear that tumors result from excessive cell proliferation and a corresponding reduction in cell death caused by the successive accumulation of mutations in key regulatory target genes over time. During the 1980s, a number of oncogenes were characterized, whereas from the 1990s to the present, the emp- sis has shifted to tumor suppressor genes (TSGs). It has become clear that oncogenes and TSGs function in the same pathways, providing positive and negative growth regulatory activities. The signaling pathways controlled by these genes involve virtually every process in cell biology, including nuclear events, cell cycle, cell death, cytoskeletal, cell membrane, angiogenesis, and cell adhesion effects. Mu- tions in tumor suppressor genes have been identified in familial cancer syndromes, and the same genes in many cases have been found to be mutationally inactivated in sporadically occurring cancers. In their normal state, TSGs control cancer development and progression, as well as contribute to the sensitivity of cancers to a variety of therapeutics. Understanding the classes of TSGs, the biochemical pa- ways they function in, and how they are regulated provides an essential lesson in cancer biology. We cannot hope to advance our current knowledge and to develop new and more effective therapies without understanding the relevant pathways and how they influence the present approaches to therapy. Moreover, it is important to be able to access not only the powerful tools now available to discover these genes, but also their links to cell biology and growth control.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 680 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Endocrine Replacement Therapy in Clinical Practice, an update of Hormone Repla- ment Therapy published by Humana Press in 1999, aims to assist the endocrinologist, gynecologist, pediatrician, urologist, general surgeon, neurologist, neurosurgeon, p- chiatrist, generalist, and trainee in management of their patients with hormonal defici- cies or altered hormonal synthesis or responses. Many new authors have added several new chapters, and all of the previous chapters have been updated. Endocrine testing used to diagnose endocrine disorders and monitor hormone replacement therapy is reviewed. However, detailed discussion of physiology and pathophysiology is not an aim of this book, and these topics are covered in other volumes on endocrinology. Although no one is considered an expert in all areas of endocrine replacement therapy, each of the authors here have extensive knowledge and experience in the management of patients with s- cific endocrine disorders requiring hormone replacement treatment. Although some differences of opinion exist among experts in replacement therapy, each writer has attempted to give a balanced, unbiased recommendation. When com- rable regimens exist, the authors have made this apparent to the reader who can then choose the best treatment for the individual patient. Cost, therapeutic effectiveness, and route of administration are all important considerations in making the final selection of replacement therapy.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 564 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -The Scientification of Gastroenterology During the 20th Century \* Science contributes to medicine in three ways: It provides a body of relatively secure knowl edge. Some of that knowledge has been applied to develop technologies which have had a major impact upon the practice and effectiveness of medicine. Last, science offers to medicine a way of thinking. - 1. McCormick [(1993) The Contribution of Science to Medicine. Perspect. Bioi. Med. 16,315.] Awareness of the digestive system began with the dawn of civilization, when man, observing the feeding habits of animals in the surrounding environment, experimented with foods, edible and inedible. Identity came with discoveries of the digestive organs during the 16th and 17th centuries. Function was revealed by physiologic studies of digestion, absorp tion and secretion, metabolism, and motility during the 18th and 19th centuries. Diagnostic access improved with the technological advances of the 20th century. Understanding of gas trointestinal (GI) disease followed the growth of the basic sciences and gastroenterology's involvement in scientific research during the latter half of the 20th century. Early in the 20th century, gastroenterology was yet an undefined activity without clinical or scientific guidelines. Diagnostic approach to the digestive tract was minimal. Valid con cepts of disease were lacking. Visceroptosis, sitophobia, and 'colonic autointoxication' were common 'diagnoses.' Therapeutic resources were scarce.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 588 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -During the past twenty years, multitudes of exciting discoveries in the field of anaerobic bacteria have been made. Biochemistry and Physiology of Anaerobic Bacteria explores the full range of these microorganisms. Many anaerobes have been found to have the uniquely fascinating quality of being able to survive, indeed even thrive, in extreme environments. Anaerobic bacteria often do not require oxygen, can survive extremes in temperature, and can withstand the presence of toxins and heavy metals. In addition, these organisms have very different metabolic processes than 'conventional' microorganisms. The wide diversity of metabolism in anaerobes is only part of the story. They have distinct energies, cytochromes, electron transport proteins, hydrogenases and dehydrogenases. Their molecular biology, physiology, and ability to use many types of electron receptors (CO2, sulfur, nitrogen and metal oxides) are also extraordinary. With practical applications ranging from wastewater treatment to food storage issues, clinical diagnosis and treatment of a wide range of medical conditions to decontamination of heavy metal exposures Biochemistry and Physiology of Anaerobic Bacteria will prove indispensable to researchers and students alike.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 292 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Timothy R. Koch, MD, has assembled a panel of innovative basic researchers, esteemed clinical investigators, and well-known clinicians to bridge the gap between basic and clinical research and the day-to-day care of patients with colonic disorders. After a review of the basic science and mechanisms of colonic diseases, the authors fully discuss potential symptoms, pathological and radiological findings, the differential diagnosis, and presently recommended evaluation and therapy, including the use of probiotics. New areas of potential treatment not presently available for patients with chronic symptoms are also examined, along with the advanced treatment techniques currently in use at the Cleveland Clinic (for ulcerative colitis), The University of Chicago (for Crohn's disease), the Mayo Clinic (for irritable bowel syndrome), and the MD Anderson Cancer Center (for colorectal cancer). 588 pp. Englisch.…

Taschenbuch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Surgical Pathology Dissection, Second Edition fills the need for a comprehensive, fully illustrated guide to the preparation, dissection, and handling of surgical pathology specimens. The authors share their wealth of talent and experiences by providing general principles that can be employed to resolve even the most complex problems in dissection and tissue sampling. The descriptive text is augmented by 62 exclusive, detailed illustrations printed as full-page plates depicting proper specimen handling techniques that add a unique vitality and multidimensional effect. Each chapter features a section on Important Issues to Address in Your Surgical Pathology Report and references selected for their pertinent coverage of specimen handling for each organ system.Updated and revised, this second edition includes four new chapters and expanded discussions on: Preparation of Tissues for Molecular Analysis; Craniofacial Bones; Heart; Transplantation Specimens; The Sentinel Lymph Node. Revisions have been made to conform to suggested guidelines proposed by the College of American Pathologists.From reviews of the first edition:'Hruban, Westra and Isacson, working with a superb medical illustrator did an admirable job in taking the Johns Hopkins' gross room manual and translating it into a practical, concise, and easily accessible guide to contemporary practice in the surgical pathology laboratory.'(Modern Pathology)Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 280 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Endocrine Replacement Therapy in Clinical Practice, an update of Hormone Repla- ment Therapy published by Humana Press in 1999, aims to assist the endocrinologist, gynecologist, pediatrician, urologist, general surgeon, neurologist, neurosurgeon, p- chiatrist, generalist, and trainee in management of their patients with hormonal defici- cies or altered hormonal synthesis or responses. Many new authors have added several new chapters, and all of the previous chapters have been updated. Endocrine testing used to diagnose endocrine disorders and monitor hormone replacement therapy is reviewed. However, detailed discussion of physiology and pathophysiology is not an aim of this book, and these topics are covered in other volumes on endocrinology. Although no one is considered an expert in all areas of endocrine replacement therapy, each of the authors here have extensive knowledge and experience in the management of patients with s- cific endocrine disorders requiring hormone replacement treatment. Although some differences of opinion exist among experts in replacement therapy, each writer has attempted to give a balanced, unbiased recommendation. When com- rable regimens exist, the authors have made this apparent to the reader who can then choose the best treatment for the individual patient. Cost, therapeutic effectiveness, and route of administration are all important considerations in making the final selection of replacement therapy. 564 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -A comprehensive survey on the use of bedside skills and perimetric devices to the test visual fields, and how to interpret the results. To develop the clinician's interpretative skills, the authors include a chapter on visual anatomy and an atlas of 100 real-life cases arranged in anatomic order from retina to striate cortex. By placing a brief clinical vignette with a visual field on one side of the page and a description of the field and its causal lesion on the opposite side, the reader will be able to learn interpretation in a simulated clinical setting. An additional quiz section of twenty randomly arranged visual fields provides readers with an opportunity to test their newly acquired skills. Although the visual field provides clinicians with important diagnostic information for many neurologic and ophthalmologic conditions, its evaluation is often perceived as difficult or mysterious. In Field of Vision: A Manual and Atlas of Perimetry, neuro-ophthalmologist Jason J.S. Barton, MD, PhD, and neurologist Michael Benatar, MBChB, DPhil, provide a comprehensive overview of the use of both perimetric devices and bedside testing, and how to interpret the results. The authors focus on the clinically relevant points, providing enough technical detail and anatomic knowledge for the physician to competently examine patients with a perimeter. To develop the clinician's skill in interpretation, the authors include an atlas of 100 real-life cases arranged in anatomic order from retina to striate cortex. Each case contains a brief clinical vignette, a visual field, and a description of the field and its causal lesion, most with photographs of the pathology. The accompanying discussion addresses the nuances of the field and considers some of the clinical issues relevant to each case. An additional quiz section of 20 randomly arranged visual fields provides readers with an opportunity to test newly acquired skills in detecting the abnormalities, describing them, localizing them, and making a reasonable guess at their pathology. Simply written and clinically focused, Field of Vision: A Manual and Atlas of Perimetry brings together in an accessible format the specialist knowledge and skills needed by today's clinicians to successfully measure and interpret the visual fields of patients. 352 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -A comprehensive survey on the use of bedside skills and perimetric devices to the test visual fields, and how to interpret the results. To develop the clinician's interpretative skills, the authors include a chapter on visual anatomy and an atlas of 100 real-life cases arranged in anatomic order from retina to striate cortex. By placing a brief clinical vignette with a visual field on one side of the page and a description of the field and its causal lesion on the opposite side, the reader will be able to learn interpretation in a simulated clinical setting. An additional quiz section of twenty randomly arranged visual fields provides readers with an opportunity to test their newly acquired skills.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 352 pp. Englisch.…