Humana aug 2004 (11 risultati)

Buch. Condizione: Neu. Neuware - From birth to death, the insulin-like growth factors (IGF) -a system of proteins, binding proteins, and cell receptors that are widely expressed in all tissues-plays critical roles in metabolism, normal growth and development, and numerous acute and chronic diseases. The IGF system is fundamentally related to growth hormone and insulin, but also nutritional state. In IGF and Nutrition in Health and Disease, leading researchers and physicians from diverse disciplines comprehensively review for the first time how specific nutrients or adverse nutritional states impact gene expression, circulating concentrations, and bioactivity of the IGF proteins. The authors describe the fundamentals of the IGF system, explain its basic mechanisms of action, and examine the interactions between IGF and nutritional status from the molecular to the population levels. Their discussion of the essential interrelationships between IGF and nutrition, including specific nutrients, in physical development across the life span illuminates the balance between normal growth and development and abnormal cellular growth resulting in tumor formation. They also fully examine the clinical aspects of nutrition and IGF, from pre- and postnatal development through old age, in the maintenance of normal metabolism, bone and muscle health, and their role in pathological states. Special attention is given to critical illness, diabetes, gastrointestinal diseases, kidney failure, endocrine dysfunctions, cardiovascular disease, neurological disorders, and cancer, as well as to their potential for IGF therapy. Comprehensive and authoritative, IGF and Nutrition in Health and Disease is a benchmark review of nutrition and the IGF system in human health and disease, providing a clear understanding of the critical importance of the IGF system and nutritional state to human growth, metabolism, disease development, and therapy. …

Buch. Condizione: Neu. Neuware - When I was asked to edit the second edition of Protein NMR Techniques, my first thought was that the time was ripe for a new edition. The past several years have seen a surge in the development of novel methods that are truly revolutionizing our ability to characterize biological macromolecules in terms of speed, accuracy, and size limitations. I was particularly excited at the prospect of making these techniques accessible to all NMR labs and for the opportunity to ask the experts to divulge their hints and tips and to write, practically, about the methods. I commissioned 19 chapters with wide scope for Protein NMR Techniques, and the volume has been organized with numerous themes in mind. Chapters 1 and 2 deal with recombinant protein expression using two organisms, E. coli and P. pastoris, that can produce high yields of isotopically labeled protein at a reasonable cost. Staying with the idea of isotopic labeling, Chapter 3 describes methods for perdeuteration and site-specific protonation and is the first of several chapters in the book that is relevant to studies of higher molecular weight systems. A different, but equally powerful, method that uses molecular biology to 'edit' the spectrum of a large molecule using segmental labeling is presented in Chapter 4. Having successfully produced a high molecular weight target for study, the next logical step is data acquisition. Hence, the final chapter on this theme, Chapter 5, describes TROSY methods for stru- ural studies.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -As a group, normal middle-aged men tend to fly well below the radar screen of public scrutiny. They are neither deviants nor superheroes. Rarely the subject of movies or newspaper headlines, regular guys aren't fabulously wealthy, nor are their ambitions circumscribed. They contribute to society, raise their children, and respect other people. Nevertheless, these regular guys have experienced their share of adversity and emotional challenges-such a divorce, death, illness, and loss of jobs-but reflect a continuing core of emotional stability.Regular Guys follows 67 well-adjusted mostly white males, who were initially chosen during the 1960s, to test theories of normal adolescent functioning. They were reinterviewed at age 48 to examine male functioning at middle age. This unique, 34-year study contrasts the critical period of adolescent development, which has been culturally characterized by stress and turmoil, with the relative stability of middle age. It addresses such issues as:- Attitudes and behaviors concerning work, sex, religion, and self.- Relationships with parents, siblings, spouses, and children.- Coping and resilience in response to trauma.- Negative health behaviors (particularly overeating and problem drinking as adults).- Memories of their teenage years.The authors' findings are likely to be of considerable interest and use to clinicians and academics alike. In addition, the results provide a baseline as to what, by contrast, reflects psychopathology. Regular Guys provides a much-needed portrait of individuals rarely studied across several decades of time. 172 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -Goals and Emphasis of the Book Mathematicians have begun to find productive ways to incorporate computing power into the mathematics curriculum. There is no attempt here to use computing to avoid doing differential equations and linear algebra. The goal is to make some first ex plorations in the subject accessible to students who have had one year of calculus. Some of the sciences are now using the symbol-manipulative power of Mathemat ica to make more of their subject accessible. This book is one way of doing so for differential equations and linear algebra. I believe that if a student's first exposure to a subject is pleasant and exciting, then that student will seek out ways to continue the study of the subject. The theory of differential equations and of linear algebra permeates the discussion. Every topic is supported by a statement of the theory. But the primary thrust here is obtaining solutions and information about solutions, rather than proving theorems. There are other courses where proving theorems is central. The goals of this text are to establish a solid understanding of the notion of solution, and an appreciation for the confidence that the theory gives during a search for solutions. Later the student can have the same confidence while personally developing the theory. 452 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Behaviour at work can no longer be stereotyped as global or local ¿ modern or traditional ¿ with very little in-between. Instead work behaviour is a complex interplay between Global and Local values. It takes place in a Glocality. Thus individual achievement co-exists with group aspirations, pay diversity takes place in a social context, teamwork reflects cultural narrative, and labour mobility is bound by community bias. Globalization and Culture at Work: Exploring their Combined Glocality breaks new ground by exploring such glocalities, and the implications they create for managing human potential better. The volume is essential reading for researchers, managers, culturalists and consultants of work behaviour alike.Springer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 206 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -An indispensable collection of updated classical and emerging techniques that promise to add critical knowledge to our understanding of cartilage metabolism in health and disease. Volume 1: Cellular and Molecular Tools describes proven molecular and cellular techniques for the in vitro study of normal and osteoarthritic cartilage through biochemical, biomolecular, immunological, and physical approaches, with emphasis on the genetic manipulation of cells. Volume 2: Structure and In Vivo Analysis, offers cutting-edge procedures for the study-at the tissue level-of turnover, structure, and functioning of normal and diseased articular cartilage by invasive and noninvasive means. Comprehensive and up-to-date, the two volumes of Cartilage and Osteoarthritis provide researchers and bench scientists with readily reproducible protocols for new experiments to understand-from the cellular to the animal level-the pathophysiology of cartilage and to discover molecular targets for pharmacological intervention. 360 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -An indispensable collection of updated classical and emerging techniques that promise to add critical knowledge to our understanding of cartilage metabolism in health and disease. Volume 1: Cellular and Molecular Tools describes proven molecular and cellular techniques for the in vitro study of normal and osteoarthritic cartilage through biochemical, biomolecular, immunological, and physical approaches, with emphasis on the genetic manipulation of cells. Volume 2: Structure and In Vivo Analysis, offers cutting-edge procedures for the study-at the tissue level-of turnover, structure, and functioning of normal and diseased articular cartilage by invasive and noninvasive means. Comprehensive and up-to-date, the two volumes of Cartilage and Osteoarthritis provide researchers and bench scientists with readily reproducible protocols for new experiments to understand-from the cellular to the animal level-the pathophysiology of cartilage and to discover molecular targets for pharmacological intervention.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 360 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - it takes 3-4 days longer - Neuware -12 The average human body has on the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in Western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well-established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 1. 532 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -12 The average human body has on the order of 10 circulating platelets. They are crucial for hemostasis, and yet excessive platelet activation is a major cause of m- bidity and mortality in Western societies. It is therefore not surprising that platelets have become one of the most extensively investigated biological cell types. We are, however, far from understanding precisely how platelets become activated under physiological and pathophysiological conditions. In addition, there are large gaps in our knowledge of platelet production from their giant precursor cell, the megakar- cyte. Understanding megakaryocyte biology will be crucial for the development of platelet gene targeting. The aim of Platelets and Megakaryocytes is therefore to bring together established and recently developed techniques to provide a comprehensive guide to the study of both the platelet and the megakaryocyte. It consists of five s- tions split between two volumes. The more functional assays appear in Volume 1, whereas Volume 2 includes signaling techniques, postgenomic methods, and a n- ber of key perspectives chapters. Part I of Volume 1, Platelets and Megakaryocytes: Functional Assays, describes many well-established approaches to the study of platelet function, including aggregometry, secretion, arachidonic acid metabolism, procoagulant responses, pla- let adhesion under static or flow conditions, flow cytometry, and production of microparticles. Although one would ideally wish to perform experiments with human platelets, studies within the circulation using intravital microscopy require the use of animal models, which are described in Chapter 16, vol. 1.Humana Press in Springer Science + Business Media, Heidelberger Platz 3, 14197 Berlin 532 pp. Englisch.…

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Biomedical EPR ¿ Part B focuses on applications of EPR techniques and instrumentation, with applications to dynamics. The book celebrates the 70th birthday of Prof. James S. Hyde, Medical College of Wisconsin, and his contributions to this field. Chapters are written to provide introductory material for new-comers to the field that lead into up-to-date reviews that provide perspective on the wide range of questions that can be addressed by EPR.Key Features:EPR Techniques including Saturation Recovery, ENDOR, ELDOR, and Saturation TransferInstrumentation Innovations including Loop Gap Resonators, Rapid Mixing, and Time Locked Sub-SamplingMotion in Biological MembranesApplications to Structure Determination in ProteinsDiscussion of Trends in EPR Technology and Prognosis for the FutureSpringer-Verlag KG, Sachsenplatz 4-6, 1201 Wien 500 pp. Englisch. …

Buch. Condizione: Neu. This item is printed on demand - Print on Demand Titel. Neuware -Chlamydia pneumoniae is a bacteria that is most commonly known for causing colds and pneumonia. However, researchers have recently found a link between C. pneumoniae and atherosclerosis, a clogging of the arteries that causes heart attack and stroke. In addition, ongoing research is showing that certain strains may play a role in asthma, multiple sclerosis, Alzheimer's disease, and arthritis.This volume, part of the Infectious Agents and Pathogenesis series, is a complete portrait of C. pneumoniae and what is currently known about it.Springer-Verlag GmbH, Tiergartenstr. 17, 69121 Heidelberg 312 pp. Englisch.…